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Articles 1 - 22 of 22
Full-Text Articles in Medicine and Health Sciences
Effects Of Swimming Frequency On Body Weight And Serum Lipid Profile In Small-Breed Dogs During A Four-Month Period, Korakot Nganvongpanit, Napat Ruamrungsri, Boonyapawn Tepsoontorn, Terdsak Yano, Puntita Siengdee, Siriphun Kongsawasdi
Effects Of Swimming Frequency On Body Weight And Serum Lipid Profile In Small-Breed Dogs During A Four-Month Period, Korakot Nganvongpanit, Napat Ruamrungsri, Boonyapawn Tepsoontorn, Terdsak Yano, Puntita Siengdee, Siriphun Kongsawasdi
The Thai Journal of Veterinary Medicine
Lack of activities for dogs, that is, decreased body motion and lack of opportunities to exercise, can cause dogs to become overweight. Swimming is one of the best physical exercises for a dog that has been approved by a veterinary doctor, and it provides a form of supported exercise. Almost all the muscles are required for the movement that involves improving strength, working the cardiovascular and respiratory system, and increasing the metabolic rate withoutimpact on joints. One interesting aspect of swimming is its ability for weight and serum lipid control. The effect of frequency-controlled swimming activity on a dog’s weight …
Immunophenotyping Of Cutaneous Extramedullary Plasmacytoma In Two Dogs, Chutchai Piewbang, Sirintra Sirivisoot, Sitthichok Lacharoje, Anudep Rungsipipat, Somporn Techangamsuwan
Immunophenotyping Of Cutaneous Extramedullary Plasmacytoma In Two Dogs, Chutchai Piewbang, Sirintra Sirivisoot, Sitthichok Lacharoje, Anudep Rungsipipat, Somporn Techangamsuwan
The Thai Journal of Veterinary Medicine
Skin biopsied tissues from two dogs, initially diagnosed as hemophagocytic histiocytic sarcoma (HHS) by histopathology, were immunostained with a series of antibodies against lambda light chains, kappa light chains, multiple myeloma oncoprotein 1 (MUM-1), CD-3, paired box 5 (PAX-5), E-cadherin and lysozyme. Heteroduplex polymerase chain reaction for antigen receptor rearrangements (hPARR) was additionally performed on formalin-fixed paraffin-embedded (FFPE) tissues to rule out lymphomas from histiocytomas. Results showed that both cases were immunopositive for lambda light chains, MUM-1, PAK-5 and lysozyme, indicating a diagnosis of extramedullary plasmacytoma (EMP). Moreover, negative PCR result provided additional evidence confirming the diagnosis. Even though hPARR …
Evaluating The Physical Welfare Of Dogs In Commercial Breeding Facilities In The United States, Moriah J. Hurt
Evaluating The Physical Welfare Of Dogs In Commercial Breeding Facilities In The United States, Moriah J. Hurt
Open Access Theses
Despite high levels of public concern, the state of commercial breeding (CB) dog welfare is largely unknown. Therefore, this study aimed to characterize the physical welfare of dogs in CB facilities and their environment in Indiana. This study specifically aimed 1) to characterize dog foot health in CB facilities as a function of the length of time dogs were housed on a given flooring substrate, 2) to characterize visual dog body cleanliness and visual kennel cleanliness as a function of the flooring substrate, 3) to determine the efficacy of kennel cleaning procedures and 4) to characterize the dog dental and …
Diagnosis Of Pharyngeal Sialocele In A Dog By Ct Scan : A Case Report, Sekkarin Ploypetch, Nan Choisunirachon, Chanin Kalpravidh
Diagnosis Of Pharyngeal Sialocele In A Dog By Ct Scan : A Case Report, Sekkarin Ploypetch, Nan Choisunirachon, Chanin Kalpravidh
The Thai Journal of Veterinary Medicine
A 7-year-old, 10 kg male poodle dog was presented at the Small Animal Teaching Hospital, with the clinical signs of chronic coughing, bad deglutition and severe respiratory distress. On oral examination, a large mass arisen from the throat was found. Because the skull-cervical radiographs revealed only a large soft tissue pharyngeal mass which were difficult to indicate the mass types and the tissue invasiveness, the computed tomography (CT) was subsequently applied. The CT result showed that the mass was an encapsulated hypoattenuation mass (2.5 x 4.3 x 2.4 cm) at the right pharyngeal area without any adjacent soft tissue invasions. …
Activated Partial Thromboplastin Time (Aptt) In Dogs Tested By In-House Crude Cephalin From Canine Brain, Sarawut Yama, Am Chaimongkhol, Somsak Channoi, Sakhorn Pornprasert, Wanna Suriyasathaporn
Activated Partial Thromboplastin Time (Aptt) In Dogs Tested By In-House Crude Cephalin From Canine Brain, Sarawut Yama, Am Chaimongkhol, Somsak Channoi, Sakhorn Pornprasert, Wanna Suriyasathaporn
The Thai Journal of Veterinary Medicine
This research aimed to identify the reference value of activated partial thromboplastin time (APTT) in normal dogs using crude cephalin prepared in-house from canine brain, and to examine its efficacy in detecting disorders of coagulation factors. A total of 105 blood samples were collected from normal dogs between January-May 2010. The APTT value was found to be 10.43-19.08 seconds and significantly correlated with the APTT value of a test using a commercial reagent (Pearson’s correlation, r = 0.9923, p < 0.001). On testing the reagent’s efficacy in detecting disorders of coagulation factors by using cryopoor plasma, it was discovered that the APTT value ranged from 24.50 to 33.44 seconds, and the mean value of the APTT by means of cryopoor plasma was significantly greater than that of normal dogs (p < 0.001). The aforementioned APTT value significantly correlated with that obtained by means of a commercial reagent (Pearson’s correlation, r = 0.9984, p < 0.001). From this research, it can be confirmed that in-house crude cephalin can be substituted for commercial crude cephalin. Besides, the obtained reference range can further be applied in veterinary hematology laboratory.
Association Between Cephalexin Administration And Emergence Of Methicillin-Resistant Coagulase-Positive Staphylococci (Mrcops) In Dogs, Punpichaya Fungwithaya, Pattrarat Chanchaithong, Nathita Phumthanakorn, Passana Muaungkong, Pitikarn Bumpenpol, Mutchamon Kaewparuehaschai, Chanwit Tribudharat, Nuvee Prapasarakul
Association Between Cephalexin Administration And Emergence Of Methicillin-Resistant Coagulase-Positive Staphylococci (Mrcops) In Dogs, Punpichaya Fungwithaya, Pattrarat Chanchaithong, Nathita Phumthanakorn, Passana Muaungkong, Pitikarn Bumpenpol, Mutchamon Kaewparuehaschai, Chanwit Tribudharat, Nuvee Prapasarakul
The Thai Journal of Veterinary Medicine
The potential transmission of methicillin-resistant coagulase-positive staphylococci (MRCoPS) between dogs and human has been noted as of potential public health concern. The current study aimed to determine the emergence of methicillin-resistant coagulase-positive staphylococci (MRCoPS) in dogs after oral administration of cephalexin. Skin swabs from 38 dogs without a history of antibiotic exposure were collected before drug administration (pre-treatment dogs) and during drug administration within one month (treatment dogs). A total of 196 CoPS were isolated from the nose, perineum and skin lesions. Fewer MRCoPS were isolated from the pre-treatment dogs (7.89%) than from the treatment dogs (p<0.001). Methicillin-resistant Staphylococcus (S.) schleiferi subsp. coagulans (MRSSc) were only recovered from the treatment dogs, whereas methicillin-resistant S. pseudintermedius (MRSP) were found in both groups. Overall, a high incidence of MRSP was found since the first week after administration. The nose and perineum were confirmed as the most common site of carriage of MRCoPS rather than the skin lesions. In conclusion, the oral cephalexin administration was associated with the emergence of MRCoPS on dog skin, a potential source of contamination to humans.
Evaluation Of Pain And Prostate Volume Of Dogs Treated With Intra-Prostatic Injection Of Botulinum Toxin Type A, Pintira Thiangthientham, Kaywalee Chatdarong, Suppawiwat Ponglowhapan
Evaluation Of Pain And Prostate Volume Of Dogs Treated With Intra-Prostatic Injection Of Botulinum Toxin Type A, Pintira Thiangthientham, Kaywalee Chatdarong, Suppawiwat Ponglowhapan
The Thai Journal of Veterinary Medicine
Recently, alternative medical treatment of benign prostatic hyperplasia (BPH) using intra-prostatic injection of botulinum toxin type A (BT-A) has been reported in men and mice. However, in terms of animal welfare, it remains questionable when applied to clinical use. This study aimed at evaluating the effects of intra-prostatic injection of BT-A (Botox, Allergan, USA) in dogs. Six healthy intact males with no clinical signs of BPH received 100 units of BT-A by ultrasound-guided transabdominal intra-prostatic injection (50 units of each prostatic lobe). Pain scoring, evaluation of white blood cell counts, cortisol concentrations, and observation of urination behaviour were recorded before …
Raav2/5 Gene-Targeting To Rods: Dose-Dependent Efficiency And Complications Associated With Different Promoters, William Beltran, Sanford L. Boye, Shannon E. Boye, Vince A. Chiodo, Alfred S. Lewin, William W. Hauswirth, Gustavo D. Aguirre
Raav2/5 Gene-Targeting To Rods: Dose-Dependent Efficiency And Complications Associated With Different Promoters, William Beltran, Sanford L. Boye, Shannon E. Boye, Vince A. Chiodo, Alfred S. Lewin, William W. Hauswirth, Gustavo D. Aguirre
Gustavo D. Aguirre, VMD, PhD
A prerequisite for using corrective gene therapy to treat humans with inherited retinal degenerative diseases that primarily affect rods is to develop viral vectors that target specifically this population of photoreceptors. The delivery of a viral vector with photoreceptor tropism coupled with a rod-specific promoter is likely to be the safest and most efficient approach to target expression of the therapeutic gene to rods. Three promoters that included a fragment of the proximal mouse opsin promoter (mOP), the human G-protein-coupled receptor protein kinase 1 promoter (hGRK1), or the cytomegalovirus immediate early enhancer combined with the chicken β actin proximal promoter …
Photoreceptor Dysplasia: An Inherited Progressive Retinal Atrophy Of Miniature Schnauzer Dogs, Charles J. Parshall, Milton Wyman, Susan Nitroy, Gregory M. Acland, Gustavo D. Aguirre
Photoreceptor Dysplasia: An Inherited Progressive Retinal Atrophy Of Miniature Schnauzer Dogs, Charles J. Parshall, Milton Wyman, Susan Nitroy, Gregory M. Acland, Gustavo D. Aguirre
Gustavo D. Aguirre, VMD, PhD
A progressive retinal atrophy (PRA) affecting Miniature Schnauzer dogs is reported. Of the 287 individuals (148 female, 139 male) comprising the study population, 66 (23 percent) were affected (33 female, 33 male) and 221 animals (115 female, 106 male) were phenotypically normal. There was no sex predilection for the disease. Results of histologic and electroretinographic studies indicate that the disease is a new and different type of PRA, characterized by unique morphologic and functional deficits during rod and cone development. Accordingly, the disease has been termed photoreceptor dysplasia. Clinically, and particularly ophthalmoscopically, diagnosis is only practicable in very late stages …
Posterior Lenticonus In The Dog, Gustavo D. Aguirre, Stephen I. Bistner
Posterior Lenticonus In The Dog, Gustavo D. Aguirre, Stephen I. Bistner
Gustavo D. Aguirre, VMD, PhD
Posterior lenticonus is a congenital defect of the posterior lenticular surface. The posterior cortical and capsular regions of the lens have a circumscribed conelike or globular protrusion of variable size. Opacities may be present in the region of the conus. The defect has been reported in man, rabbits, calves and mice. This report documents 2 cases in unrelated dogs. The possible mechanism for the formation of this defect is discussed.
Posterior Segment Approach For Subretinal Transplantation Or Injection In The Canine Model, Maria E. Verdugo, Julie Alling, Eliot Lazar, Manuel Del Cerro, Jharna Ray, Gustavo D. Aguirre
Posterior Segment Approach For Subretinal Transplantation Or Injection In The Canine Model, Maria E. Verdugo, Julie Alling, Eliot Lazar, Manuel Del Cerro, Jharna Ray, Gustavo D. Aguirre
Gustavo D. Aguirre, VMD, PhD
A posterior segment approach for cell transplantation or injection into the subretinal space of the dog has been developed. Controlled penetration to the subretinal space was achieved using a 29-gauge injection cannula, either blunted or with a 30° sharpened bevel, and partially ensheathed with moveable plastic tubing. Depending on the injection volume used, the retina detached, and the fluid was reabsorbed within 1–3 weeks, although for smaller volumes the retina reattached within a matter of days. The optimal injection volume used was between 100 and 150 μl, or two injections of 55 μl each. By ophthalmoscopy following the surgery, it …
Assessment Of Canine Best1 Variations Identifies New Mutations And Establishes An Independent Bestrophinopathy Model (Cmr3), Barbara Zangerl, Kaisa Wickström, Julianna Slavik, Sarah J. Lindauer, Saija Ahonen, Claude Schelling, Hannes Lohi, Karina E. Guziewicz, Gustavo D. Aguirre
Assessment Of Canine Best1 Variations Identifies New Mutations And Establishes An Independent Bestrophinopathy Model (Cmr3), Barbara Zangerl, Kaisa Wickström, Julianna Slavik, Sarah J. Lindauer, Saija Ahonen, Claude Schelling, Hannes Lohi, Karina E. Guziewicz, Gustavo D. Aguirre
Gustavo D. Aguirre, VMD, PhD
Purpose: Mutations in bestrophin 1 (BEST1) are associated with a group of retinal disorders known as bestrophinopathies in man and canine multifocal retinopathies (cmr) in the dog. To date, the dog is the only large animal model suitable for the complex characterization and in-depth studies of Best-related disorders. In the first report of cmr, the disease was described in a group of mastiff-related breeds (cmr1) and the Coton de Tulear (cmr2). Additional breeds, e.g., the Lapponian herder (LH) and others, subsequently were recognized with similar phenotypes, but linked loci are unknown. …
A Kutya Mint Modell Az Örökletes Retinadegenerációk Kutatásában / The Dog As A Model In Research Into Inherited Retinal Degenerations, Ágnes I. Berta, Ágoston Szél, Gustavo D. Aguirre
A Kutya Mint Modell Az Örökletes Retinadegenerációk Kutatásában / The Dog As A Model In Research Into Inherited Retinal Degenerations, Ágnes I. Berta, Ágoston Szél, Gustavo D. Aguirre
Gustavo D. Aguirre, VMD, PhD
Összefoglalás: A kutya mint modellállat csak az elmúlt 15 évben került az érdeklődés középpontjába. A kutya retinája különösen érdekes, mivel számos örökletes retinadegeneráció szoros homológiát mutat az ember hasonló betegségeivel. Röviden összefoglaljuk a kutya retinájának sajátosságait és azokat az alapkutatásban használt módszereket, melyek segítségével a retina degenerációja leírható kutyában. A kutya örökletes retinadegenerációi közül a szemészek számára a legérdekesebb csoport a progresszív retinalis atrophia (PRA), mivel genetikai, patológiai és klinikai szempontból is nagyon hasonló a retinitis pigmentosa különböző típusaihoz. A PRA csoport tagjai élő modellrendszerek, melyek alkalmazhatók az örökletes retinadegenerációk alap- és klinikai kutatásában egyaránt. Ezekben a súlyos és mindenekelőtt …
Application Of A New Subretinal Injection Device In The Dog, András M. Komáromy, Signe E. Varner, Eugene De Juan, Gregory M. Acland, Gustavo D. Aguirre
Application Of A New Subretinal Injection Device In The Dog, András M. Komáromy, Signe E. Varner, Eugene De Juan, Gregory M. Acland, Gustavo D. Aguirre
Gustavo D. Aguirre, VMD, PhD
The use of a new subretinal injection device (RetinaJect™ Subretinal Cannula, SurModics, Inc., Eden Prairie, MN) to access the subretinal space in the canine model was evaluated. Subretinal injections were performed in 33 mongrel dogs between 2 and 52 months of age (median = 9 months). In 5 normal dogs the injection of 150 μl saline or India ink occurred by using a conventional subretinal injection device (CSID) with a 30-gauge anterior chamber irrigating cannula. The sclera had to be surgically exposed and penetrated before the subretinal injection with the CSID could occur. After removing the CSID, the conjunctiva over …
Intravitreal Injection Of Ciliary Neurotrophic Factor (Cntf) Causes Peripheral Remodeling And Does Not Prevent Photoreceptor Loss In Canine Rpgr Mutant Retina, William Beltran, Rong Wen, Gregory M. Acland, Gustavo D. Aguirre
Intravitreal Injection Of Ciliary Neurotrophic Factor (Cntf) Causes Peripheral Remodeling And Does Not Prevent Photoreceptor Loss In Canine Rpgr Mutant Retina, William Beltran, Rong Wen, Gregory M. Acland, Gustavo D. Aguirre
Gustavo D. Aguirre, VMD, PhD
Ciliary neurotrophic factor (CNTF) rescues photoreceptors in several animal models of retinal degeneration and is currently being evaluated as a potential treatment for retinitis pigmentosa in humans. This study was conducted to test whether CNTF prevents photoreceptor cell loss in XLPRA2, an early onset canine model of X-linked retinitis pigmentosa caused by a frameshift mutation in RPGR exon ORF15. Four different treatment regimens of CNTF were tested in XLPRA2 dogs. Under anesthesia, the animals received at different ages an intravitreal injection of 12 μg of CNTF in the left eye. The right eye served as a control and was injected …
A Meiotic Linkage Map Of The Silver Fox, Aligned And Compared To The Canine Genome, Anna V. Kukekova, Lyudmila N. Trut, Irina N. Oskina, Jennifer L. Johnson, Svetlana V. Temnykh, Anastasiya V. Kharlamova, Darya V. Shepeleva, Rimma G. Gulievich, Svetlana G. Shikhevich, Alexander S. Graphodatsky, Gustavo D. Aguirre, Gregory M. Acland
A Meiotic Linkage Map Of The Silver Fox, Aligned And Compared To The Canine Genome, Anna V. Kukekova, Lyudmila N. Trut, Irina N. Oskina, Jennifer L. Johnson, Svetlana V. Temnykh, Anastasiya V. Kharlamova, Darya V. Shepeleva, Rimma G. Gulievich, Svetlana G. Shikhevich, Alexander S. Graphodatsky, Gustavo D. Aguirre, Gregory M. Acland
Gustavo D. Aguirre, VMD, PhD
A meiotic linkage map is essential for mapping traits of interest and is often the first step toward understanding a cryptic genome. Specific strains of silver fox (a variant of the red fox, Vulpes vulpes), which segregate behavioral and morphological phenotypes, create a need for such a map. One such strain, selected for docility, exhibits friendly dog-like responses to humans, in contrast to another strain selected for aggression. Development of a fox map is facilitated by the known cytogenetic homologies between the dog and fox, and by the availability of high resolution canine genome maps and sequence data. Furthermore, the …
Molecular And Seroprevalence Of Canine Visceral Leishmaniasis In West Anatolia, Turkey, Serkan Bakirci, Hüseyi̇n Bi̇lgi̇n Bi̇lgi̇ç, Onur Köse, Ayça Aksulu, Seli̇n Hacilarlioğlu, Hasan Erdoğan, Tüli̇n Karagenç
Molecular And Seroprevalence Of Canine Visceral Leishmaniasis In West Anatolia, Turkey, Serkan Bakirci, Hüseyi̇n Bi̇lgi̇n Bi̇lgi̇ç, Onur Köse, Ayça Aksulu, Seli̇n Hacilarlioğlu, Hasan Erdoğan, Tüli̇n Karagenç
Turkish Journal of Veterinary & Animal Sciences
Canine leishmaniasis (CanL) is a protozoal disease caused by Leishmania species. Dogs play an important role as a reservoir. The aim of this study is to determine the prevalence of CanL by molecular and serological techniques among stray dogs living in kennels in Aydın, Manisa, and İzmir, located in western Turkey. Blood samples were collected from a total of 191 dogs and analyzed using indirect immunofluorescence antibody test (IFAT) and polymerase chain reaction (PCR). The isolates that tested positive using PCR were further analyzed by real-time PCR for species identification and confirmation. A total of 21 (10.99%) dogs were found …
Diagnostic And Therapeutic Approach To Cardiac Myxosarcoma In A Dog, Meri̇ç Kocatürk, Hakan Salci, Murat Bi̇çer, Ahmet Akkoç, Sai̇m Sağ, Zeki̇ Yilmaz
Diagnostic And Therapeutic Approach To Cardiac Myxosarcoma In A Dog, Meri̇ç Kocatürk, Hakan Salci, Murat Bi̇çer, Ahmet Akkoç, Sai̇m Sağ, Zeki̇ Yilmaz
Turkish Journal of Veterinary & Animal Sciences
A 7-year-old Chow Pei was referred to an animal hospital for the evaluation of a 1-month history of abdominal distension and exercise intolerance. A systolic murmur was auscultated over the tricuspid valve (TV). Thoracic radiographs showed cardiomegaly, right atrial enlargement, and pulmonary edema. Electrocardiography revealed small QRS complexes and a right-bundle brunch block. Echocardiography also showed right atrial enlargement and tricuspid insufficiency due to the presence of a mass on the posterior leaflet of the TV. The mass was excised by intracardiac surgery and histological evaluation revealed myxosarcoma. This is a case report of a diagnostic and therapeutic approach to …
Subarachnoid Transplantation Of Autologous Neurogenically Induced Bone Marrow Derived Mesenchymal Stem Cells For The Treatment Of Fibrocartilaginous Embolic Myelopathy In Two Dogs, Pinar Can, Ömer Beşalti, Eylül Akpinar, Zeynep Aktaş, Ayşe Eser Elçi̇n, Yaşar Murat Elçi̇n
Subarachnoid Transplantation Of Autologous Neurogenically Induced Bone Marrow Derived Mesenchymal Stem Cells For The Treatment Of Fibrocartilaginous Embolic Myelopathy In Two Dogs, Pinar Can, Ömer Beşalti, Eylül Akpinar, Zeynep Aktaş, Ayşe Eser Elçi̇n, Yaşar Murat Elçi̇n
Turkish Journal of Veterinary & Animal Sciences
The objective of this study was to investigate the effects of autologous neurogenically induced bone marrow-derived mesenchymal stem cells (NIBM-MSCs) in two dogs suspected to have fibrocartilaginous embolic myelopathy (FCEM). Both dogs were paraplegic without deep pain perception (DPP) and tentatively diagnosed by MRI. Autologous NIBM-MSCs (5 × 106) were transplanted into the lumbar subarachnoid space two times with a 21-day interval for each patient. Based on a 21-month follow-up of the treated animals, the transplantation of NIBM-MSCs seems to be promising in subjects with FCEM lacking DPP.
Immunohistochemical Evaluation Of Canine And Felinemerkel Cell Tumors?A Report Of Two Cases, Mateusz Mikiewicz, Iwona Otrocka-Domagala, Katarzyna Pazdzior-Czapula, Michal Gesek, Anna Mikolajczyk, Agnieszka Blacha
Immunohistochemical Evaluation Of Canine And Felinemerkel Cell Tumors?A Report Of Two Cases, Mateusz Mikiewicz, Iwona Otrocka-Domagala, Katarzyna Pazdzior-Czapula, Michal Gesek, Anna Mikolajczyk, Agnieszka Blacha
Turkish Journal of Veterinary & Animal Sciences
Merkel cell tumors, a type of cutaneous round-cell tumors, are rarely observed in dogs and cats. This tumor type originates from cutaneous neuroendocrine cells. In the present study, the morphology of canine and feline Merkel cell tumors and their immunoexpression of neuron-specific enolase, cytokeratin, chromogranin A, Ki67, and metallothionein were evaluated using histopathological and immunohistochemical methods. The canine Merkel cell tumor displayed a diffuse morphological pattern, whereas the feline tumor displayed a solid morphological pattern. Both tumors were positive for neuron-specific enolase and cytokeratin, but negative for chromogranin A. The Ki67 indexes in the canine and feline tumors were 7% …
Development Of A Novel In Vivo Corneal Fibrosis Model In The Dog, K. M. Gronkiewicz, Elizabeth A. Giuliano, K. Kuroki, F. Bunyak, Ajay Sharma, L. B. C. Teixeira, C. W. Hamm, R. R. Mohan
Development Of A Novel In Vivo Corneal Fibrosis Model In The Dog, K. M. Gronkiewicz, Elizabeth A. Giuliano, K. Kuroki, F. Bunyak, Ajay Sharma, L. B. C. Teixeira, C. W. Hamm, R. R. Mohan
Pharmacy Faculty Articles and Research
The aim of this study was to develop a novel in vivo corneal model of fibrosis in dogs utilizing alkali burn and determine the ability of suberanilohydroxamic acid (SAHA) to inhibit corneal fibrosis using this large animal model. To accomplish this, we used seven research Beagle dogs. An axial corneal alkali burn in dogs was created using 1 N NaOH topically. Six dogs were randomly and equally assigned into 2 groups: A) vehicle (DMSO, 2 μL/mL); B) anti-fibrotic treatment (50 μM SAHA). The degree of corneal opacity, ocular health, and anti-fibrotic effects of SAHA were determined utilizing the Fantes grading …
Detection Of Helicobacter Heilmannii Type Ii And Helicobacter Pylori Indogs And Their Role In The Development Of Gastritis, Si̇nem Ülgen, Sevgi̇ Ergi̇n, Gülbi̇n Şennazli, Utku Bakirel
Detection Of Helicobacter Heilmannii Type Ii And Helicobacter Pylori Indogs And Their Role In The Development Of Gastritis, Si̇nem Ülgen, Sevgi̇ Ergi̇n, Gülbi̇n Şennazli, Utku Bakirel
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to detect the presence of Helicobacter pylori and Helicobacter heilmannii type II in dogs and evaluate the role of Helicobacter spp. İn chronic gastritis. Gastroscopy was performed in a total of 40 dogs (22 symptomatic and 18 asymptomatic) admitted to the small animal clinic of İstanbul University. In this study, the density of spiral bacteria and the degree and type of gastritis by histopathology were determined. Rapid urease tests were performed on gastric biopsy samples, and the species identity was determined using nested polymerase chain reaction to assess for the presence of H. Heilmannii …