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80 and over;; Brachytherapy/ methods;; Brain Neoplasms/ radiotherapy/secondary/ surgery;; Cesium Radioisotopes/adverse effects/ therapeutic use;; Combined Modality Therapy;; Disease-Free Survival;; Endpoint Determination;; Female;; Follow-Up Studies;; Humans;; Intraoperative Care/ methods;; Male;; Middle Aged;; Neurosurgical Procedures/adverse effects/ methods;; Prospective Studies;; Survival Analysis;; 125I = iodine-125;; 131Cs;; 131Cs = cesium-131;; FFP = freedom from progression;; OS = overall survival;; QOL = quality of life;; RTOG = Radiation Therapy Oncology Group;; SRS = stereotactic radiosurgery;; WBRT = whole-brain radiotherapy;; brachytherapy;; cesium-131;; metastasis;; oncology;; radiation;; radiotherapy
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Full-Text Articles in Medicine and Health Sciences
Phase I/Ii Study Of Resection And Intraoperative Cesium-131 Radioisotope Brachytherapy In Patients With Newly Diagnosed Brain Metastases., A. G. Wernicke, B. Parashar, D. Nori, K. S. Clifford Chao, P. Christos, I. Kovanlikaya, S. Pannullo, J. A. Boockvar, P. E. Stieg, T. H. Schwartz
Phase I/Ii Study Of Resection And Intraoperative Cesium-131 Radioisotope Brachytherapy In Patients With Newly Diagnosed Brain Metastases., A. G. Wernicke, B. Parashar, D. Nori, K. S. Clifford Chao, P. Christos, I. Kovanlikaya, S. Pannullo, J. A. Boockvar, P. E. Stieg, T. H. Schwartz
Journal Articles
OBJECT: Resected brain metastases have a high rate of local recurrence without adjuvant therapy. Adjuvant whole-brain radiotherapy (WBRT) remains the standard of care with a local control rate > 90%. However, WBRT is delivered over 10-15 days, which can delay other therapy and is associated with acute and long-term toxicities. Permanent cesium-131 ((131)Cs) implants can be used at the time of metastatic resection, thereby avoiding the need for any additional therapy. The authors evaluated the safety, feasibility, and efficacy of a novel therapeutic approach with permanent (131)Cs brachytherapy at the resection for brain metastases. METHODS: After institutional review board approval was …