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Full-Text Articles in Medicine and Health Sciences
Fine Mapping Seronegative And Seropositive Rheumatoid Arthritis To Shared And Distinct Hla Alleles By Adjusting For The Effects Of Heterogeneity, B. Han, D. Diogo, S. Eyre, H. Kallberg, A. Zhernakova, J. Bowes, L. Padyukov, Y. Okada, P. K. Gregersen, S. Raychaudhuri, +8 Additional Authors
Fine Mapping Seronegative And Seropositive Rheumatoid Arthritis To Shared And Distinct Hla Alleles By Adjusting For The Effects Of Heterogeneity, B. Han, D. Diogo, S. Eyre, H. Kallberg, A. Zhernakova, J. Bowes, L. Padyukov, Y. Okada, P. K. Gregersen, S. Raychaudhuri, +8 Additional Authors
Journal Articles
Despite progress in defining human leukocyte antigen (HLA) alleles for anti-citrullinated-protein-autoantibody-positive (ACPA(+)) rheumatoid arthritis (RA), identifying HLA alleles for ACPA-negative (ACPA(-)) RA has been challenging because of clinical heterogeneity within clinical cohorts. We imputed 8,961 classical HLA alleles, amino acids, and SNPs from Immunochip data in a discovery set of 2,406 ACPA(-) RA case and 13,930 control individuals. We developed a statistical approach to identify and adjust for clinical heterogeneity within ACPA(-) RA and observed independent associations for serine and leucine at position 11 in HLA-DRbeta1 (p = 1.4 x 10(-13), odds ratio [OR] = 1.30) and for aspartate at …