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Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Cytotoxicity Of Nickel Ions For Human Osteoblasts In The Context Of Orthodontic Treatment In Humans And Animals, Marcin Mikulewicz, Katarzyna Chojnacka, Iwona Kochanowska, Agnieszka Dziewicka, Maciej Janeczek, Jerzy Cieplik, Aleksander Chrószcz
Cytotoxicity Of Nickel Ions For Human Osteoblasts In The Context Of Orthodontic Treatment In Humans And Animals, Marcin Mikulewicz, Katarzyna Chojnacka, Iwona Kochanowska, Agnieszka Dziewicka, Maciej Janeczek, Jerzy Cieplik, Aleksander Chrószcz
Turkish Journal of Veterinary & Animal Sciences
In the present work, the biocompatibility of orthodontic devices was tested by the propagation of human osteoblasts. A different methodological approach was applied. Since the materials used in human and veterinary orthodontics (not in implantology) had been tested, osteoblasts were not implanted on the surface of the biomaterial, but have been cultured in the medium containing the products of corrosion. In the present work, osteoblasts were propagated in the medium spiked with Ni(II) salt versus the control. Osteoblast cells (live, dead, and total) were counted under light microscope. The statistical significance of the differences between the experimental and control groups …
Phase Composition Control Of Calcium Phosphate Nanoparticles For Tunable Drug Delivery Kinetics And Treatment Of Osteomyelitis. Part 2: Antibacterial And Osteoblastic Response, Vuk Uskoković, Tejal A. Dasai
Phase Composition Control Of Calcium Phosphate Nanoparticles For Tunable Drug Delivery Kinetics And Treatment Of Osteomyelitis. Part 2: Antibacterial And Osteoblastic Response, Vuk Uskoković, Tejal A. Dasai
Pharmacy Faculty Articles and Research
Osteomyelitis has been traditionally treated by the combination of long-term antibiotic therapies and surgical removal of diseased tissue. The multifunctional material was developed in this study with the aim to improve this therapeutic approach by: (a) enabling locally delivered and sustained release of antibiotics at a tunable rate, so as to eliminate the need for repetitive administration of systemically distributed antibiotics; and (b) controllably dissolving itself, so as to promote natural remineralization of the portion of bone lost to disease. We report hereby on the effect of the previously synthesized calcium phosphates (CAPs) with tunable solubilities and drug release time …