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Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

2013

Jennifer R Niebyl

Double-Blind Method

Discipline

Articles 1 - 5 of 5

Full-Text Articles in Medicine and Health Sciences

Treatment Of Premature Labor With Indomethacin., D. Blake, Jennifer Niebyl, R. White, K. Kumor, N. Dubin, J. Robinson, P. Egner Jun 2013

Treatment Of Premature Labor With Indomethacin., D. Blake, Jennifer Niebyl, R. White, K. Kumor, N. Dubin, J. Robinson, P. Egner

Jennifer R Niebyl

No abstract provided.


Inhibition Of Arachidonic Acid Metabolism In The Perinatal Period: Pharmacology, Clinical Application, And Potential Adverse Effects, F. Witter, Jennifer Niebyl May 2013

Inhibition Of Arachidonic Acid Metabolism In The Perinatal Period: Pharmacology, Clinical Application, And Potential Adverse Effects, F. Witter, Jennifer Niebyl

Jennifer R Niebyl

No abstract provided.


The Inhibition Of Premature Labor With Indomethacin, Jennifer Niebyl, D. Blake, R. White, K. Kumor, N. Dubin, J. Robinson, P. Egner May 2013

The Inhibition Of Premature Labor With Indomethacin, Jennifer Niebyl, D. Blake, R. White, K. Kumor, N. Dubin, J. Robinson, P. Egner

Jennifer R Niebyl

We administered indomethacin orally for the treatment of premature labor in a prospective, randomized, double-blind fashion, and all infants were followed up. Indomethacin was significantly more effective than placebo in inhibition of premature labor during a 24-hour course of therapy, with treatment failure during therapy occurring in only one of 15 indomethacin-treated patients compared to nine of 15 placebo-treated patients (p less than 0.01). Mean plasma concentrations of indomethacin were approximately 0.8 micrograms/ml at both 4 and 12 hours after administration. Mean plasma levels of 15-oxo-13,14-dihydroprostaglandin F2 alpha (PGFM) were similar in the two groups before treatment, decreased markedly in …


Treatment Of Premature Labor With Indomethacin, D. Blake, Jennifer Niebyl, R. White, K. Kumor, N. Dubin, J. Robinson, P. Egner May 2013

Treatment Of Premature Labor With Indomethacin, D. Blake, Jennifer Niebyl, R. White, K. Kumor, N. Dubin, J. Robinson, P. Egner

Jennifer R Niebyl

No abstract provided.


Vitamin B6 Is Effective Therapy For Nausea And Vomiting Of Pregnancy: A Randomized, Double-Blind Placebo-Controlled Study, V. Sahakian, D. Rouse, S. Sipes, N. Rose, Jennifer Niebyl May 2013

Vitamin B6 Is Effective Therapy For Nausea And Vomiting Of Pregnancy: A Randomized, Double-Blind Placebo-Controlled Study, V. Sahakian, D. Rouse, S. Sipes, N. Rose, Jennifer Niebyl

Jennifer R Niebyl

Fifty-nine women completed a randomized, double-blind placebo-controlled study of pyridoxine hydrochloride (vitamin B6) for the treatment of nausea and vomiting of pregnancy. Thirty-one patients received vitamin B6, 25-mg tablets orally every 8 hours for 72 hours, and 28 patients received placebo in the same regimen. Patients were categorized according to the presence of vomiting: severe nausea (score greater than 7) or mild to moderate nausea (score of 7 or less). The severity of nausea (as graded on a visual analogue scale of 1-10 cm) and the number of patients with vomiting over a 72-hour period were used to evaluate response …