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Fish Oil And Indomethacin In Combination Potently Reduce Dyslipidemia And Hepatic Steatosis In Ldlr-/- Mice, Ganesan Murali, Ginger L. Milne, Corey Webb, Ann B. Stewart, Ryan P. Mcmillan, Brandon C. Lyle, Matthew W. Hulver, Viswanathan Saraswathi
Fish Oil And Indomethacin In Combination Potently Reduce Dyslipidemia And Hepatic Steatosis In Ldlr-/- Mice, Ganesan Murali, Ginger L. Milne, Corey Webb, Ann B. Stewart, Ryan P. Mcmillan, Brandon C. Lyle, Matthew W. Hulver, Viswanathan Saraswathi
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Fish oil (FO) is a potent anti-inflammatory and lipid-lowering agent. Because inflammation can modulate lipid metabolism and vice versa, we hypothesized that combining FO with cyclooxygenase inhibitors (COXIBs), well-known anti-inflammatory drugs, can enhance the anti-inflammatory and lipid-lowering effect of FO. LDLR-/- mice were fed a high fat diet supplemented with 6% olive oil or FO for 12 wk in the presence or absence of indomethacin (Indo, 6mg/liter drinking water). FO reduced plasma total cholesterol by 30% but in combination with Indo, exerted a greater decrease (44%). The reduction of liver cholesterol ester (CE) and triglycerides (TG) by FO (63% …