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Mechanisms Of Mouse Hepatitis Virus Entry Into Cells, Philip J. Koehler, Kristina Cade, Fiora D. Zoga, Susan T. Hingley
Mechanisms Of Mouse Hepatitis Virus Entry Into Cells, Philip J. Koehler, Kristina Cade, Fiora D. Zoga, Susan T. Hingley
Research Day
Background: Viruses can enter cells through several mechanisms, two common ones being clathrin-mediated and caveolin-mediated endocytosis. The clathrin pathway delivers viral particles to endosomes, with subsequent acidification of the endosome and endosome/lysosome fusion often a prerequisite for release of the viral genome into the cytoplasm. The caveolin-mediated pathway delivers virus initially into vesicles called caveosomes, which have a neutral pH, before viral uncoating occurs. Viral entry pathways can be examined by using various drugs to inhibit the different endocytosis pathways, as well as by siRNA technology to down-regulate expression of clathrin or caveolin proteins on the surface of host …