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The Human Pathogen Clostridium Dificle: A Look At A Putative Involved In Protection From Oxidative Stress, Tashinea Lee, Francis E. Jenney
The Human Pathogen Clostridium Dificle: A Look At A Putative Involved In Protection From Oxidative Stress, Tashinea Lee, Francis E. Jenney
Research Day
Background: Hospital acquired infections due to Clostridium difficile (C. diff) is associated with nosocomial diarrhea and pseudomembranous colitis. Using a published microarray analysis of C. diff strain 630, several open reading frames (ORFs) were noted for their upregulation under different environmental stresses. One of these genes (CD1134) is a putative glyoxalase I. The glyoxalase enzymes detoxify a side product of glycolysis, methylglyoxal, and use metals as a cofactor.