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Imp2 Expression In The Mouse Nervous System, Sarah E. Chmielewski, Paige E. Black, Tiffany M. Holmes, Kelly S. Lau, Gary J. Bassell
Imp2 Expression In The Mouse Nervous System, Sarah E. Chmielewski, Paige E. Black, Tiffany M. Holmes, Kelly S. Lau, Gary J. Bassell
Research Day
Background: Insulin-like growth factor-II (IGF-II) mRNA-binding protein-2 (IMP2) is one of the three homologs (IMP1-3) that play important roles in the posttranscriptional regulation of gene expression in several tissues. IMP1/ZBP1 (zipcode binding protein) has been shown to play important roles in axon guidance and regeneration by regulating the localization and translation of specific mRNAs. However, the function of IMP2 is least understood, largely because an isoform-specific antibody is not available, which makes the conventional techniques to locate protein expression not feasible.