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Full-Text Articles in Medicine and Health Sciences
High Serum Cu And Cu/Zn Ratios Correlate With Impairments In Bone Density, Physical Performance And Overall Health In A Population Of Elderly Men With Frailty Characteristics, Eric D. Gaier, Alison Kleppinger, Richard E. Mains, Anne M. Kenny, Betty A. Eipper
High Serum Cu And Cu/Zn Ratios Correlate With Impairments In Bone Density, Physical Performance And Overall Health In A Population Of Elderly Men With Frailty Characteristics, Eric D. Gaier, Alison Kleppinger, Richard E. Mains, Anne M. Kenny, Betty A. Eipper
UCHC Articles - Research
Serum Cu levels rise with age and high Cu/Zn ratios are linked with multiple-cause mortality in the elderly. The relationships of these parameters to measures of musculoskeletal health and frailty have not yet been analyzed. We used inductively coupled mass spectrometry to assess serum levels of Cu and Zn and probed for relationships between serum Cu levels and the Cu/Zn ratio with specific measures of bone, physical and overall health in a cohort of 144 frail elderly men. Subjects were divided into quintiles based on serum metal levels and comparisons for functional measures were made between the reference (middle) group …