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Association Study Of Candidate Gene Polymorphisms And Obesity In A Young Mexican-American Population From South Texas, Jorge Duran-Gonzalez, Ixiu Ortiz, Enrique Gonzales, Nicole Ruiz, Manti Ortiz, Arthur Gonzalez, Edna K. Sanchez, Eugenia Curet, Susan P. Fisher-Hoch, Anne R. Rentfro, Huiqi Qu, Saraswathy Nair
Association Study Of Candidate Gene Polymorphisms And Obesity In A Young Mexican-American Population From South Texas, Jorge Duran-Gonzalez, Ixiu Ortiz, Enrique Gonzales, Nicole Ruiz, Manti Ortiz, Arthur Gonzalez, Edna K. Sanchez, Eugenia Curet, Susan P. Fisher-Hoch, Anne R. Rentfro, Huiqi Qu, Saraswathy Nair
Health & Biomedical Sciences Faculty Publications and Presentations
Background and Aims
Obesity is increasingly a health problem and a risk factor for diabetes in young Mexican-American populations. Genetic association studies in older, mostly non-Hispanic populations have reported that polymorphisms in the candidate genes HSD11B1, CRP, ADIPOQ, PPARG, ANKK1, ABCC8 and SERPINF1 are associated with obesity or diabetes. We analyzed the polymorphisms rs846910, rs1205, rs1501299, rs1801282, rs1800497, rs757110 and rs1136287in these candidate genes, for association with obesity and metabolic traits in a young Mexican-American population from south Texas.
Methods
Genotyping of the seven common SNPs were performed by allelic discrimination assays in 448 unrelated Mexican Americans (median age = …