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Identifying Modulators Of The Development Of Acute Functional Tolerance To Ethanol In Caenorhabditis Elegans., Ka-Po Leung Dec 2011

Identifying Modulators Of The Development Of Acute Functional Tolerance To Ethanol In Caenorhabditis Elegans., Ka-Po Leung

Theses and Dissertations

Alcohol abuse is a problem in our society. There are few treatments available, in part due to the unclear molecular mechanisms of ethanol’s effects. Human studies indicate that there is a genetic component influencing disease susceptibility, and that an individual’s initial response to alcohol can predict their development of addiction. We have taken a forward genetics approach to study one component of initial response, acute functional tolerance (AFT), in Caenorhabditis elegans. We identified bet11, a mutation that causes animals to be defective in the development of AFT. Genetic analysis suggested that the gene that bet11 disrupts participates in a synthetic …


Efficacy Of Acetone And Ethanol In Dehydrating Canine Body Sheets :Before And After Resin Coating, Kriengyot Sajjarengpong, Pawana Chuesiri, Pakorn Prachammuang, Panida Phisiriyuenyong Dec 2011

Efficacy Of Acetone And Ethanol In Dehydrating Canine Body Sheets :Before And After Resin Coating, Kriengyot Sajjarengpong, Pawana Chuesiri, Pakorn Prachammuang, Panida Phisiriyuenyong

The Thai Journal of Veterinary Medicine

The aim of this study was to compare the efficacy of ethanol and acetone in dehydration of canine bodysheets before preservation in resin for a 16-week period. A 10-kg male dog which died of the respiratory failure waspreserved in 10% formalin via common carotid artery at room temperature for 7 days prior to being kept in a freezerat -250C for 7 days. The body of the dog was cut into 2.5-cm-thick sheets with a band saw. The body sheets wereseparately dehydrated for 3 days with either acetone or ethanol. In this study, the color of muscles and fat fromacetone-dehydrated sheets …


Comparison Of Adhesion Of Gutta Percha/Ah Plus® And Resilon/Epiphany® Se™ After A Final Rinse With Different Concentrations Of Ethanol, Suren Paravyan May 2011

Comparison Of Adhesion Of Gutta Percha/Ah Plus® And Resilon/Epiphany® Se™ After A Final Rinse With Different Concentrations Of Ethanol, Suren Paravyan

Theses and Dissertations

The purpose of this study was to evaluate effect of final rinse of ethanol on bond strength in teeth obturated with Gutta Percha (GP)/AH Plus® or Resilon/Epiphany®SE™. Thirty-two extracted human anterior teeth were shaped to size 30, 0.06 taper and subjected to an identical irrigation protocol. Specimens were randomly divided into eight groups according to final irrigating solution (saline, 70%, 95%, 100% ethanol) and obturation material. Two millimeter thick slices were obtained by sectioning each obturated root. Bond strength was determined using micropush-out assay. Data was analyzed using Student’s t-test. Obturation with GP/AH Plus® formed a statistically significant stronger bond …


Alcohol And Hepatitis C Virus--Interactions In Immune Dysfunctions And Liver Damage, Gyongyi Szabo, Jack Wands, Ahment Eken, Natalia Osna, Steven Weinman, Keigo Machida, Joe Wang Mar 2011

Alcohol And Hepatitis C Virus--Interactions In Immune Dysfunctions And Liver Damage, Gyongyi Szabo, Jack Wands, Ahment Eken, Natalia Osna, Steven Weinman, Keigo Machida, Joe Wang

Gyongyi Szabo

Hepatitis C virus infection affects 170 million people worldwide, and the majority of individuals exposed to HCV develop chronic hepatitis leading to progressive liver damage, cirrhosis, and hepatocellular cancer. The natural history of HCV infection is influenced by genetic and environmental factors of which chronic alcohol use is an independent risk factor for cirrhosis in HCV-infected individuals. Both the hepatitis C virus and alcohol damage the liver and result in immune alterations contributing to both decreased viral clearance and liver injury. This review will capture the major components of the interactions between alcohol and HCV infection to provide better understanding …