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University of Nebraska - Lincoln
Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research
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Regulation Of Sterol Transport By Dietary Phytosterol Esters, Trevor J. Carden
Regulation Of Sterol Transport By Dietary Phytosterol Esters, Trevor J. Carden
Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research
LDL cholesterol is associated with the development of atherosclerosis and is therefore considered an important target for intervention to prevent cardiovascular diseases. The inhibition of cholesterol absorption in the small intestine is an attractive approach to lowering plasma cholesterol, one that is exploited by drug therapy as well as dietary supplementation with plant sterols. The mechanism of action of plant sterol esters (PSE) is still incompletely understood, therefore this study was conducted to test the hypothesis that hydrolysis of plant sterol esters is necessary for their cholesterol-lowering effects to be realized.
Male Syrian hamsters were fed diets containing no PSE, …