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Diversity Of The Kir Gene Cluster In An Urban Brazilian Population, D. G. Augusto, L. Zehnder-Alves, M. R. Pincerati, M. P. Martin, Mary Carrington, Maria Luiza Petzl-Erler

Public Health Resources

The activity of natural killer cells depends on the balance between activating and inhibitory signals coming from their receptors. Among these are the killer cell immunoglobulin-like receptors (KIR) that recognize specific HLA class I allotypes. Here we characterized KIR genetic diversity and their HLA ligands in the population of Curitiba, Paraná State (n=164), and compared it with other worldwide populations. The distribution of 2DL4 alleles was also analyzed. The Curitiba population did not differ significantly from European and Euro-descendant populations, but as an admixed population showed higher genetic diversity. We found 27 KIR profiles, many of them uncommon in European …