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Molecular Structures Of Prrsv That Contribute To Prrsv Protective Immunity, Asit K. Pattnaik
Molecular Structures Of Prrsv That Contribute To Prrsv Protective Immunity, Asit K. Pattnaik
School of Veterinary and Biomedical Sciences: Faculty Publications
One of the objectives of the proposal is to delineate the regions of the two glycoproteins (GP2 and GP4) of PRRSV that interact with CD163. Other objectives of the proposal are to generate antibodies to these small regions of the glycoproteins as well as to the full-length proteins for future studies to determine if any of these antibodies possess PRRSV neutralizing activity.
To carry out the studies in the proposed objectives, we generated a series of mutants of GP2 as well as GP4 proteins in which various regions were specifically removed by manipulating the plasmids encoding these proteins. We then …