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Full-Text Articles in Medicine and Health Sciences
White Matter Diffusion Alterations In Normal Women At Risk Of Alzheimer's Disease, Charles D. Smith, Himachandra Chebrolu, Anders H. Andersen, David A. Powell, Mark A. Lovell, Shuling Xiong, Brian T. Gold
White Matter Diffusion Alterations In Normal Women At Risk Of Alzheimer's Disease, Charles D. Smith, Himachandra Chebrolu, Anders H. Andersen, David A. Powell, Mark A. Lovell, Shuling Xiong, Brian T. Gold
Neurology Faculty Publications
Increased white matter mean diffusivity and decreased fractional anisotropy (FA) has been observed in subjects diagnosed with mild cognitive impairment (MCI) and Alzheimer's disease (AD). We sought to determine whether similar alterations of white matter occur in normal individuals at risk of AD. Diffusion tensor images were acquired in 42 cognitively normal right-handed women with both a family history of dementia and at least one apolipoprotein E4 allele. These were compared with images from 23 normal women without either AD risk factor. Group analyses were performed using tract-based spatial statistics. Reduced FA was observed in the fronto-occipital and inferior temporal …
Predictive Validity Of The Updrs Postural Stability Score And The Functional Reach Test, When Compared With Ecologically Valid Reaching Tasks, M. Jenkins, Andrew Johnson, J. Holmes, F. Stephenson, S. Spaulding
Predictive Validity Of The Updrs Postural Stability Score And The Functional Reach Test, When Compared With Ecologically Valid Reaching Tasks, M. Jenkins, Andrew Johnson, J. Holmes, F. Stephenson, S. Spaulding
Andrew M. Johnson
Balance problems and falls are a common concern among individuals with Parkinson's disease (PD). Falls frequently occur during daily activities such as reaching into cupboards in the kitchen or bathroom. This study compared the correlation among two standard postural stability tests - the postural stability score on the Unified Parkinson's Disease Rating Scale (UPDRS) and the Functional Reach Test (FRT) - and ecologically valid reaching tasks that correspond to reaching at different cupboard heights among 20 individuals with PD and 20 age-matched controls. Both the FRT and the UPDRS postural stability tests are quick measures that can be performed during …
An Exploration Of The Burden Experienced By Spousal Caregivers Of Individuals With Parkinson's Disease, Kaitlyn Roland, Mary Jenkins, Andrew Johnson
An Exploration Of The Burden Experienced By Spousal Caregivers Of Individuals With Parkinson's Disease, Kaitlyn Roland, Mary Jenkins, Andrew Johnson
Andrew M. Johnson
Although previous research has attempted to identify the needs of caregivers for individuals with Parkinson's disease (PD), most has focused on the demands associated with the physical needs of the patient, and not on "mental burden." This study used the repertory grid method to capture the full range of caregivers' subjective experience, quantify their perceptions, and to acquire information that might be useful in directing remediation attempts. Within this sample, caregivers reported far greater burden from "mental stress" (e.g., worrying about individual's safety) than from "physical stress" (e.g., lifting individual into bed). Specifically, caregivers were primarily concerned about spousal safety, …