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Neuropeptide Y Is Expressed By Osteocytes And Can Inhibit Osteoblastic Activity, John C. Igwe, Xi Jiang, Frane Paic, Li Ma, Douglas J. Adams, Carol C. Pilbeam, Ivo Kalajzic
Neuropeptide Y Is Expressed By Osteocytes And Can Inhibit Osteoblastic Activity, John C. Igwe, Xi Jiang, Frane Paic, Li Ma, Douglas J. Adams, Carol C. Pilbeam, Ivo Kalajzic
UCHC Articles - Research
Osteocytes are the most abundant osteoblast lineage cells within the bone matrix. They respond to mechanical stimulation and can participate in the release of regulatory proteins that can modulate the activity of other bone cells. We hypothesize that neuropeptide Y (NPY), a neurotransmitter with regulatory functions in bone formation, is produced by osteocytes and can affect osteoblast activity. To study the expression of NPY by the osteoblast lineage cells, we utilized transgenic mouse models in which we can identify and isolate populations of osteoblasts and osteocytes. The Col2.3GFP transgene is active in osteoblasts and osteocytes, while the DMP1 promoter drives …