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Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
The Regulation Of The Ospz And Orf-2 Promoters In The Shigella Flexneri By The Virulence Factor Virb, David Basta, Helen J. Wing
The Regulation Of The Ospz And Orf-2 Promoters In The Shigella Flexneri By The Virulence Factor Virb, David Basta, Helen J. Wing
Undergraduate Research Opportunities Program (UROP)
Shigella flexneri is a pathogenic bacterium that is the causative agent of shigellosis, an illness characterized by severe dysentery. Shigella carries many of its virulence genes on a large virulence plasmid and consequently this plasmid is the focus of research in the Wing lab. My research focuses on the transcriptional regulation of a newly identified gene called ospZ. This gene’s protein product is secreted outside the bacterial cell and assists in polymorphonuclear leukocyte migration, a function that is believed to enhance the virulence of Shigella. Many genes encoded by the Shigella virulence plasmid are regulated by the transcription factor VirB, …
Pdest Fg12-Cmv Dsred Vector, Jarod Wolffis, Sheri L. Holmen
Pdest Fg12-Cmv Dsred Vector, Jarod Wolffis, Sheri L. Holmen
Undergraduate Research Opportunities Program (UROP)
Melanoma is the most rapidly increasing malignancy among young people in the United States. If detected early, the disease is easily treated; however, once the disease has metastasized it is largely refractory to conventional therapies and is associated with a high mortality rate. The development of human cancer from a pre-malignant primary tumor to a metastatic lesion that develops at secondary sites is thought to be a multi-step process, requiring many genetic and epigenetic events that provide a growth advantage to cells. It is still unclear which of the many genetic changes in human cancers are required for metastasis. Therefore, …
Mutations To Antibiotic Resistance During Stringent Response In B. Subtilis, Chad Hansen, Ronald E. Yasbin, Eduardo A. Robleto
Mutations To Antibiotic Resistance During Stringent Response In B. Subtilis, Chad Hansen, Ronald E. Yasbin, Eduardo A. Robleto
Undergraduate Research Opportunities Program (UROP)
The relA gene in Bacillus subtilis controls a variety of factors during the stringent response which is a response to starvation of amino acids. The stringent response inhibits DNA synthesis and transcription of genes of tRNA, rRNA, and ribosomal proteins and promotes synthesis of the required amino acids. The objective of my project is to determine if a strain of B. subtilis that has a knockout mutation for the relA gene will accumulate a higher number of mutations that confer resistance to antibiotics that inhibit translation. It is proposed that because the relA gene inhibits transcription of ribosomal proteins, a …
Expression Of An Alternate Splice Form Of Bmi-1 In Multiple Myeloma, Adam Austin, Kristine Veys, Debbie Wong, James Tung
Expression Of An Alternate Splice Form Of Bmi-1 In Multiple Myeloma, Adam Austin, Kristine Veys, Debbie Wong, James Tung
Undergraduate Research Opportunities Program (UROP)
The concept of “tumor stem cells” has garnered much attention in the last few years. Tumor stem cells are believed to exist among a heterogeneous group of cells that constitute a tumor. These tumor stem cells often express genes that are important for stem cell function, cell division, and maintenance of pluripotent state in stem cells. Stem cell or stem cell maintenance genes such as SALL 4 and Bmi-1 are often seen in these cancer cells and contribute to self-renewing divisions and cancer cell survival. In particular, high expression of Bmi-1 (B lymphoma mouse Moloney leukemia virus insertion region), a …
Survival Of Shigella Flexneri In Swimming Pool Water, Monique Gomez, Helen J. Wing
Survival Of Shigella Flexneri In Swimming Pool Water, Monique Gomez, Helen J. Wing
Undergraduate Research Opportunities Program (UROP)
Shigellosis is a disease caused by the pathogenic bacterium Shigella flexneri. The bacterium causes bloody diarrheadiarrhea, fever and abdominal pain. Infections can be and may cause fatal. . The disease may also cause bloody diarrhea and intense intestinal crampings. In the United States, there have been many outbreaks of shigellosis have been traced back to associated with inadequately disinfectedchlorinated public swimming pools and wading pools. These outbreaks of sShigellosis are most commonly seen among small children who play in these pools. . My goal is to determine how well Shigella survives in freshly chlorinated pool water and in pool water …
Undergraduate Research Opportunities Program, University Of Nevada Las Vegas, College Of Sciences
Undergraduate Research Opportunities Program, University Of Nevada Las Vegas, College Of Sciences
Undergraduate Research Opportunities Program (UROP)
No abstract provided.