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Effects Of Smoking And Gender On Tetrahydroisoquinolines And Beta-Carbolines In A Healthy Population And During Alcohol Detoxification, Satjit Singh Brar
Effects Of Smoking And Gender On Tetrahydroisoquinolines And Beta-Carbolines In A Healthy Population And During Alcohol Detoxification, Satjit Singh Brar
Theses and Dissertations
The purpose of this investigation was to evaluate the effects of smoking and gender on 1) tetrahydroisoquinolines (TIQs) and beta-carbolines (BCs) in a population of healthy subjects and 2) TIQs in an alcohol-dependent population undergoing in-patient detoxification. Comparison in plasma TIQs between the populations was additionally conducted. To support the clinical investigations, a HPLC-FD method was developed and validated to assess plasma concentrations of BCs, harman and norharman, while a HPLC-ESI-MS/MS method was validated to quantify the TIQs, R/S-salsolinol along with dopamine. Forty-one young volunteers were recruited including 19 nonsmokers (NS), 11 light smokers (LS) and 11 heavy smokers (HS), …