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Electrical Behavior Of Non-Aqueous Formulations: Role Of Electrostatic Interactions In Pressurized Metered Dose Inhalers (Pmdis), Reshma Kotian

Theses and Dissertations

Aerosol electrostatics is an important property of pharmaceutical aerosols. The electrostatic properties of pMDI aerosols have been shown to be a function of both formulation and packaging components. The modified ELPI enables measurement of aerosol charge as a function of particle size, and the simultaneous determination of the mass distribution using chemical analysis. However, in order to fully assess the cause and effects of aerosol electrostatics in terms of its biological and regulatory implications, it is necessary to understand the basic charging mechanisms inside the pMDI formulation.

Electrical resistivity and zeta potential measurements confirmed the presence of charged species within …