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Full-Text Articles in Medicine and Health Sciences
Intravenous Nicotine Conditions A Place Preference In Rats Using An Unbiased Design, Jamie L. Wilkinson, Rick A. Bevins
Intravenous Nicotine Conditions A Place Preference In Rats Using An Unbiased Design, Jamie L. Wilkinson, Rick A. Bevins
Department of Psychology: Faculty Publications
The rewarding effects of nicotine contribute to the chronic use of tobacco products. The place conditioning task, a widely used pre-clinical model to study drug reward, has lead to mixed results in rats when nicotine was administered subcutaneously or intraperitoneally; intravenously administered nicotine has not been examined. Further, much of the research demonstrating a nicotine-conditioned place preference in rats has used a biased design making these results susceptible to nonreward interpretations. The present study assessed whether intravenous (IV) nicotine would condition a place preference in an unbiased design and evaluated important behavioral parameters: nicotine dose, number of conditioning trials, and …
Competition Between The Conditioned Rewarding Effects Of Cocaine And Novelty, Carmela M. Reichel, Rick A. Bevins
Competition Between The Conditioned Rewarding Effects Of Cocaine And Novelty, Carmela M. Reichel, Rick A. Bevins
Department of Psychology: Faculty Publications
Access to novelty might provide an alternative learning history that competes with conditioned drug reward. We tested this suggestion in rats using a place conditioning procedure with cocaine and novelty. In Experiment 1, rats were conditioned with cocaine to prefer one side of an apparatus. In a subsequent phase, cocaine exposure continued; however, on the unpaired side, separate group of rats had access to novel objects, cocaine injections, or saline with no objects. Pairings with novel objects or cocaine shifted a preference away from the cocaine-paired environment during drug-free and drug-challenge tests. Experiment 2 tested novelty’s impact when cocaine exposure …