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Experimental Transmission Of Chronic Wasting Disease Agent From Mule Deer To Cattle By The Intracerebral Route, Amir N. Hamir, Robert A. Kunkle, Randall C. Cutlip, Janice M. Miller, Katherine I. O'Rourke, Elizabeth S. Williams, Michael W. Miller, Mick J. Stack, Melanie J. Chaplin, Jügen A. Richt

Other Publications in Zoonotics and Wildlife Disease

This communication reports final observations on experimental transmission of chronic wasting disease (CWD) from mule deer to cattle by the intracerebral route. Thirteen calves were inoculated intracerebrally with brain suspension from mule deer naturally affected with CWD. Three other calves were kept as uninoculated controls. The experiment was terminated 6 years after inoculation. During that time, abnormal prion protein (PrP^res) was demonstrated in the central nervous system (CNS) of 5 cattle by both immunohistochemistry and Western blot. However, microscopic lesions suggestive of spongiform encephalopathy (SE) in the brains of these PrP^res-positive animals were subtle in 3 …