Medicine and Health Sciences Commons^™

Faculty And Program Predictors Of Pass Rates Of Graduates Of Nursing Programs In West Virginia On The National Council Licensure Examination For Registered Nurses 1991 To 2000, Lynda F. Skinner Turner

Theses, Dissertations and Capstones

The purpose of this study was to investigate the relationship between mean student program scores on standardized pre-graduation nursing tests, program attendance policies, grading scales, policies on repeating nursing courses, faculty turnover, degree, teaching experience, clinical nursing experience, part-time faculty, national certification, and NCLEX-RN success in West Virginia nursing programs from 1991-2000. A causal comparative and correlational design was used to investigate the relationship between the dependent variable of NCLEX-RN pass rates and the independent variables. The population of this study consisted of 19 undergraduate nursing programs preparing graduates for entry into practice as registered nurses. Data collection tools utilized …

Effects Of Aging On Pressure-Induced Mapk Activation In The Rat Aorta, Kevin M. Rice

Theses, Dissertations and Capstones

With age, the cardiovascular system experiences substantial alterations in cellular morphology and function. The factors regulating these changes are unknown; however, the mitogen activated protein kinase (MAPK) pathways have emerged as critical components for mediating numerous cellular responses including control of cell growth, differentiation and adaptation. Here we compare the expression, basal activation and the ability of increased pressure to activate the MAPK pathways in adult (6 month old), aged (30 month old) and very aged (36 month old) Fischer 344 x Brown Norway F1 Hybrid rats. Histochemical analysis demonstrated an age-related increase in tunica media thickness of approximately 11% …

The Effects Of Childhood Obesity On Self-Esteem, Heather L. Paxton

Theses, Dissertations and Capstones

Obesity is a growing health problem affecting children in the United States. The prevalence of obesity has increased dramatically over the past 10 years across virtually all populations and age groups. Recent data suggest that 15 percent of U.S. children are severely overweight or obese (National Center for Health Statistics, 2002) . Obese children are at risk for significant health problems, but also face many psychological and social consequences, including low self-esteem. Children who are obese face an increased risk of emotional problems lasting well into adulthood. Factors such as peer rejection, weight-related teasing, and internalized social standards play a …

The Effectiveness Of Memory Training Programs In Improving The Subjective Memory Characteristics Of Healthy Older Adults With Memory Complaints : A Meta-Analysis, Kimilee Y. Wilson

Theses, Dissertations and Capstones

The focus of this study was to examine the effectiveness of memory training programs in improving the metamemory (i.e., subjective memory characteristics) of healthy older adults by integrating recent research findings in a meta-analysis. In particular, the following research questions were proposed: (a) How effective are memory training programs in improving the subjective memory characteristics of healthy older adults with memory complaints? (b) Which components of the memory training programs increase the effectiveness of memory training (in terms of metamemory characteristics)? (c) How do the results of this meta-analysis compare to those reported by Floyd and Scogin (1997)? Studies that …

Effect Of Dna Base Modification On Polymerase Chain Reaction Efficiency And Fidelity, Jan A. Sikorsky

Theses, Dissertations and Capstones

Polymerase stop assays, used to quantify DNA damage, assume single lesions are sufficient to block thermostable DNA polymerase progression. To explore this assumption, 90 base oligonucleotides containing normal or modified DNA bases were amplified using real-time PCR. Data implied that the PCR efficiency was influenced to differing degrees depending on which base lesion was present on the input oligonucleotide; specifically, while reactions with templates containing a single 8-oxo-7,8-dihydro-2í-deoxyguanosine (8-oxodG) were not noticeably altered, the presence of a single 8-oxo-7,8-dihydro-2í-deoxyadenosine, an abasic site, or a cis-syn thymidine dimer (TT dimer) dramatically delayed amplification. In addition, the presence of two tandem 8-oxodGs …

A Historical Review Of Secondary School Athletic Training Coverage In West Virginia, Brian W. Potter

Theses, Dissertations and Capstones

The purpose of this research is to review the history of athletic training in the secondary schools of West Virginia, as well as to determine how appropriate the current level of athletic healthcare is for West Virginia’s secondary school athletes. Participation surveys from the WVSSAC, membership statistics from the NATA, Friday night football game reports, and documents from the WVDE were used to gather data. Since 1988 the total number of high schools with football and number of football athletes has decreased, while the total number of certified athletic trainers (ATCs) in West Virginia has increased. The number of ATCs …

Mechanisms Of Growth Hormone Enhancement Of Excitatory Synaptic Transmission In Hippocampus, Ghada Saad Zaglool Ahmed Mahmoud

Theses, Dissertations and Capstones

Growth hormone (GH) deficiency is associated with impaired learning and memory. One possible target for GH effects on memory is the hippocampus, a brain region containing GH receptors (GHRs). To determine if GH acutely alters hippocampal function, recombinant human GH (rhGH) was applied to in vitro rat hippocampal brain slices. Extracellular recordings were used to assess effects of GH on the field EPSP (fEPSP) and long-term potentiation (LTP) of the fEPSP. GHR expression was measured in GH-treated and control rat hippocampal slices using RT-PCR. The GH signaling pathway was investigated by studying the effect of GH on the fEPSP after …

Discovering The Barriers To Health-Promoting Lifestyles Among Appalachian Veterans With Uncontrolled Hypertension, Tara L. Porter

Theses, Dissertations and Capstones

Introduction: The purpose of this study was to discover the barriers to health promoting lifestyles among the Appalachian veteran population with uncontrolled hypertension.

Design: A quantitative research study was conducted over five months using a non-experimental, descriptive research design. Pender’s Health Promotion Model served as the study’s framework. Subjects were recruited from a primary care setting through advertisement within the hospital. A convenience sample of thirty-two subjects was obtained.

Method: The Health Promotion Lifestyle Profile (HPLP) II survey assessed for barriers to controlled hypertension in the following areas: health-promoting lifestyle, health responsibility, stress management, spiritual growth, interpersonal relationships, nutrition, and …

Convergence Analysis Of Mcmc Method In The Study Of Genetic Linkage With Missing Data, Diana Fisher

Theses, Dissertations and Capstones

Computational infeasibility of exact methods for solving genetic linkage analysis problems has led to the development of a new collection of stochastic methods, all of which require the use of Markov chains. The purpose of this work is to investigate the complexities of missing data in pedigree analysis using the Monte Carlo Markov Chain (MCMC) method as compared to the exact results. Also, we attempt to determine an association between missing data in a familial pedigree and the convergence to stationarity of a descent graph Markov chain implemented in the stochastic method for parametric linkage analysis.

In particular, we will …

Effects Of Tamoxifen On Mitochondrial Nos Activity: Alteration In The Intramitochondrial Ca2+ Homeostasis, Sandeep S. Joshi

Theses, Dissertations and Capstones

Tamoxifen (Tam) is an anticancer drug that induces oxidative stress and apoptosis via mitochondria- and nitric oxide (NO)-dependent pathways. Here, we report that therapeutic concentrations of Tam stimulate the mitochondrial NO synthase (mtNOS) activity of isolated rat liver mitochondria by increasing the intramitochondrial ionized Ca²⁺ concentration ([Ca²⁺]_m). Tam decreases transmembrane potential (∆ψ) due to increased [Ca²⁺]_m that neutralizes the negative charges of the inner mitochondrial membrane. Thus, the present study reports a novel mechanism for the widely used anti- caner drug, Tam.