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Full-Text Articles in Medicine and Health Sciences
Characterization Of Cytokine Induction And Effects Of Antiviral Treatment In Four Murine Models Of Poxvirus Infection, Corinna W. Knorr
Characterization Of Cytokine Induction And Effects Of Antiviral Treatment In Four Murine Models Of Poxvirus Infection, Corinna W. Knorr
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Cytokine profiles during cowpox virus (CPV) strain Brighton and vaccinia virus (VV) strain Western Reserve infections were characterized in intranasal (i.n.) and intraperitoneal (i .p.) models in BALB/c mice. The time-course of induction and effects of cidofovir treatment on interferon (IFN)-γ, IFN-γ inducible protein (IP)-10, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 were determined. The four models have distinct patterns of cytokine induction. CPV i.p. and VV i.n. infections showed increased induction throughout the time studied. CPV i.n. infection resulted in delayed induction of IFN-γ and IP-10. Cytokine levels were fairly constant during VV i.p. infections. Cidofovir treatment (100 mg/kg/day …
Investigation Of The Toxic Affect Of Manganese On Ruminal Microbial Digestion And Growth, Erin Dearing
Investigation Of The Toxic Affect Of Manganese On Ruminal Microbial Digestion And Growth, Erin Dearing
Undergraduate Honors Capstone Projects
This research investigated the toxic effect of manganese, in a reduced chemical state, on rumen microbial metabolism and growth. The reduced form of manganese is the soluble state found in subsurface waters and has a high red-ox potential. In the study, we investigated the effects of reduced manganese at varying concentrations, on rumen microbial ability to replicate and metabolize carbohydrates. The hypotheses that we tested were as follows: (1) reduced manganese decreases the rate of pH drop associated with rumen culture fermentation of a com based diet and (2) reduced manganese decreases the bacterial growth in rumen culture, as measured …