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Full-Text Articles in Medicine and Health Sciences
A Linkage Study Of Autism Using Multipoint Sib-Pair Analysis, Tamara Rogers
A Linkage Study Of Autism Using Multipoint Sib-Pair Analysis, Tamara Rogers
Theses: Doctorates and Masters
Autism is a severe developmental disorder that was first described by Kanner in 1943. It is characterised by four major criteria: marked social deficits, delay in language development, a restricted range of stereotyped repetitive behaviours and onset of the disease within the first three years of life. The last decade of research has provided support for a strong genetic basis in the aetiology of autism. Firstly, a number of genetic conditions, such as fragile X syndrome, chromosome 15 anomalies and tuberous sclerosis, have been associated with autism. Secondly, family studies have demonstrated that the recurrence risk for autism among siblings …
The Relationship Between Functional And Histological Changes In Muscle Following Eccentric Exercise In Mice, Michael John Newton
The Relationship Between Functional And Histological Changes In Muscle Following Eccentric Exercise In Mice, Michael John Newton
Theses: Doctorates and Masters
Exercise-induced muscle damage (EIMD) is known to be produced by novel or unaccustomed exercise, especially high force eccentric contractions. Histological myofibre disruption, force loss and muscle soreness are associated with EIMD and have implications for sporting performance. Traditional practices of assessing the extent of disruption to the myofibres is by performing needle biopsies and subsequently analysing the histology of the fibres. Recently there has been interest in investigating whether changes in force production and contractile properties of muscle following damaging exercise correlate strongly with the magnitude of disruption to the myofibres. The main aim of this study was to investigate …