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Full-Text Articles in Medicine and Health Sciences
Identification And Characterization Of Possible Multiple Binding Sites For ((3)H)8-Oh-Dpat In The Hippocampus, Dawna Lea Evans
Identification And Characterization Of Possible Multiple Binding Sites For ((3)H)8-Oh-Dpat In The Hippocampus, Dawna Lea Evans
Masters Theses
No abstract provided.
Fixed-Ratio Size As A Determinant Of The Development Of Tolerance To Morphine, Mark J. Nickel
Fixed-Ratio Size As A Determinant Of The Development Of Tolerance To Morphine, Mark J. Nickel
Masters Theses
The acute and chronic effects of morphine were examined in pigeons exposed to a multiple schedule with fixed ratio 5, 25, and 125 components. Acute exposure to morphine (0.56-10.0 mg/kg) resulted in rate reductions under each component when the dose was 1 mg/kg or higher. With chronic exposure to 5.6 mg/kg, tolerance to the rate-reducing effects of morphine was evident under each fixed ratio component. The development of tolerance was determined to some extent by fixed-ratio size, a result similar to earlier findings with cocaine.