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Jefferson Alumni Bulletin – Volume Xxxix, Number 1, Fall 1989

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XXXIX, Number 1, Fall 1989 State of the College, Page 2 President’s Club honors university benefactors, Page 7 Everest: pain and accomplishment, Page 11 Resurgence of interest in Jefferson history, Page 14 Robert L. Brent, M.D., Ph.D. is honored, Page 18 Class notes, Page 23

Jefferson Alumni Bulletin – Volume Xxxviii, Number 4, Summer 1989

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XXXVIII, Number 4, Summer 1989 Reflections of an outgoing president, Page 2 Commencement 1989, Page 6 164th Alumni Weekend, Page 11 Clinic presentations, Page 17 Class notes, Page 36

Department Of Radiology-Annual Report-July 1, 1988 To June 30, 1989, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1988 to June 30, 1989. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 81 pages.

1989 Commencement For Jefferson Medical College And College Of Graduate Studies

Sidney Kimmel Medical College Commencements

No abstract provided.

1989 Commencement For College Of Allied Health Sciences

Jefferson College of Nursing Commencements

No abstract provided.

Jefferson Alumni Bulletin – Volume Xxxviii, Number 3, Spring 1989

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XXXVIII, Number 3, Spring 1989

The Gibbon Scholars program, Page 2

The Jefferson scene, page 12

Class notes, Page 29

Jefferson Alumni Bulletin – Volume Xxxviii, Number 2, Winter 1989

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XXXVIII, Number 2, Winter 1989

Minerva Medica, Page 2

Jefferson’s program on health policy, Page 12

First woman alumni president, Page 16

Class notes, Page 21

Identification Of Persistent Defects In Insulin Receptor Structure And Function In Capillary Endothelial Cells From Diabetic Rats, Ching Fai Kwok, Barry J. Goldstein, Dirk Muller-Wieland, Tian-Shing Lee, C. Ronald Kahn, George L. King

Department of Medicine Faculty Papers

Insulin actions and receptors were studied in capillary endothelial cells cultured from diabetic BB rats and their nondiabetic colony mates. The endothelial cells from diabetic rats of 2 mo duration had persistent biological and biochemical defects in culture. Compared with normal rats, endothelial cells from diabetic rats grew 44% more slowly. Binding studies of insulin and insulin-like growth factor I (IGF-I) showed that cells from diabetic rats had 50% decrease of insulin receptor binding (nondiabetic: 4.6 +/- 0.7; diabetic: 2.6 +/- 0.4% per milligram protein, P < 0.01), which was caused by a 50% decrease in the number of binding sites per milligram protein, whereas IGF-I binding was not changed. Insulin stimulation of 2-deoxy-glucose uptake and alpha-aminoisobutyric acid uptake were also severely impaired with a 80-90% decrease in maximal stimulation, in parallel with a 62% decrease in insulin-stimulated autophosphorylation (P < 0.05). ¹²⁵I-insulin cross-linking revealed an 140-kD alpha subunit of the insulin receptor similar to …