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Histamine And A Possible Unity Of Autonomous Microcirculatory Dilator Responses: Histamine And Autonomous Dilation, Richard W. Schayer

MCV/Q, Medical College of Virginia Quarterly

In this paper I will try to show how the proposed intrinsic dilator mechanism may, with due allowance for a variety of modifying factors, underlie the dilator phases of reactive hyperemia, post-exercise hyperemia, hyperemia due to local warmth, autoregulation, vasomotion, inflammation, and shock. These ideas are based on histamine studies (Schayer, 1962, 1963, 1966). However since there is much misunderstanding about histamine, and since the theory can be largely developed without need to identify the dilator, this paper will be presented in two parts. First, interpretation of the above phenomena in terms of intrinsic dilator mechanism will be attempted. Second, …