Medicine and Health Sciences Commons^™

Functional Analysis Of Chromatin Remodeler Csb In Parp1/2- Mediated Oxidative Dna Lesion Repair, Rabeya Bilkis

Biomedical Sciences ETDs

The ATP-dependent chromatin remodeler Cockayne syndrome protein B (CSB) is essential for maintaining genome integrity. Mutations in CSB are the primary cause of Cockayne syndrome (CS), a premature aging disorder with severe sun sensitivity and neurodevelopmental symptoms. However, the precise mechanisms underlying the disease etiology remain poorly understood. Given the critical roles of oxidative stress in aging and neurodegenerative disorders, this research sought to determine the mechanisms of CSB’s functions in oxidative DNA damage repair.

In the first aim, we investigated how CSB participates in PARP1/2-mediated oxidative DNA repair. We showed that PARP1 and PARP2 recruit CSB to oxidized chromatin …

Nanofiber-Hydrogel Composite Scaffold Fabrication Methods For Peripheral Nerve Regeneration, Jacob Lee Carter

Theses and Dissertations

Nerve graft conduits (NGCs) are a rapidly advancing field for treating peripheral nerve injuries that aim to guide the growth of regenerating axons across damaged gaps. A more effective NGC can be manufactured by combining the use of nanofibers to act as guidewires within a 3-D hydrogel that imitates the extracellular matrix of nerve tissue. Several methods have been developed to embed aligned nanofibers in an ordered architecture within a hydrogel matrix. The first method involves layer-by-layer additive manufacturing to create NGCs with rows of polycaprolactone (PCL) nanofibers surrounded by a gelatin methacrylate (GelMe) hydrogel in a 3-D structure. A …

More Than Caring: Building A Foundation Of Skills And Competencies To Teach Self-Advocacy In A Female-Dominated Profession, Laura Perri

The Dissertation in Practice at Western University

External patriarchal interventions and market-driven forces have limited professional advancements and autonomy of the female-dominated dental hygiene (DH) profession since its foundation. The DH profession defines itself though caring and advocating for public access to its essential services. However, the lack of voice and autonomy are reported causes of DH practitioner burnout and labour shortages. DH education lacks training and foundational skills for self-advocacy. This Dissertation-in-Practice (DiP) explores the organizational context of a South-Western Ontario DH college (SWO College or the school) and addresses a complex problem of practice (PoP) that recognizes the barriers, both past and present, that kept …

Reducing The Incidence Of Frequent Hospital Readmissions In Veterans Population, Dasari Reddy

Student Scholarly Projects

Practice Problem: Veterans hospital readmission problems are challenging, specifically in the heart failure department, which severely impacts the patient's health, mortality, family, and quality of life. Frequent readmissions increase the usage cost, hospital budget, and loss of time from providers to other veterans, and failure to meet the key guidelines of the Center for Medicare and Medicaid for improvement.

PICOT: The PICOT question that guided this project was, in veterans with heart failure and one or more frequent hospital readmissions discharged in the last 30 days(P), does the appointment of a dedicated discharge nurse practitioner as a coordinator(I), compared to …

Early Detection Of Oral Potentially Malignant Disorders, Xinru Li

Electronic Thesis and Dissertation Repository

Oral potentially malignant disorders (OPMDs) represent a diverse array of conditions with an elevated propensity for progressing into oral squamous cell carcinoma (OSCC). My study aims to enhance the early detection of OPMDs by investigating the expression levels of specific biomarkers, their correlation with disease severity, and the concordance between clinical and pathological diagnoses. Using nanoString gene expression analysis and immunohistochemical (IHC) staining, I identified significantly elevated levels of S100A7, Ki67, and Vimentin in OPMD tissues compared to normal controls, suggesting their potential as biomarkers for early detection and monitoring of disease progression. Conversely, E-cadherin showed reduced expression in OPMDs, …

Feasibility Study Of Mim Auto-Contouring For Head And Neck Patients That Have Dental Artifact Using A Metal Artifact Reduction Scan, Allison C. Munyer

Culminating Experience Projects

Introduction

Accurate contouring of organs at risk (OARs) is essential in the treatment of head and neck cancer, particularly in patients with metal dental artifacts that can obscure critical structures. The ability to precisely define these OARs is crucial for minimizing radiation exposure to healthy tissues and improving patient outcomes. To address the challenges posed by metal artifacts, Metal Artifact Reduction (MAR) technology, including iterative MAR (IMAR) scanning, has been widely adopted in radiation oncology.

Methods

This retrospective study evaluated the impact of IMAR scanning and Medical Image Merge (MIM) auto-contouring software on the accuracy and efficiency of contouring OARs …

A Bundle Of Care For Prevention, Early Recognition, And Treatment Of Hyaluronic Acid Dermal Filler Associated Vascular Occlusion, Genny Sanders

Doctor of Nursing Practice Papers

Background: Hyaluronic acid (HA) dermal fillers, an injectable used for cosmetic use, are gaining popularity, and are expected to continue to do so in the projected future. With the rise in the number of patients seeking these procedures there is a correlated rise is adverse events, including the complication of vascular occlusion. Vascular occlusion has the potential for detrimental outcomes, and clinicians performing these procedures are responsible for educating patients about these risks. As whole, the healthcare community must be prepared.

Purpose: A quality improvement (QI) project was created to help clinicians prepare, prevent, recognize, and treat hyaluronic acid dermal …

Evaluation Of Myogenic Differentiation Potential Of Bmd Ipscs In Vitro And The Effect Of Ubiquitination Inhibitors On Dystrophin Stability In Vivo, Muchen Liu

Dissertations & Theses (Open Access)

Background: Muscular dystrophies are heterogeneous groups of inherited diseases leading to progressive muscular weakness and degeneration. In the case of Becker muscular dystrophy (BMD), non-disrupting mutations of the DMD gene reading frame is the causative defect. By the age of 30s, about 60 to 70% of BMD patients develop cardiomyopathy, which is often lethal. Unfortunately, there is currently no cure for BMD. Meanwhile, improvement of dystrophin stability by repressing polyubiquitination is a promising strategy. The application of human iPSCs in tissue regeneration also serves as a potential therapeutic strategy. This study aims to test the efficacy of selected drugs interfering …

Ot Clinical And Cultural Preparedness Working With Gender Diverse Clients, Arthur Lui

Occupational Therapy Student Capstones

No abstract provided.

Exploring Strategies To Improving Awareness For Preventing Musculoskeletal Disorders Within Dental Students, Tim Zeng

Occupational Therapy Student Capstones

No abstract provided.

Reducing Stress And Improving Mindfulness Practices Among Mental Health Professionals Through Guided Meditation., Liara G. Patton

Doctor of Nursing Practice Papers

Abstract

Background: Chronic exposure to psychological stress places mental health providers in a vulnerable position when coping skills are not learned or available. Mental health providers are at risk for both mental and physical illness due to the empathetic demands of their client’s stressors. The deficit in adequate coping skills can cause provider-client relationships to suffer and create an undesirable work environment.

Setting: This project took place in Somerset, KY, at a mental health company called A New Beginnings Achievement Center (ANBAC). Twenty-six employees work at ANBAC, all of whom are involved in providing mental health services to developmentally delayed …

Contribution Of Dentoalveolar Heights On Facial Heights In Class I And Class Ii Untreated Subjects, Mira Bharat Suvagia

Master's Theses (2009 -)

Objective: This research aims to investigate the impact of dentoalveolar heights on craniofacial growth and the development of Class I and Class II malocclusions in untreated subjects aged 6-18 years. The study seeks to establish relationships between dentoalveolar heights and anterior and posterior facial heights. The findings contribute to understanding the dynamic interplay between dentoalveolar growth, mandibular rotation, and facial height establishment, shedding light on critical aspects of craniofacial development. Materials and Methods: The study draws upon cephalograms from the University of Michigan Growth Study, encompassing untreated Class I and Class II subjects aged 6-18 years. A subsample of 408 …

Orthodontic Load Quantification Leveling A Deep Curve Of Spee With Different Archwire Designs, Ahmed Youssef

Master's Theses (2009 -)

Objective: This study aimed to quantify the effects of different materials, sizes of the continuous archwires in leveling the exaggerated curve of Spee. We used an orthodontic force tester apparatus to measure the forces and moments delivered by the archwires to the brackets attached to the sensors of one quadrant of the arch (from 1st incisor to 2nd molar). The hypothesis is that there is no difference in the load and moments between the incisors when the curve of Spee is leveled with the three different mechanical designs being tested. Methods: An orthodontic force tester (OFT) was used to measure …

Evaluation Of Flooding Disaster Risk Initiatives In Vulnerable Homeless Communities, Nicholas W. O'Clair

Walden Dissertations and Doctoral Studies

Homeless individuals, who have limited resources and lack stable lodging, are particularly vulnerable during disasters, further jeopardizing their already precarious health conditions. By examining the effectiveness of existing preparedness and response strategies on the readiness of homeless individuals during flood events, insights can be gained to enhance emergency operations. The purpose of the study was to investigate the experiences and vulnerabilities of homeless populations in a northeastern U.S. city with the goal of promoting inclusivity and resilience. Research questions involved understanding knowledge of dangers of flooding disasters; disaster preparedness, response, and recovery; and how current public promotion practices of disaster …

Investigating The Role Of Ebf3a In Craniofacial Development, Shujan A. Sharafeldeen

Undergraduate Theses, Capstones, and Recitals

Proper craniofacial development requires many genes. Single-cell RNA sequencing (scRNA-seq) allows us to identify genes expressed in precursor cells for craniofacial structures, but the function of many of these genes in craniofacial development has yet to be characterized. In our scRNA-seq of cranial neural crest cells (NCCs), which are precursor cells for the craniofacial skeleton, we found a gene called early B-cell factor 3 (ebf3a) that may be involved in craniofacial development. In our scRNA-seq data, ebf3a expression is restricted to cranial NCCs of the dorsal and ventral domains of pharyngeal arches 1 and 2. In humans, damaging variants in …

Stress, Geographic And Sociodemographic Factors, And Oral Health Outcomes In Adolescents And Young Adults, Naima Abouseta

Electronic Thesis and Dissertation Repository

Oral health disparities are influenced by socioeconomic and demographic factors. Recent research suggests that stressors can contribute to these disparities. Adolescents and young adults are particularly vulnerable to these stressors, which can affect hypothalamic-pituitary-adrenal (HPA) axis reactivity. This thesis aimed to enhance understanding of the relationships among stress, geographic and sociodemographic factors, and oral health outcomes in adolescents and young adults. Additionally, salivary levels of mRNA encoding the glucocorticoid receptor (GR) were assessed and their relationship to stress and oral health outcomes investigated.

In the first study, the association between neighborhood-level socioeconomic status and dental care outcomes was explored in …

A Comparison Of Temporary Threshold Shifts In Dentists, Hygienists, And Dental Assistants, Sabina E. Ciaccio

Dissertations, Theses, and Capstone Projects

Objective: The purpose of this study is to compare the temporary threshold shifts (TTS) in dentists, hygienists, and dental assistants. The specific aim of this study is to compare the differences in temporary shifts caused by the different dental equipment and the proximity to the equipment. The current literature does not compare the change in hearing thresholds of dental personnel.

Methods: Dentists, dental assistants, and hygienists from Hermann Dental Associates will be given a case history form to determine inclusion status for this study. Exclusion criteria will include known hearing loss and significant noise exposure the day prior. …

Toolkit For Users Of Over-The-Counter Hearing Aids, Sabrina Malasarte

Dissertations, Theses, and Capstone Projects

Untreated hearing loss oftentimes has significant adverse effects on the quality of life of older adults. The associations include, but are not limited to loneliness, isolation, anxiety, and a decrease in cognitive function. Hearing aids significantly improve audibility, social interactions, and decrease feelings of loneliness or isolation. However, despite technological advances, and evidence of positive outcomes associated with hearing aid use, uptake and continued use of hearing aids remain low. Accessibility and affordability are considered barriers to uptake. Purchasing a prescription hearing aid from an audiologist is the traditional approach to receiving an amplification device, but the advent of over …

Best Practices For Healthcare Providers When Communicating With Individuals With Hearing Loss: A Systematic Review, Ashley Mccaig

Dissertations, Theses, and Capstone Projects

Objectives: The purpose of this study is to conduct a systematic review of the literature to gather information about strategies to use when communicating with people with hearing loss, specifically in healthcare settings or environments where face masks are frequently used. The compiled literature was used to establish the best practices for healthcare providers to use when communicating with their patients with hearing loss, especially when utilizing face masks.

Methods: A comprehensive search of the literature was conducted using the Google Scholar, PubMed, and MEDLINE Complete databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was used to …

Keep Our Children Smiling: Fluoride Varnish Education In The Pediatric Primary Care Setting, Isabella Mortola

Doctor of Nursing Practice Final Manuscripts

Background: Dental caries is the most common chronic childhood disease. In early childhood, it is associated with many negative factors such as pain, loss of teeth, and impaired growth. Fluoride varnish (FV) is a protective resin coating treatment that is reimbursable by most insurances and is recommended by the American Academy of Pediatrics (AAP), United States Preventative Services Task Force (USPSTF), and the American Dental Association (ADA) due to its high efficacy in preventing dental caries. FV is a low-cost treatment that can be easily applied in 1-2 minutes during a well-child visit in the primary care setting, where children …

Implementing An Abnormal Involuntary Movement Scale At An Outpatient Mental Health Clinic, Amanda Ghamsari

Doctor of Nursing Practice Final Manuscripts

Background: Movement disorders caused from psychotropic medications affect an estimated 500,000 people in the United States. These disorders bring an added cost for treatment to the patient, cause emotional distress, and may hinder daily life. Overall health and additional medication costs were increased for these patients by $25,879 per patient per year compared to patients without a movement disorder.

Purpose of Project: To address the issue, the team of mental health providers at an outpatient clinic assess their mental health patients at start of care and at follow up visits utilizing the Abnormal Involuntary Movement Scale. With the goal of …

Experience Of Community Physicians Who Provide Medical Assistance In Dying: A Qualitative Analysis, Rimpy Cheema

Electronic Thesis and Dissertation Repository

Aims: Since decriminalization in 2016, medical assistance in dying (MAiD) has transformed the landscape of end-of-life care in Canada. This study explored the experiences of community family physicians who provide MAiD.

Methods: Using a qualitative study design and phenomenological approach, semi-structured interviews were conducted of twelve physician providers in Southwestern Ontario. The transcripts were coded and inductively analyzed for overarching themes.

Findings: At the individual level, providers felt a profound sense of purpose. At the local level, participants reflected on the practical challenges encountered. At the system level, participants described the critical role of organizational support structures and the effects …

Utilizing Flow Arts Movement As An Expressive Arts Therapy Tool To Treat Trauma: A Literature Review And Autoethnography, Shannon Mcgrail

Expressive Therapies Capstone Theses

This expressive arts-based autoethnography research explores the effectiveness of using flow arts movement as a tool of expressive arts therapy to treat symptoms of trauma for individuals who experienced a traumatic event in their lifetime. While research on the use of flow arts movement to treat mental illness is in its early stage, much can be drawn from the literature on expressive arts therapy and dance/movement therapy research with a range of populations addressing trauma. Through exploration of trauma through neuroscience, mind, body, and integrated mindfulness through flow, this work aims to bring an understanding of using intermodal expressive arts …

Oral Health Education And Dental Care Access Of Families Of Children With Down Syndrome In New Mexico, Alayna Marissa Holcomb

Dental Hygiene ETDs

ABSTRACT

Purpose: The purpose of this study was to assess the oral health education and dental care access of families of children with Down syndrome in New Mexico.

Methods: The data were gathered from a survey available to members of the Rio Grande Down Syndrome Network for 14 days containing 13 questions.

Results: The most reported age range for the individuals in care were 0-14 years at 41.6%. Most individuals with Down syndrome receive dental services every six months (62.5%) at a regular dental office (54.2%). Caregivers reported the individuals are taking 1-2 prescription medications (54.2%) and not aware of …

Proposals To Address Health Disparities In Occupational Therapy, Madison Michelle Cotten

Honors Theses

Health disparities, “preventable differences in the burden of disease, injury, violence, or opportunities to achieve optimal health,” are infamous for their effects within both general healthcare and occupational therapy settings (Centers for Disease Control and Prevention [CDC], 2008). Though existing literature establishes a need for the widespread adoption of anti-discrimination measures, specific recommendations for occupational therapy schools remain limited. This project aims to remedy this gap in knowledge by serving as an initial overview of healthcare disparities within occupational therapy and by addressing the potential value of incorporating diversity courses into the curriculum of occupational therapy schools. Through the presentation …

Examining The Nexus Of Food Insecurity And Oral Health, Abigayle Talbot

Honors Theses

This research paper delves into the relationship between oral health and nutrition status among individuals with food insecurity. As both oral health and nutritional well-being play pivotal roles in overall health, understanding their interplay in the context of food insecurity becomes important. This study investigated how inadequate access to food resources, a characteristic of food insecurity, can impact oral health, leading to a spectrum of dental issues. The study explores the impact of compromised oral health on dietary habits, potentially resulting in nutritional deficiencies or malnutrition. By examining the potential pathways through which these factors influence each other, the study …

The Influence Of Preventive Dental Care And Its Role On The Patient-Provider Relationship, Maria Figueroa

Senior Theses and Projects

No abstract provided.

Childhood Food Insecurity As It Relates To Adult Intuitive Eating Patterns, Lily Langley

Honors Theses

Many American families struggle with food insecurity and do not have the economic capabilities to obtain a sufficient quantity of nutritious food. Childhood food insecurity is associated with negative health effects and altered relationships with food as an adult. Intuitive eating, a non-diet framework that emphasizes mindful eating, may attenuate these effects. It includes unconditional permission to eat, eating for physical rather than emotional reasons, reliance on hunger and satiety cues, and body-food choice congruence. Previous research has not examined whether childhood food insecurity can affect one’s ability to eat intuitively as an adult. The goal of this study was …

Major Injuries Sustained In Towable Watersports, Elijah J. Klein

Honors Thesis

Towable watersports are activities where a participant is being pulled by a motorized watercraft while wearing or holding onto a floating device. Watersports come with many known risks such as drowning, whiplash, and fatigue; however, other injuries are often overlooked or misunderstood. With this thesis, I aimed to explore injury records pertaining to towable watersports and attempted to identify prevalent injury trends in wakeboarding, waterskiing, and water tubing. Using the National Electronic Injury Survey System (NEISS), a public database with yearly injury records, I compiled information related to the relevant sports from 2013 to 2022. Included with the data is …

Identifying Srnas Individual Learning Preferences Utilizing The Vark Learning Inventory Tool, James Eads

Doctor of Nursing Practice Projects

Abstract

All graduates of a doctoral anesthesiology program are required to successfully pass the National Certifying Exam (NCE). Since 2011, the national average passage rate has decreased from 89.1% to 84.1% in 2021 (NBCRNA, 2023). Yamaguchi’s 2022 study revealed that students are positively impacted academically when they implement individual learning preferences. The purpose of this project was to identify individual learning preferences for students enrolled in the U.S. Army Nurse Anesthesiology program. The hypothesis was that students who recognize their preferred learning and incorporate preferred learning techniques would result in an increased percentage of passage rate scores for the NCE. …