Medicine and Health Sciences Commons^™

Optimizing Tumor Xenograft Experiments Using Bayesian Linear And Nonlinear Mixed Modelling And Reinforcement Learning, Mary Lena Bleile

Statistical Science Theses and Dissertations

Tumor xenograft experiments are a popular tool of cancer biology research. In a typical such experiment, one implants a set of animals with an aliquot of the human tumor of interest, applies various treatments of interest, and observes the subsequent response. Efficient analysis of the data from these experiments is therefore of utmost importance. This dissertation proposes three methods for optimizing cancer treatment and data analysis in the tumor xenograft context. The first of these is applicable to tumor xenograft experiments in general, and the second two seek to optimize the combination of radiotherapy with immunotherapy in the tumor xenograft …

Uncovering The Role Of Fat-Infiltrated Axillary Lymph Nodes In Obesity-Related Diseases With Statistical And Machine Learning Analyses, Qingyuan Song

Dartmouth College Ph.D Dissertations

The link between obesity and pathogenesis is a complex and multifaceted area of research that is yet to be fully understood. Ample evidence exists to demonstrate the direct relationship between excessive internal fat and various health conditions such as cancer, and metabolic and cardiovascular diseases. The infiltration of ectopic fat into axillary lymph nodes, observable on breast cancer screening images, has been shown to be correlated with body mass index (BMI) in women undergoing screening. This study aimed to explore the relationship between fat-infiltrated axillary lymph nodes (FIN) and obesity-related diseases, with the goal of evaluating the clinical value of …

The Efficacy Of The Covid-19 Vaccine In Mississippi, Ilyse Miriam Levy

Honors Theses

The Efficacy of The COVID-19 Vaccine in Mississippi

(Under the direction of Dr. Xin Dang)

By tracking and analyzing fifty-three weeks of COVID-19 data, this thesis analyzes the efficacy of the COVID-19 vaccine within the State of Mississippi. Over the course of these fifty-three weeks, I have also been able to calculate the confidence intervals for vaccination efficacy and the risk reduction due to vaccination by using data regarding the correlations between deaths and vaccination status, provided to me by the Mississippi Office of Epidemiology. My analysis demonstrates that the COVID-19 vaccine is effective not only in Mississippi but also …

Developing A Diagnostic Tool Of A Community’S Health, Ruth Kurtycz

Dissertations

Where we live can affect nearly every aspect of our lives, including how long those lives will be. Previous studies have demonstrated large health disparities between communities in the United States; since the health of a community can significantly impact its residents, evaluating and predicting community health is of interest to many people. Currently the Federal government collects and publishes data on community-level demographics, housing, crime rates, and disease. State-level and non-governmental agencies track and share community housing prices, school performance, neighborhood safety, and other characteristics. In short, there is a wealth of information but the work being done around …

Datashare Monterey County Website, Audra Ketchem

Capstone Projects and Master's Theses

The DatashareMontereyCounty website was created by combining Conduent technology and knowledgeable staff from the Monterey County Public Health Department. This project attempted to solve the disengagement between many people in Monterey County and health interventions/prevention initiatives set in place by the health department. Two contributing factors related to community disengagement were that residents were not always aware of works the health department was attempting to promote and the complexity of health data (statistics). The main focus of the project demonstrates how understanding health information may or may not impact decision making. When concepts are difficult to understand this can deter …

The Reproducibility Crisis In Scientific Research, Sarah Eline

Senior Honors Projects, 2010-2019

Following the push for evidence based practice, came a huge proliferation of research journals and journal articles. With this increase in quantity came an increased concern about the quality of these articles being published, which led to a multifield investigation regarding the reproducibility of scientific research. With studies in the fields of psychology and biomedicine only reaching approximately a 30% reproducibility rate, a conversation has been sparked that spans across every field of research. Upon further investigation, various causes for this reproducibility crisis have surfaced which include, lack of data sharing/ transparency, statistical errors, funding corruption, and the culture surrounding …

Reporting Number Needed To Treat In Clinical Trials Published In Physical Therapy Specific Literature 1989 - 2018, Susan Ann Talley

Wayne State University Dissertations

Evidence-based practice requires physical therapists to make clinical decisions about the best intervention to use when providing services to patients/clients. Although null hypothesis significance testing (NHST) is frequently used to interpret the outcome of a clinical trial investigating the comparative effectiveness of an intervention, statistical significance does not directly translate into clinical importance. Number needed to treat (NNT) is a measure of effect size (ES) that may be particularly useful when translating the results from clinical trials to PT clinical practice. The purpose of this study was to conduct a bibliometric content analysis of the methods of reporting research results …

Strong Side, Weak Side: Goal Generating Tactics In Ncaa Men's Water Polo, Joey Gullikson

University of the Pacific Theses and Dissertations

In the game of water polo, it is generally accepted that the shooting position of the offensive player and the tactic employed are both important in generating goals. Despite their importance, little is known about the relationship between shooting position and offensive tactics and their impact on the probability of goal scoring. In this research, a sequence of hierarchical mixed logistic regression models is applied to a unique data set from 2016 and 2017 NCAA men’s water polo seasons to analyze the relationship between goal generating tactics and different shooting positions. The primary result reveals that the closer a player …

Consultation Experience In Public Health, Zimu Li

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Nowadays, students safe in violence area is becoming to a huge problems, from the survey- National Youth Risk Behavior Survey we find that the sexual and dating violence rate is increasing during the past few years.For the willing that we try to reduce the risk of dating and sexual violence, we are going to build some programs and publish them to the society especially the schools to protect our teenagers. As we know that the period for students from high school to the university is a very important time to build their right social norms, we start a program called …

Bayesian Analytical Approaches For Metabolomics : A Novel Method For Molecular Structure-Informed Metabolite Interaction Modeling, A Novel Diagnostic Model For Differentiating Myocardial Infarction Type, And Approaches For Compound Identification Given Mass Spectrometry Data., Patrick J. Trainor

Electronic Theses and Dissertations

Metabolomics, the study of small molecules in biological systems, has enjoyed great success in enabling researchers to examine disease-associated metabolic dysregulation and has been utilized for the discovery biomarkers of disease and phenotypic states. In spite of recent technological advances in the analytical platforms utilized in metabolomics and the proliferation of tools for the analysis of metabolomics data, significant challenges in metabolomics data analyses remain. In this dissertation, we present three of these challenges and Bayesian methodological solutions for each. In the first part we develop a new methodology to serve a basis for making higher order inferences in metabolomics, …

Association Tests For Genetic Effect And Its Interaction With Environmental Factors, Zhengyang Zhou

Statistical Science Theses and Dissertations

My research is in the area of statistical genetics, and it contains three projects: (1) Differentiating the Cochran-Armitage (CA) trend test and Pearson’s chi-square test: location and dispersion; (2) Decomposing Pearson’s chi-square test: a linear regression and its departure from linearity; (3) Testing nonlinear gene-environment (GxE) interaction through varying coefficient and linear mixed models.

(1) In genetic case-control association studies, a standard practice is to perform the CA trend test with 1 degree-of-freedom (df) under the assumption of an additive model. However, when the true genetic model is recessive or near recessive, it is outperformed by Pearson’s chi-square test with …

An Exploratory Statistical Method For Finding Interactions In A Large Dataset With An Application Toward Periodontal Diseases, Joshua Lambert

Theses and Dissertations--Epidemiology and Biostatistics

It is estimated that Periodontal Diseases effects up to 90% of the adult population. Given the complexity of the host environment, many factors contribute to expression of the disease. Age, Gender, Socioeconomic Status, Smoking Status, and Race/Ethnicity are all known risk factors, as well as a handful of known comorbidities. Certain vitamins and minerals have been shown to be protective for the disease, while some toxins and chemicals have been associated with an increased prevalence. The role of toxins, chemicals, vitamins, and minerals in relation to disease is believed to be complex and potentially modified by known risk factors. A …

Geographic Disparities Associated With Stroke And Myocardial Infarction In East Tennessee, Ashley Pedigo Golden

Doctoral Dissertations

Stroke and myocardial infarction (MI) are serious conditions whose burdens vary by socio-demographic and geographic factors. Although several studies have investigated and identified disparities in burdens of these conditions at the county and state levels, little is known regarding their geographic epidemiology at the neighborhood level. Both conditions require emergency treatments and therefore timely geographic accessibility to appropriate care is critical. Investigation of disparities in geographic accessibility to stroke and MI care and the role of Emergency Medical Services (EMS) in reducing treatment delays are vital in improving health outcomes. Therefore, the objectives of this work were to: (i) classify …

Accident Experience Of Commonwealth Government Employees In Western Australia : 1 June 1993 To 2 December 1995, David R. Wright

Theses: Doctorates and Masters

This quantitative study documents, analyses and discusses the accident experience of Commonwealth employees in Western Australia from 1 July 1993 to 2 December 1995 as recorded on 1663 accident report forms. The research addresses the problem of lack of knowledge of accidents in the Commonwealth sector of the Western Australian work force. Its purpose is to identify possible areas of health and safety improvement and highlight where accident frequency may be reduced. Risk management is adopted as a conceptual framework to explore categories of accident related data, including month of year, time of day, day of the week of accidents, …

A Study Of The Height And Weight Of Chinese School Children In Some Northern Californian Cities, Lillian Wai-Chuen Chow

University of the Pacific Theses and Dissertations

In any study of physical fitness or of nutritional well-being of a group of people, a knowledge of the normal height and weight of that group serves as a valuable guide. Thus, Height-Weight-Age tables have been prepared and are being used in schools, gymnasiums, camps, etc., as a gauge of physical development in children. However, for the group of Chinese school children in the United States very little work has been done to determine the normal height range and weight at the different ages and the normal height-weight-age relationships.

Because of the lack of data on the normal weights and …