Medicine and Health Sciences Commons^™

Targeting Metabolic Alterations Associated With Smooth Muscle Α-Actin Pathogenic Variant Attenuates Moyamoya-Like Cerebrovascular Disease, Anita Kaw

Dissertations & Theses (Open Access)

Heterozygous pathogenic variants in ACTA2, encoding smooth muscle α-actin (α-SMA), predispose to thoracic aortic aneurysms and dissections. De novo missense variants disrupting ACTA2 arginine 179 (p.Arg179) cause a multisystemic disease termed smooth muscle dysfunction syndrome (SMDS), which is characterized by early onset thoracic aortic disease and moyamoya disease-like (MMD) cerebrovascular disease. The MMD-like cerebrovascular disease in SMDS patients is marked by bilateral steno-occlusive lesions in the distal internal carotid arteries (ICAs) and their branches. To study the molecular mechanisms that underlie the ACTA2 p.Arg179 variants, a smooth muscle-specific Cre-lox knock-in mouse model of the heterozygous Acta2 R179C variant, termed …

An Examination Of Pain Education Of Medical Students In Australia And New Zealand, Elspeth Shipton

Theses

Background: Unrelieved pain is a significant public health challenge in Australia and New Zealand. Medical practitioners play an essential role in the management of acute, cancer and chronic non-cancer pain.

Aim: This thesis aimed to examine the delivery of pain education at medical schools in Australia and New Zealand, and to determine how effectively it equips medical students with pain medicine competencies required for internship.

Methods: An explanatory sequential mixed methods approach was used. Quantitative studies focused on gathering information regarding the pain-related content of medical curricula of all medical schools; and on testing pain medicine competencies of final-year medical …

A Heuristic Inquiry: The Narrative Of A Beginning Dance/Movement Therapist's Professional Identity Development, Danielle Parmacek

Creative Arts Therapies Theses

There are theories, models, and theses that explain what generally happens as people move through the identified phases of counselor and professional identity development. However, there is little literature that illustrates how this growth actually happens for clinicians. The purpose of this heuristic self-study was to identify and gain a deeper understanding of the narrative of how my clinical experiences have influenced my professional identity as a dance/movement therapist. This study utilized the six phases of heuristic inquiry as a structure to guide this discovery. My personal recollections of three identified cases were used as data, which was then analyzed …

Interpreting, Stephanie Jo Kent

Doctoral Dissertations

What do community interpreting for the Deaf in western societies, conference interpreting for the European Parliament, and language brokering in international management have in common? Academic research and professional training have historically emphasized the linguistic and cognitive challenges of interpreting, neglecting or ignoring the social aspects that structure communication. All forms of interpreting are inherently social; they involve relationships among at least three people and two languages. The contexts explored here, American Sign Language/English interpreting and spoken language interpreting within the European Parliament, show that simultaneous interpreting involves attitudes, norms and values about intercultural communication that overemphasize information and discount …

An Examination Of The Combined Influences Of Maternal Cognitions, Affect, And Behavior On Child Outcomes: A Model Comparison Approach, Elizabeth A. Heideman

Dissertations (1934 -)

The primary goal of this study was to better understand the combined influence of maternal affect, cognitions and behavior on child internalizing and externalizing behavior. Specifically, mothers and children completed a series of measures designed to assess parenting stress, parenting efficacy, parenting behavior, and child internalizing and externalizing behavior. Participants were 115 mothers and their school-aged children who participated in an outpatient neuropsychological evaluation. Results suggest that child reported maternal warmth and control were important in influencing the development of internalizing behavior in children. Additionally, maternal parenting stress, warmth and control were found to be important influences in the development …