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Full-Text Articles in Medicine and Health Sciences
Various Synthetic Pathways Towards Efavirenz And Its Analogs; The Replacement Of The Side Chain, Elizabeth S. Bautista
Various Synthetic Pathways Towards Efavirenz And Its Analogs; The Replacement Of The Side Chain, Elizabeth S. Bautista
Selected Honors Theses
Cyclopropyl acetylene (CA) is a key intermediate in the synthesis of the human immunodeficiency virus (HIV) reverse transcriptase inhibitor, Efavirenz (EFV), an antiviral drug used to treat HIV. CA is an expensive raw material, difficult to obtain, and employed in the preparation of medications to combat acquired immunodeficiency syndrome (AIDS). It was found that the structure could be synthesized by the utilization of PCl5; however, this resulted in unwanted ring opening products. To address this issue, a one pot synthesis was developed using Ph3PCl2 as a mild chlorinating agent. In addition, a new analog has been proposed substituting the cyclopropyl …
Hiv Stalks Bodies Like Mine: An Autoethnography Of Self-Disclosure, Stigmatized Identity, And (In)Visibility In Queer Lived Experience, Steven Ryder
USF Tampa Graduate Theses and Dissertations
This dissertation examines self-disclosure of Human Immunodeficiency Virus (HIV) status within the context of communication between long-standing friends. For the purposes of my study, I define this type of friendship as those who have known me for at least two years and with whom I communicate regularly. These are friends who tend to know a variety of personal details about me, ranging from superficial to private and trivial to essential. I use autoethnography to ground the study in my lived experience. By doing so, I present intimate accounts of my communication with others across my lifespan to function as background …