Medicine and Health Sciences Commons^™

The Development Of A Brain Penetrating Erythropoietin For The Treatment Of Alzheimer’S Disease, Joshua Yang

KGI Theses and Dissertations

The development of a neurotherapeutic for the treatment of Alzheimer’s Disease (AD) is challenging due to limited endpoint efficacy. Erythropoietin (EPO), a hematopoietic neurotrophin, is a potential therapeutic for AD but has limited blood-brain barrier (BBB) permeability. A chimeric fusion protein of EPO bound to the transferrin receptor monoclonal antibody (cTfRMAb) can act as a molecular trojan horse for brain drug delivery, shuttling EPO into the brain via the transvascular route. However, cTfRMAbs have Fc-effector function adverse effects, and removal of the Fc N-linked glycosylation site by substituting Asn with Gly (cTfRMAb-N292G-EPO) reduces this Fc effector function. Hence, developing this …

Elucidating The Role Of O-Glcnacylation And Gsk3b In Alzheimer's Disease, Emily Valencia

Selected Honors Theses

Alzheimer’s disease (AD) is one of the most common types of neurodegenerative disease. There are currently no treatment methods for AD, but there are treatments for some of the symptoms. Aberrant levels of both O-GlcNAcylation and GSK3ß have been found in patients with AD. Studies have suggested that there is a relationship between the level of O-GlcNAcylation and the phosphorylation of GSK3ß. In order to discover new treatment methods, the phosphorylation of GSK3ß should be explored. This study uses a western blot analysis to quantify the ratio of p-GSK3ß:GSK3ß between the experimental group (higher levels of O-GlcNAcylation) and a control …

Small Heat Shock Protein 22 Preserves Neuronal Function In A Murine Model Of Tauopathy, Santiago Rodriguez Ospina

USF Tampa Graduate Theses and Dissertations

Proteinopathies is a family of diseases associated with the pathological aggregation of protein. There are a multitude of proteinopathies, like tauopathy and synucleinopathy that contribute to neurodegenerative diseases like Alzheimer’s disease (AD), Creutzfeldt-Jakob, Pick’s disease, Frontotemporal dementia, and Parkinson’s disease (PD). Currently, one focus of research in the field is mitigating aggregation-prone proteins contributing to disease state. One method of targeting aggregation is the use of chaperones. Chaperones are molecular machinery that help maintain homeostasis in the cells, through various roles and mechanisms, one of those methods is to regulate protein aggregation. Chaperones can achieve this by affecting protein-protein interactions, …

Developing A Telehealth Protocol For Cognitive Testing, Victoria M. Greenough Dnpc, Rn

College of Nursing and Health Sciences Doctor of Nursing Practice (DNP) Project Publications

BACKGROUND:

When the Coronavirus pandemic reached the United States in March 2020, many healthcare services moved to telehealth delivery. For patients with cognitive impairment, the Mini Mental Status Examination (MMSE) moved from traditional face-to-face assessment to telehealth testing in one Vermont specialty clinic. The aim of this DNP project was to provide quality assurance of this method prior to implementation of the MMSE Version 2 that would follow a similar telehealth protocol.

METHODS:

To assess MMSE quality administered via telehealth, a retrospective chart review of patients (n=30) seen between April 2020 and September 2021 was completed. Linear regression calculated the …

Alzheimer's Disease: Risk And Protective Factors To Improve Detection And Prevention, Darryl Clay Nevels

Walden Dissertations and Doctoral Studies

Alzheimer’s disease (AD) is a growing epidemic and is the sixth-leading cause of death in the United States. Individuals with AD often have comorbidities due to the aging process. There is a lack of research on comorbidities as associated risk factors for AD. The leading hypothesis indicates that cardiovascular health issues, environmental exposure, social isolation, and amyloid-beta plaques influence cognitive health and are associated with AD. This study, guided by Finch and Kulminski’s AD exposome, is a caveat to explore a patient’s physical history of cardiovascular health, modifiable behavior, social isolation, and an AD diagnosis. Participants provided health information collected …

Examining The Utility Of Auditory Processing Tests In Clinical Neuropsychology, Behnaz Sarlak

Walden Dissertations and Doctoral Studies

Memory loss has been a concern in patients with neurodegenerative disease, as it can cause cognitive problems such as speech and language issues. Clinicians need to use reliable, assessable, noninvasive, repeatable, and inexpensive tools to diagnose memory impairment. There is a gap in the literature on whether specific cognitive tests provide valid, reliable, cost and time-effective methods for screening for dementia. The purpose of this quantitative correlational study was to examine if the Seashore, the Speech-Sound Perception Test, the SCAN-A test, Logical Memory, Verbal Paired Associates, and Digit Span Test can predict whether an individual has been diagnosed with Alzheimer’s …

The Role Of Protein Translation And Degradation In Aging And Alzheimer Disease Pathogenesis, Harper S. Kim

All ETDs from UAB

Protein translation (PT) is an essential cellular process playing crucial roles in growth and development. PT precipitously declines with age in multiple animal species, including humans. It has been implicitly assumed that elevated PT at young ages is beneficial to health while PT ends up dropping as a passive byproduct of aging. However, whether this holds true and how dynamic fluctuations in PT over time impact aging remain unknown. In Drosophila, we show that a transient PT spike in early-adulthood drives aging by triggering dysfunction in protein homeostasis (proteostasis) at old ages. We propose the early-adulthood spike in PT to …

Uncovering The Role Of Apoe4 On Alzheimer’S Disease-Related Neuroinflammation, Courtney Marie Kloske

Theses and Dissertations--Physiology

Alzheimer’s disease (AD) is the most common neurodegenerative disease and is characterized by two hallmark pathologies: amyloid-beta plaques (Ab plaques) and hyperphosphorylated, aggregated tau tangles. These pathologies are typically accompanied by the presence of neuroinflammation which is primarily mediated by microglia. Interestingly, several genetic risk factors that increase the risk of AD also have direct impacts on neuroinflammation. Of interest, Apolipoprotein E (ApoE) is the largest genetic risk factor for AD. ApoE has three isoforms- E4 confers an increased risk for AD, E3 is considered the “control” phenotype, and E2 is protective against AD. E4 plays a role in virtually …

Alzheimer Disease Special Care Units And Nursing Homes' Organizational Performance, Giovanna Pilonieta Ortiz

All ETDs from UAB

Alzheimer’s disease special care units (AD SCUs) have been adopted to provide specialized care for people with dementia in nursing homes. However, the effects of environmental and organizational factors on AD SCUs adoption by nursing homes and their influence on nursing homes' organizational performance remains unclear. Guided by Resource Dependence Theory, Donabedian’s Structure-Process-Outcome (SPO) framework and the Resource-Based View of Firms perspective, the purpose of the three papers included in this dissertation was to provide empirical evidence of the contextual and organizational factors that influence AD SCUs adoption among nursing homes and how the adoption of AD SCUs impact nursing …