Medicine and Health Sciences Commons^™

The Effects Of Pre- And Postnatal Administration Of Propionic Acid And Lipopolysaccharide On The Behaviour Of Adolescent Male And Female Rats, Kelly A. Foley

Electronic Thesis and Dissertation Repository

The gut microbiome plays an important role in immune functioning and neurodevelopment. Altered microbiome composition, leading to short chain fatty acid, and/or immune system dysfunction has been observed in children with autism spectrum disorders (ASD). This thesis describes the developmental influence of prenatal exposure to propionic acid (PPA), a metabolic fermentation product of enteric bacteria, or prenatal exposure to lipopolysaccharide (LPS), a bacterial mimetic and product of enteric bacteria, on a range of behaviours in male and female neonatal, adolescent and adult rats. Study one evaluated the effects of prenatal PPA and LPS, and postnatal PPA, on developmental milestones in …

The Effect Of Using Low Dose Exposure To A Humanoid Robot To Elicit Social Engagement Behaviors In Children With Autism Interacting With A Familiar Adult, Cambrie Nicole Roueche

Theses and Dissertations

This study examined the effects of low dose exposure to a humanoid robot on the social engagement skills of four children with autism during select activities with a familiar adult. Participants included two males and two females who ranged in age from four to nine at the commencement of the study. The current study was part of a larger investigation focused on the effect of exposure to a robot on social engagement with a variety of social partners and situations. Children participated in variable multiple baseline sessions followed by a varied number of sessions of traditional treatment. After traditional treatment, …

The Effects Of Intervention Involving A Robot On Compliance Of Four Children With Autism To Requests Produced By Their Mothers, Holly Jeanne Nelson

Theses and Dissertations

The current study presents the use of a humanoid robot to facilitate compliant behaviors to two types of directives in four children with autism. The children participated in a three-month intervention program that incorporated core components of the SCERTS model in order to facilitate social communication (Prizant, Wetherby, Rubin, & Laurent, 2003). Treatment sessions were comprised of 40 minutes of traditional treatment and 10 minutes of interaction with a humanoid robot. Pre- and post-intervention assessment were conducted, each involving a 5 minute interaction with the child's mother, in which they were presented with directives in the form of physical manipulation …

Evaluation Of Motor Speech And Intervention Planning For Children With Autism, Marcil J. Boucher

Open Access Dissertations

Autism affects 1 in 88 children (Center for Disease Control, 2009), approximately 50% of whom will not develop speech (Seal & Bonvillian, 1997). Some researchers hypothesize that these difficulties in developing oral speech reflect underlying motor speech deficits (Prizant, 1996; Seal & Bonvillian, 1997; Szypulski, 2003; Andrianopoulos, Boucher, Velleman & colleagues 2007-2010). This investigation sought to identify the presence or absence of specific motor speech markers in ASD through an innovative best-practice protocol for assessing the speech, prosody, and voice quality of individuals with ASD.

The study focused on apraxic-like motor planning/programming features and dysarthric-like motor execution features in imitated, …

Theory Of Mind And The Ability To Make Emotional Inferences Among Children With High-Functioning Autism Spectrum Disorders, Abigail Leibovitch

Open Access Dissertations

Perspective-taking skills are central to the successful navigation of social situations. Children need perspective-taking skills to help them correctly interpret different cues and accurately assess social situations so they can determine how to best respond. Children with Autism Spectrum Disorders (ASD) exhibit marked impairments in this area. In order to develop successful social skills interventions for this population, it is critical that we have a strong understanding of the nature of their deficits. While there is robust evidence that children with ASD experience difficulty making inferences about the beliefs of others, research on their ability to infer emotions has had …

Comparison Of The Pervasive Developmental Disorders Screening Test And Modified Checklist For Autism In Toddlers: Which Is The Better Predictor Of Autism In Toddlers?, Vanessa Marie Fessenden

UNLV Theses, Dissertations, Professional Papers, and Capstones

Early intervention for children with autism spectrum disorders (ASD) has significant impact on children and families. Early intervention optimizes long-term diagnosis for children with ASD. Unfortunately, many children with ASD are not diagnosed until after age three and often receive services from a local school district rather than through early intervention services. However, many of the symptoms of ASD can be hard to identify because symptoms during infancy may be more difficult to detect or may present differently than manifestations of the symptoms at older ages. Despite the difficulty in identifying symptoms of ASD in young children, there are certain …

Between Wind And Water: Experiences Of Mothers Of Adolescents With Autism During The Post-High School Transition, Devon R. Casey

Honors Theses and Capstones

Research Question: How do mothers of adolescents with autism experience and prepare for their child's post- high school transition?

Magnetic Resonance Imaging Of Brain Tissue Abnormalities: Transverse Relaxation Time In Autism And Tourette Syndrome And Development Of A Novel Whole-Brain Myelin Mapping Technique, Yann Gagnon

Electronic Thesis and Dissertation Repository

The transverse relaxation time (T2) is a fundamental parameter of magnetic resonance imaging sensitive to tissue microstructure and water content, thus offering a non-invasive approach to evaluate abnormalities of brain tissue in-vivo. Prevailing hypotheses of two childhood psychiatric disorders were tested using quantitative T2 imaging and automated region of interest (ROI) analyses. In autism, the under-connectivity theory, which proposes aberrant connectivity within white matter (WM) was assessed, finding T2 to be eleveted in the frontal and parietal lobes, while dividing whole brain data into neurodevelopmentally relevant WM ROIs found increased T2 in bridging and radiate WM. In Tourette syndrome, tissue …

Intervention With Children With Autism: The Effect Of Using A Robot On Participation In Reciprocal Play, Shereen Ririe

Theses and Dissertations

The current study was part of a larger work investigating the effects of intervention incorporating a robot on the social engagement behaviors of children with autism. The larger study implemented a single-subject, multiple-baseline research design in which four children with autism participated in baseline sessions, traditional intervention, intervention including a robot, and follow-up sessions. The current study focused on the participant's responses to directives from the clinician and the parent during collaborative activities that included the robot. Children's responses were analyzed to determine if they responded to directives without assistance, responded with hand-over-hand assistance, or did not comply. Sessions were …

The Effect Of A Robot On Children With Severe Autism During A Song Activity, Michelle Nelson

Theses and Dissertations

This study is a small portion of a larger work examining the effects of low dosage robot use in interactive and social engagement therapy for children with autism. The purpose of this study was to investigate the participation of the subjects during song activities. Four children were used as participants, each receiving a total of 20 play-based treatment sessions targeting engagement and social interaction. The clinician incorporated the robot into these treatment sessions for 10 minute long segments within a 50 minute session. The current study analyzed these 10 minute segments with the robot, coding turn-taking behaviors. Results indicated that, …

Uncovering The Molecular Pathways Of Mbd5 In Neurodevelopmental Disorders, Sureni Mullegama

Theses and Dissertations

Neurodevelopmental disorders (NDs) are a growing public health concern. These complex disorders cause failure of normal brain development, which leads to intellectual disability (ID) or autism in 3% of children. Accurate diagnosis of NDs is difficult due to complex overlapping phenotypes. Moreover, associations between phenotypically similar NDs and their overlapping molecular mechanisms remain unidentified. The chromosome 2q23.1 region is a newly discovered disease region. We have recently identified a novel ND, 2q23.1 deletion syndrome. The phenotype includes severe ID, significantly delayed speech, behavioral problems, seizures and short stature. This syndrome shares characteristics in common with other genetic syndromes, including Smith-Magenis …

Does Parent And Therapist Delivered Qigong Massage Therapy Decrease Sensory And Self-Regulation Impairments In Children Ages 3-6 Years Old With Autism?, Lisa A. White

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not parent and therapist delivered Qigong massage therapy decreases sensory and self-regulation impairments in children ages 3-6 years old with autism.

STUDY DESIGN: Reviewed three English primary studies published in 2005, 2009 and 2011.

DATA SOURCES: All studies were randomized controlled trials that compared a group of children with autism who received Qigong massage treatments to a controlled group of children with autism who did not receive the treatments. All studies were found using PubMED and Cochrane research databases.

OUTCOMES MEASURED: Overall reduction …

Treatment For Children With High Functioning Autism: A Comparison Of Social Stories To Musically Adapted Social Stories, Veronica M. Torres

Open Access Theses & Dissertations

The incorporation of music and social stories has been seldom tested, thus a study which uses a single-subject, alternating treatment design assesses the effects of standard social stories versus musically adapted social stories on the pragmatic abilities of an individual with high-functioning autism is presented. The goal of this project was to determine whether read social stories versus musically adapted social stories would be more beneficial in reducing problem behaviors in a child with high-functioning autism. Both types of social stories were implemented with the participant and the data supported the effectiveness of both treatments. Though the musically adapted social …

Effects Of Augmentative And Alternative Device On Echolalia In Autism, Cynthia Valenzuela

Open Access Theses & Dissertations

This study was a systematic replication of Mueller and Forbes (n.d.), which evaluated the effects of a high-tech and low-tech augmentative alternative communication (AAC) device on reducing echolalia in a verbal child with autism during conversational speech. The participant for this study was a verbal eleven-year male, who was diagnosed with autism prior to the study. A single subject alternating treatment research design was used to evaluate the effect of a high-tech speech generating AAC device (Proloquo2go) on echolalia. The participant was seen periodically twice a week for two months and periodically for one month. A functional analysis(Prizant & Rydell, …

Children With Asd And Their Experience Of Friendship And Co-Occupation, Joshua Eric Line

Online Theses and Dissertations

This study set out to answer four questions regarding the friendships of children with ASD: 1) what elements of friendship are most important, 2) what elements of friendship are most common, 3) do these elements change with peer exposure, and 4) how do these children experience co-occupations? Phenomenological methods were used to analyze interviews of three children with ASD (age 10). Literature review included discussion of definitions of friendship, and definitions of co-occupation, as relevant to the study. Identified themes include the lunchroom as a social context, reciprocity through co-occupations, trust, keeping friends means being a good friend, engagement in …

The Sensory Processing Patterns And Activity Choices Of A Child With Autism Spectrum Disorder: A Mixed-Methods Case Study, Valerie Miller

Online Theses and Dissertations

It is estimated that up to 95% of children with autism spectrum disorder experience sensory processing problems. Minimal research is available on the relationship between specific sensory processing patterns, activity preference and behavior patterns in children. It is hypothesized that if children participate in play activities that support their sensory needs, they will experience less behavioral problems, more self-regulating behavior and a higher quality of life. This mixed-methods case study examines how a child with autism spectrum disorder participates in activities and looks at if those activities support sensory needs, thus reinforcing self-regulatory behaviors.

The Silhouettes Of Autism, Chloe J. Dobbert

CMC Senior Theses

My passion as a student at the Claremont Colleges is to help children with Autism Spectrum Disorder grow and learn as normal children and to help prepare them for life outside the Autism Center at Claremont McKenna College. In my thesis project, I am exploring the concept of silhouettes through photography and my perceptions of the stories told to me by the children I teach. Esthetically, I am inspired by Kara Walker’s installation of large cutout silhouettes but I am using different mediums to accomplish my project: Artistically, I am inspired by the detailed descriptions of the obsessive stories and …

A Comparison Of A Matrix Programming And Standard Discrete Trial Training Format To Teach Two-Component Tacts, Emily Braff

USF Tampa Graduate Theses and Dissertations

Teaching using matrix programming has been shown to result in recombinative generalization. However, this procedure has not been compared to more standard discrete trial training formats such as DTT. This study compared acquisition and recombinative generalization of two-component tacts using each procedure. Matrix training was found to be more efficient than the DTT format. Half the amount of teaching was required to teach roughly the same number of targets using matrix training as compared to DTT.