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Full-Text Articles in Medicine and Health Sciences
Improving The Accuracy Of Radiation Pneumonitis Dose Response Models, Yevgeniy Vinogradskiy
Improving The Accuracy Of Radiation Pneumonitis Dose Response Models, Yevgeniy Vinogradskiy
Dissertations & Theses (Open Access)
The prognosis for lung cancer patients remains poor. Five year survival rates have been reported to be 15%. Studies have shown that dose escalation to the tumor can lead to better local control and subsequently better overall survival. However, dose to lung tumor is limited by normal tissue toxicity. The most prevalent thoracic toxicity is radiation pneumonitis. In order to determine a safe dose that can be delivered to the healthy lung, researchers have turned to mathematical models predicting the rate of radiation pneumonitis. However, these models rely on simple metrics based on the dose-volume histogram and are not yet …
A Quantitative Method For Reproducible Ionization Chamber Alignment To A Water Surface For External Beam Radiation Therapy Depth Dose Measurements, James Ververs
Theses and Dissertations
Ionization chambers (ICs) are the most commonly used detectors for radiation therapy dose measurements. Typical IC measurements use cylindrical ICs in a water phantom and therefore require initial IC alignment to the water surface. This alignment has long been ignored and only recently has a qualitative governing recommendation been made. This thesis describes a reproducible methodology for quantitative ionization chamber water surface alignment. Depth-ionization measurements are taken with twenty-eight IC designs under varying conditions including, but not limited to, changes in scan direction, speed, and resolution, radiation beam type, field size, energy, and electron contamination. Measurements are acquired using standard …