Medicine and Health Sciences Commons^™

The Development Of An Oral Inhalation Dosage Form Antinauseant, Kit Michael Mills

University of the Pacific Theses and Dissertations

It would seem appropriate that studies be conducted on the development of an oral inhalation dosage form antinauseant. The present project will consist of developing and testing a series of aerosol formulations to determine their feasibility in antinauseant therapy. In vitro pressure, valve release, spray pattern, particle size, and aging studies will be performed. The present work will also include an in vivo evaluation of promising formulations.

In Vitro Resorption Characteristics Of Selected Diuretic Compounds By Thedesaga Resomat, Donald Gene Floriddia

University of the Pacific Theses and Dissertations

An in vitro method was tested whereby the processes of dissolution and distribution of active ingredient into a lipoid solvent were combined in one model and evaluated.

The objectives of this research project were: (1) to evaluate the efficacy of the in vitro model known as the Desaga Resomat, in the testing of gastrointestinal absorption; (2) to apply the procedure and instrument to a group of therapeutically important products in determining their absorption characteristics; (3) to graphically illustrate the absorption profile of a specific drug as per cent absorbed vs. time, simulating in vivo absorption; (4) to compare the profile …