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Studies On The Biology Of The Neuroactive Amines; A Morphologic And Pharmacologic Approach, Herbert Meltzer

Yale Medicine Thesis Digital Library

[From the Introduction] The discoveries that histamine is found in the mast cells of a myriad of species, that 5-hydroxytryptamine is found in the mast cells of the rat and mouse, and that these amines are largely bound in granules made this cell of great interest to the student of amine biology. It meant that the mast cell, along with the cells of the adrenal medulla and the blood platelets could serve as a model system for the amine biology of the vertebrate nervous system whose complexity makes a direct experimental approach extremely difficult. Thus, information about amine synthesis, destruction, …