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Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Social Script Ipad Application Versus Usual Care Before Undergoing Medical Imaging: Two Case Studies Of Children With Autism, Norah L. Johnson Phd, Rn, Cpnp, Octavia Alexis Bree
Social Script Ipad Application Versus Usual Care Before Undergoing Medical Imaging: Two Case Studies Of Children With Autism, Norah L. Johnson Phd, Rn, Cpnp, Octavia Alexis Bree
College of Nursing Faculty Research and Publications
Autism spectrum disorders (ASDs) are neurodevelopmental disorders of socialization, communication, and repetitive behaviors. Children with ASD have underlying anxiety leading to challenging behaviors in unfamiliar situations. The anxiety impacts timely completion of an imaging procedure. The purpose of the case study was to describe the process of the social script intervention delivered using the iPad application on parent and child anxiety, child behaviors, and imaging procedure length between two parent and child dyads. The case study of two parent-child dyads demonstrated the process for comparing the social script intervention iPad app for preparing for imaging versus usual care. Parent anxiety …
Relationship Between Sensory Sensitivities And Cognitive And Adaptive Abilities In Children With Autism Spectrum Disorders, Laura Pendergast
Relationship Between Sensory Sensitivities And Cognitive And Adaptive Abilities In Children With Autism Spectrum Disorders, Laura Pendergast
Honors Scholar Theses
Sensory sensitivities are widely reported among individuals with ASD. These sensory sensitivities can be classified as over-responsivity, under-responsivity, or seeking of sensory stimulation. Following recent changes in the diagnostic criteria, sensory sensitivities are considered a key feature of the behavioral phenotype of ASDs. Despite their significance, sensory sensitivities have been largely underestimated. Therefore, more research in this area may reveal important information about the influence of sensitivities on functioning, as well as the underlying causes of the symptoms. This study investigated a possible relationship between sensory sensitivities and cognitive and adaptive abilities in children with ASD. The sample included 29 …
Fatty Acids Increase Neuronal Hypertrophy Of Pten Knockdown Neurons, Catherine J. Fricano, Tyrone Despenza, Paul W. Frazel, Meijie Li, A. James O'Malley, Gary Westbrook, Bryan Luikart
Fatty Acids Increase Neuronal Hypertrophy Of Pten Knockdown Neurons, Catherine J. Fricano, Tyrone Despenza, Paul W. Frazel, Meijie Li, A. James O'Malley, Gary Westbrook, Bryan Luikart
Dartmouth Scholarship
Phosphatase and tensin homolog (Pten) catalyzes the reverse reaction of PI3K by dephosphorylating PIP3 to PIP2. This negatively regulates downstream Akt/mTOR/S6 signaling resulting in decreased cellular growth and proliferation. Co-injection of a lentivirus knocking Pten down with a control lentivirus allows us to compare the effects of Pten knockdown between individual neurons within the same animal. We find that knockdown of Pten results in neuronal hypertrophy by 21 days post-injection. This neuronal hypertrophy is correlated with increased p-S6 and p-mTOR in individual neurons. We used this system to test whether an environmental factor that has been implicated in cellular hypertrophy …
Consistency Between Research And Clinical Diagnoses Of Autism Among Boys And Girls With Fragile X Syndrome, Jessica Klusek, G E. Martin, M Losh
Consistency Between Research And Clinical Diagnoses Of Autism Among Boys And Girls With Fragile X Syndrome, Jessica Klusek, G E. Martin, M Losh
Faculty Publications
No abstract provided.
The Association Between Autism Spectrum Disorders And Secondhand Tobacco Exposure, Bhupinder Kaur
The Association Between Autism Spectrum Disorders And Secondhand Tobacco Exposure, Bhupinder Kaur
Master of Public Health Program Student Publications
Second hand tobacco smoke exposure has been associated with neurobehavioral disorders among children. The objective of this study was to evaluate the relationship between second hand smoking and autism spectrum disorders (ASD) in children in the United States. Parent-reported postnatal tobacco exposure inside and outside the house and ASD diagnosis was examined in children younger than 12 years using the 2011-2012 National Survey on Children's Health. The physician diagnosis of current ASD as reported by the parents was used as the outcome variable. Univariate and multivariate logistic regression models adjusted for potential confounders were used to assess the associations. Of …
Idiots Savants, Retarded Savants, Talented Aments, Mono-Savants, Autistic Savants, Just Plain Savants, People With Savant Syndrome, And Autistic People Who Are Good At Things: A View From Disability Studies, Joseph N. Straus
Publications and Research
People identified as idiot savants have long comprised an identifiable group (a high level of skill in the context of perceived mental deficiency) whose story has mostly been told by psychiatrists and psychologists within a medicalized model of disability that assumes deficiency and seeks remediation and normalization. More recently, people identified as savants have become common figures of literary and cinematic representation. Both of these narrative frames have enfreaked them as alien Others, whose gifts and disabilities place them outside the normal run of human intelligence and creativity. With a focus on music, this article tries to see through these …
Hypothesis Testing In Normal Admixture Models To Detect Heterogeneous Genetic Signals, Qian Fan, Richard Charnigo, Zohreh Talebizadeh, Hongying Dai
Hypothesis Testing In Normal Admixture Models To Detect Heterogeneous Genetic Signals, Qian Fan, Richard Charnigo, Zohreh Talebizadeh, Hongying Dai
Manuscripts, Articles, Book Chapters and Other Papers
In this work we consider a three-component normal mixture model in which one component is known to have mean zero and the other two contaminating components have a nonnegative and a nonpositive mean respectively, while all three components share a common unknown variance parameter. One potential application of this model may be in prioritizing statistical scores obtained in biological experiments, including genetics data. Such a mixture model may be useful in describing the distribution of numerous Z test statistics corresponding to different genes or SNPs, such that a “significant” Z test statistic for a particular gene suggests its connection to …