Medicine and Health Sciences Commons^™

Factors Associated With Stress Among Adolescents In The City Of Nawabshah, Pakistan, Yasmin Parpio, Salima Farooq, Saleema A. Gulzar, Ambreen Tharani, Tazeen Saeed Ali, Fawad Javed

School of Nursing & Midwifery

Objective: To identify the risk factors of stress among school-going adolescents in rural Nawabshah, Pakistan.
Methods: The cross-sectional study was conducted in 2005, comprising 800 school-going children of 10-16 years of age in Nawabshah, through simple random sampling. Data was collected using a structured questionnaire to assess the potential risk factors of stress. A modified version of Perceived stress scale was utilized to measure stress level. SPSS 12 was used for statistical analysis, while multiple linear regression analysis was run to identify the factors associated with stress in the study population.
Results: Of the total, 529 (66%) children belonged to …

Racism And Illicit Drug Use Among African American Women: The Protective Effects Of Ethnic Identity, Affirmation, And Behavior, Danelle Stevens-Watkins, Brea Perry, Kathi L. Harp, Carrie B. Oser

Sociology Faculty Publications

Though recent evidence indicates that rates of illicit drug use among African American women are now higher than the national average, little is known about the etiology of substance use in this population. In addition, the effects of racism and other cultural factors are understudied and may be unique amongst African American women. This cross-sectional study explores risk and protective factors for drug use among 204 African American women. More specifically, associations between racism experiences and drug use are investigated in the context of potential moderating influences (i.e., psychosocial resources, social safety net variables, and cultural identity and practices). Findings …

Effects Of Physical Stress And Maturational Changes On Hypothalamic Pituitary Adrenal Axis Function Through Cortisol Analysis, Amy Granger, Allison Henry, Lauren Lilliencrantz, Amanda Smith, Paul Srnis, William Van Schepen, Elisha R. Injeti

Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session

Cortisol is a versatile hormone that possesses both catabolic and anabolic functions in the body, such as increasing the blood glucose levels through gluconeogenesis and metabolizing carbohydrates, proteins, and fats.1234 Cortisol levels are controlled by communication of the hyptothalamic-pituitary-adrenal axix (HPA axis). Plasma concentration of cortisol adheres to a diurnal rhythm, meaning that cortisol levels are highest in the morning and taper off throughout the day.

Severe Stress Switches Crf Action In The Nucleus Accumbens From Appetitive To Aversive., Julia C Lemos, Matthew J Wanat, Jeffrey S Smith, Beverly A S Reyes, Nick G Hollon, Elisabeth J Van Bockstaele, Charles Chavkin, Paul E M Phillips

Farber Institute for Neuroscience Faculty Papers

Stressors motivate an array of adaptive responses ranging from 'fight or flight' to an internal urgency signal facilitating long-term goals. However, traumatic or chronic uncontrollable stress promotes the onset of major depressive disorder, in which acute stressors lose their motivational properties and are perceived as insurmountable impediments. Consequently, stress-induced depression is a debilitating human condition characterized by an affective shift from engagement of the environment to withdrawal. An emerging neurobiological substrate of depression and associated pathology is the nucleus accumbens, a region with the capacity to mediate a diverse range of stress responses by interfacing limbic, cognitive and motor circuitry. …

Stress, Job Satisfaction And Work Hours In Medical And Surgical Residency Programmes In Private Sector Teaching Hospitals Of Karachi, Pakistan, Sameer-Ur-Rehman, Rohail Kumar, Nabeel Siddiqui, Zain Shahid, Sadia Syed, Masood Kadir

Community Health Sciences

Objective: To assess stress levels, job satisfaction and working hours of the residents in Medicine and Surgery and to explore a correlation among the three factors.Methods: The questionnaire-based. Cross-sectional study was conducted in 2011 at two tertiary level teaching hospitals in Karachi, Pakistan (Ziauddin University Hospital and Aga Khan University Hospital, Karachi, Pakistan). The study population comprised 176 residents, General Health Questionnaire-12 was used to assess the mental health of the residents and a standardised Job Satisfaction Survey tool was used to assess their work satisfaction.Results: A total of 176 residents participated in the study; 115 (65%) from Medicine, and …

Human Genome-Wide Association And Mouse Knockout Approaches Identify Platelet Supervillin As An Inhibitor Of Thrombus Formation Under Shear Stress., Leonard C. Edelstein, Elizabeth J. Luna, Ian B. Gibson, Molly Bray, Ying Jin, Altaf Kondkar, Srikanth Nagalla, Nacima Hadjout-Rabi, Tara C. Smith, Daniel Covarrubias, Stephen N. Jones, Firdos Ahmad, Moritz Stolla, Xianguo Kong, Zhiyou Fang, Wolfgang Bergmeier, Chad Shaw, Suzanne M. Leal, Paul Bray

Department of Medicine Faculty Papers

BACKGROUND: High shear force critically regulates platelet adhesion and thrombus formation during ischemic vascular events. To identify genetic factors that influence platelet thrombus formation under high shear stress, we performed a genome-wide association study and confirmatory experiments in human and animal platelets.

METHODS AND RESULTS: Closure times in the shear-dependent platelet function analyzer (PFA)-100 were measured on healthy, nondiabetic European Americans (n=125) and blacks (n=116). A genome-wide association (P

CONCLUSIONS: We show for the first time that (1) platelets contain supervillin; (2) platelet thrombus formation in the PFA-100 is associated with human SVIL variants and low SVIL expression; and (3) …

Stress, Coping And Suicide Ideation In Chinese College Students, Xiaoyun Zhang, Haiping Wang, Yan Ruth Xia, Xiaohong Liu, Eunju Jung

Department of Child, Youth, and Family Studies: Faculty Publications

The study was to examine 1) whether stress and coping styles could significantly predict the probability of suicide ideation; 2) and whether coping styles were mediators or moderators on the association between life stress and suicide ideation. The survey was conducted in a sample of 671 Chinese college students. Approximately twenty percent students reported having suicide ideation. Life stress, active coping styles, and passive coping styles all had independent effect on the probability of suicide ideation. Passive coping styles, especially fantasizing, mediated the relation between life stress and suicide ideation. Moderation hypotheses were not supported. Implications of the findings and …

Impact Of The Project P.A.T.H.S. In The Junior Secondary School Years: Objective Outcome Evaluation Based On Eight Waves Of Longitudinal Data, Daniel T. L. Shek, Cecilia M. S. Ma

Pediatrics Faculty Publications

To assess the effectiveness of the Tier 1 Program of the Project P.A.T.H.S., a randomized group trial with eight waves of data collected was carried out. At the fifth year of data collection, 19 experimental schools (n = 2, 662 students) and 24 control schools (n = 3, 272 students) participated in the study. Analyses based on individual growth curve modeling showed that participants in the experimental schools displayed better positive youth development than did participants in the control schools in terms of different indicators derived from the Chinese Positive Youth Development Scale, including moral competence and behavioral competence and …

Perceived Stress And Self‑Rated Health Of Haitian And African Americans With And Without Type 2 Diabetes, Fatma G. Huffman, Joan A. Vaccaro, Sahar Ajabshir, Gustavo G. Zarini, Joel C. Exebio, Zisca Dixon

Department of Dietetics and Nutrition

Background: Blacks have a higher incidence of diabetes and its related complications. Self-rated health (SRH) and perceived stress indicators are associated with chronic diseases. The aim of this study was to examine the associations between SRH, perceived stress and diabetes status among two Black ethnicities.
Materials and Methods: The cross-sectional study included 258 Haitian Americans and 249 African Americans with (n = 240) and without type 2 diabetes (n = 267) (N = 507). Recruitment was performed by community outreach.
Results: Haitian-Americans were less likely to report ‘fair to poor’ health as compared to African Americans [OR=0.58 (95% CI: …

Cannabinoid Receptor Involvement In Stress-Induced Cocaine Reinstatement: Potential Interaction With Noradrenergic Pathways, Linda K. Vaughn, John R. Mantsch, Oliver Vranjkovic, G. Stroh, M. Lacourt, M. Kreutter, Cecilia J. Hillard

Biomedical Sciences Faculty Research and Publications

This study examined the role of endocannabinoid signaling in stress-induced reinstatement of cocaine seeking and explored the interaction between noradrenergic and endocannabinergic systems in the process. A well-validated preclinical model for human relapse, the rodent conditioned place preference assay, was used. Cocaine-induced place preference was established in C57BL/6 mice using injections of 15 mg/kg cocaine. Following extinction of preference for the cocaine-paired environment, reinstatement of place preference was determined following 6 min of swim stress or cocaine injection (15 mg/kg, i.p.). The role of endocannabinoid signaling was studied using the cannabinoid antagonist AM-251 (3 mg/kg, i.p.). Another cohort of mice …

The Effects Of Adolescent Binge Drinking On Corticotropin-Releasing Factor Cells In The Amygdala And Social Predictors Of Alcohol Intake In Male And Female Rats, Chrisanthi Karanikas

Masters Theses 1911 - February 2014

Alcohol is one of the most common drugs of choice among adolescents. Normally, the method of consumption is drinking large quantities of alcohol in short periods of time, otherwise known as “binge drinking.” Corticotropin releasing factor (CRF) stress peptide producing cells in central nucleus of the amygdala (CeA) has been implicated in behavioral responses to stress and addiction. The goals of this thesis were to determine the effects of voluntary binge drinking in adolescence and vapor-induced alcohol dependence in adulthood on CRF cells in the CeA. These studies were done using an operant model of voluntary binge drinking in rodents …

Explaining The Longitudinal Association Between Puberty And Depression: Sex Differences In The Mediating Effects Of Peer Stress, Colleen S. Conley, Karen D. Rudolph, Fred B. Bryant

Psychology: Faculty Publications and Other Works

This research investigated whether exposure to peer stress serves as one pathway through which pubertal development contributes to depression over time, differentially for girls and boys. Youth (N = 149; 9.6–14.8 years) and their caregivers provided information at two waves, 1 year apart, on puberty (Wave 1), peer stress (occurring between Waves 1 and 2), and depression (Waves 1 and 2). Structural equation modeling analyses examined sex differences in the extent to which peer stress mediated the impact of pubertal status and timing on subsequent depression (i.e., tests of moderated mediation). Significant sex-moderated mediation was found for both pubertal status …

The Impact Of A Naturalistic Stressor On Spontaneous Alternation Behavior: A New Animal Model Of Ocd, Christina Finch

Behavioral Neuroscience Honors Papers

Over the past few decades, various animal models of obsessive compulsive disorder (OCD) have been developed. Similarly, various stressors have been used throughout animal research. The Spontaneous Alternation Behavioral (SAB) model is a well-established model of OCD while 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) has recently become a popular naturalistic stressor. This study linked the two together, thus modeling the effect of stress on OCD behaviors. After living in an enriched or standard environment for 3 weeks, male Sprague-Dawley rats were exposed to either TMT or no odor, and then were examined in the SAB task. Unlike what was hypothesized, the enriched environment proved …

Endoplasmic Reticulum Stress And Lipid Metabolism, Huiping Zhou, Kezhong Zhang, Sabina Janciauskiene, Xiaokun Li

Microbiology and Immunology Publications

Endoplasmic reticulum (ER) is an elaborate cellular organelle essential for protein folding, calcium homeostasis, and lipid biosynthesis. Disruption of ER homeostasis imposes stress on the ER and subsequently leads to accumulation of unfolded or misfolded proteins in the ER lumen—a condition termed ER stress. In response to ER stress, a group of intracellular signaling pathways originated from the ER, collectively termed ER stress response, are activated to alter transcriptional and translational programs in the stressed cells. ER stress response has been linked to various human diseases associated with dyslipidemia, such as inflammatory diseases, obesity, diabetes, alcoholic and nonalcoholic liver diseases, …

Caring For Self And Others: Increasing Health Care Students’ Healthy Behaviors, Mary Ann Stark, Tena Hoekstra, Debra Lindstrom Hazel, Barbara Barton

Social Work Faculty Publications

Objective: Living a healthy lifestyle in order to manage stress encountered in the health care system is important for health care professionals. The purpose of this study was to increase healthy behaviors of undergraduate students in professional health care majors by introducing a health promotion intervention in a required course. Participants: The sample consisted of 201 undergraduate health professional students from nursing (NUR) (n = 82, 40.8%), occupational therapy (OT) (n = 72, 35.8%), and speech- language pathology (SLP) (n = 47, 23.4%). Methods: A pretest-posttest comparison group design was used. The NUR and OT students received a health promotion …

Women At War: Understanding How Women Veterans Cope With Combat And Military Sexual Trauma, Kristin M. Mattocks, Sally G. Haskell, Erin E. Krebs, Amy C. Justice, Elizabeth M. Yano, Cynthia Brandt

Public Health Resources

The wars in Iraq (Operation Iraqi Freedom, OIF) and Afghanistan (Operation Enduring Freedom, OEF) have engendered a growing population of US female veterans, with women now comprising 15% of active US duty military personnel. Women serving in the military come under direct fire and experience combatrelated injuries and trauma, and are also often subject to in-service sexual assaults and sexual harassment. However, little is known regarding howwomen veterans cope with these combat and military sexual trauma experiences once they return from deployment. To better understand their experiences, we conducted semi-structured interviews with nineteen OEF/OIF women veterans between JanuaryeNovember 2009. Women …

A Discussion Of The Mental Health Of Public School Teachers, Gary W. Ballou

All Faculty Scholarship for the College of Education and Professional Studies

It has been suggested that public school teachers are exposed to highly stressful situations which are related to psychological and psychiatric problems. Unfortunately, there is no quantitative data suggesting which factors contribute to improving the mental health of American teachers, nor have there been any prior studies that have directly compared the factors associated with mental health disturbances between teachers and workers in other occupations in the United States. In light of this, I felt it crucial to find the factors associated with psychological/psychiatric problems in public school teachers in the United States using an appropriate reference professional group.

Effects Of Arterial Strain And Stress In The Prediction Of Restenosis Risk: Computer Modeling Of Stent Trials, Shijia Zhao, Linxia Gu, Stacey R. Froemming

Department of Mechanical and Materials Engineering: Faculty Publications

Purpose — In-stenting restenosis is one of the major complications after stenting. Clinical trials of various stent designs have reported different restenosis rates. However, quantitative correlation between stent features and restenosis statistics is scant. In this work, it is hypothesized that stress concentrations on arterial wall caused artery injury, which initiates restenosis. The goal is to assess the correlation between stent-induced arterial stress and strain and the documented restenosis rates.

Methods — Six commercially available stents, including balloon-expandable stents and self-expanding stents, were virtually implanted into the arteries through finite element method. The resulted peak Von Mises stress, principal stress, …

Prescient Human Fetuses Thrive, Curt A. Sandman, Elyssia Poggi Davis, Laura M. Glynn

Psychology Faculty Articles and Research

Fetal detection of adversity is a conserved trait that allows many species to adapt their early developmental trajectories to ensure survival. According to the fetal-programming model, exposure to stressful or hostile conditions in utero is associated with compromised development and a lifelong risk of adverse health outcomes. In a longitudinal study, we examined the consequences of prenatal and postnatal exposure to adversity for infant development. We found increased motor and mental development during the 1st year of life among infants whose mothers experienced congruent levels of depressive symptoms during and after pregnancy, even when the levels of symptoms were relatively …

Understanding Stress In The Operating Room: A Step Toward Improving The Work Environment, Robert V. Topp, Jill Berger, Anthony Vowels

College of Nursing Faculty Research and Publications

Job-related stress is an important factor predicting staff satisfaction and position turnover among nursing staff, particularly in the operating room. The purpose of this study was to examine the perceived amount of stress elicited by events in the perioperative environment, the frequency of those events, and the impact of those events on the perceived stress of operating room nurses (ORNs) and operating room technologists (ORTs). The Survey on Stress in the OR instrument, which was used to query the subjects, exhibited high internal consistency of all items. The findings indicated that the ORNs and the ORTs exhibited remarkable similarities between …

A Qualitative Study Of Mothers Who Work Full-Time As Hospital Floor Nurses, Michael W. Firmin, Megan Bailey Pathammavong

Psychology Faculty Publications

We conducted qualitative interviews with a sample of 13 female floor nurses in a Midwest hospital. The women worked full-time and also had children at home for whom they provided care. The overall four results reported include particular challenges they faced in their dual-roles, including separating home from work, high stress, sleep deprivation, odd hours, and difficulty in advancing due to home life pressures. The nurses also related perceived assets and drawbacks of their profession for the given season of life. They described what they believed to be necessities for success in the dual-roles of professional nurse and care taker. …