Medicine and Health Sciences Commons^™

Differential Actions Of Ethanol And Trichloroethanol At Sites In The M3 And M4 Domains Of The Nmda Receptor Glun2a (Nr2a) Subunit, Ak Salous, H Ren, Ka Lamb, Xiang-Qun Hu, Rh Lipsky, Robert W. Peoples

Biomedical Sciences Faculty Research and Publications

Background and purpose:  Alcohol produces its behavioural effects in part due to inhibition of N-methyl-d-aspartate (NMDA) receptors in the CNS. Previous studies have identified amino acid residues in membrane-associated domains 3 (M3) and 4 (M4) of the NMDA receptor that influence ethanol sensitivity. In addition, in other alcohol-sensitive ion channels, sedative-hypnotic agents have in some cases been shown to act at sites distinct from the sites of ethanol action. In this study, we compared the influence of mutations at these sites on sensitivity to ethanol and trichloroethanol, a sedative-hypnotic agent that is a structural analogue of ethanol.

Experimental approach: …

Increased Drinking In A Trial Of Treatments For Marijuana Dependence: Substance Substitution?, Ronald M. Kadden, Mark D. Litt, Elise Kabela-Cormier, Nancy M. Petry

UCHC Articles - Research

This report examines whether participants in a study of treatments for marijuana dependence may have increased their use of alcohol when they reduced or ceased marijuana use. Participants were randomly assigned to one of four psychosocial treatments and followed at 3-month intervals for one-year. Findings are from 207 cases with data at posttreatment and at least one other follow-up. 73% of cases reported an increase of at least 10% in drinking days over their level at intake, and 65% reported an increase of at least 10% in drinks per drinking day. Drinking increases were not related to treatment condition nor …

Alcohol And Cardio-Respiratory Deaths In Chinese: A Population-Based Case-Control Study Of 32,462 Older Hong Kong, Mary Schooling, Tai Hing Lam, Sai Yin Ho, Yao He, Kwok Hang Mak, Gabriel M. Leung

Publications and Research

Background
In observational studies moderate alcohol use reduces cardio-respiratory mortality. However observational studies may be biased by many factors including residual confounding by unmeasured differences between moderate alcohol users and other groups or by changes in alcohol use with ill-health and aging. We used two different analytic strategies in an under-studied population, i.e. southern Chinese, to provide an assessment of the specific impact of moderate alcohol use on mortality from ischemic heart disease (IHD) and chronic obstructive pulmonary diseases (COPD).

Methods
In a population-based case-control study of all adult deaths in Hong Kong Chinese in 1998, we used adjusted logistic …

Evaluation Of Two Web-Based Alcohol Interventions For Mandated College Students, Diana M. Doumas, Lisa L. Mckinley, Phares Book

Counselor Education Faculty Publications and Presentations

This study evaluated the efficacy of two web-based interventions aimed at reducing heavy drinking in mandated college students. Mandated students were randomly assigned to one of two conditions: web-based personalized normative feedback (WPNF) or web-based education (WE). As predicted, results indicated mandated students in the WPNF condition reported significantly greater reductions in weekly drinking quantity, peak alcohol consumption, and frequency of drinking to intoxication than students in the WE condition at a 30-day follow-up. Although not statistically significant, there was a similar trend for changes in alcohol-related problems. Mandated students in the WPNF group also reported significantly greater reductions in …

The Impact Of More Visible Standard Drink Labelling On Youth Alcohol Consumption: Helping Young People Drink (Ir)Responsibly?, Sandra C. Jones, Parri Gregory

Faculty of Health and Behavioural Sciences - Papers (Archive)

Introduction and Aims. In response to increasing concerns about excessive drinking among young people the Australian alcohol industry announced that it will introduce more visible standard drink labels. This study sought to examine whether young people use this information in a way that decreases, or increases, alcohol-related harms. Design and Methods. Six focus groups with students enrolled in an undergraduate university course in a large regional city in New South Wales, recruited by direct approach on the university grounds and via an online message posted on the university bulletin board. Results: The majority of the participants reported that they are …

Alcohol Energy Drinks: Engaging Young Consumers In Co-Creation Of Alcohol Related Harm, Sandra C. Jones, Lance Barrie

Faculty of Health and Behavioural Sciences - Papers (Archive)

Alcohol-energy drinks are a relatively new entry to the alcohol market, but have rapidly gained popularity among young drinkers. Unfortunately, these products are also associated with higher levels of alcohol-related harm, including negative health effects and increased levels of aggression and violence. This paper reports on the social image functions served by these products, as perceived by university students; and suggests that there is a need to look beyond alcohol advertising to other factors that increase consumption – including pricing, distribution, use of social media, and consumer co-creation of brand image. Keywords: attitude, behaviour, experience, perception, public health, responsibility, alcohol

Assessing The Cumulative Impact Of Alcohol Marketing On Young People's Drinking: Cross Sectional Data Findings, Ross Gordon, Fiona Harris

Faculty of Health and Behavioural Sciences - Papers (Archive)

This article provides first wave data from a study designed to examine the impact of the full range of marketing communication techniques used by the UK alcohol industry, and their cumulative effect on alcohol initiation and youth drinking patterns. The study is of a longitudinal cohort design and was conducted amongst secondary school pupils in Scotland. A cohort of 920 2nd year school pupils participated and cross sectional data was collected and analysed. Regression models with multiple control variables examined the relationship between awareness of and involvement with a range of alcohol marketing activities, and drinking and associated risky behaviours. …

Critical Social Marketing: Assessing The Impact Of Alcohol Marketing On Youth Drinking, Ross Gordon, Fiona Harris, Anne Marie Mackintosh

Faculty of Health and Behavioural Sciences - Papers (Archive)

No abstract provided.