Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Induction Of Endogenous Γ-Globin Gene Expression With Decoy Oligonucleotide Targeting Oct-1 Transcription Factor Consensus Sequence, Xiaoxin S. Xu, Xin Hong, Gan Wang
Induction Of Endogenous Γ-Globin Gene Expression With Decoy Oligonucleotide Targeting Oct-1 Transcription Factor Consensus Sequence, Xiaoxin S. Xu, Xin Hong, Gan Wang
Wayne State University Associated BioMed Central Scholarship
Abstract
Human β-globin disorders are relatively common genetic diseases cause by mutations in the β-globin gene. Increasing the expression of the γ-globin gene has great benefits in reducing complications associated with these diseases. The Oct-1 transcription factor is involved in the transcriptional regulation of the γ-globin gene. The human γ-globin genes (both Aγ and Gγ-globin genes) carry three Oct-1 transcription factor consensus sequences within their promoter regions. We have studied the possibility of inducing γ-globin gene expression using decoy oligonucleotides that target the Oct-1 transcription factor consensus sequence. A double-stranded 22 bp decoy oligonucleotide containing the Oct-1 consensus sequence was …