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Separate And Concomitant Use Of Lamotrigine, Lithium, And Divalproex In Bipolar Disorders., Daniel Z Lieberman, Frederick K Goodwin

Psychiatry and Behavioral Sciences Faculty Publications

Expert consensus emphasizes the need for better recognition and accurate diagnosis of bipolar disorder. Current research on lithium, divalproex, and lamotrigine provides new insight into the effective management of this illness. Advances in identifying the mechanism of action of mood stabilization has focused on signaling pathways within the cell that are associated with neurotrophic effects. Clinical research has led to confirmatory evidence of the efficacy of lithium in all phases of bipolar disorder, with the greatest effects seen in the treatment and prevention of mania. Compared to divalproex, lithium also has been found to have greater efficacy in the prevention …

Predictors Of Paralysis In The Rheumatoid Cervical Spine In Patients Undergoing Total Joint Arthroplasty., Jonathan N Grauer, Edwin M Tingstad, Nahshon Rand, Michael J Christie, Alan Hilibrand

Rothman Institute Faculty Papers

BACKGROUND: Rheumatoid arthritis is sometimes associated with radiographic evidence of instability of the cervical spine, most commonly an abnormal subluxation between vertebrae. When this instability compromises the space that is available for the spinal cord, it may be predictive of paralysis. However, the prevalence of radiographic signs of instability that are predictive of paralysis among patients with nonspinal orthopaedic manifestations of rheumatoid arthritis is unknown.

METHODS: Radiographs of the cervical spine of patients with rheumatoid arthritis who had undergone total joint arthroplasty over a five-year period were retrospectively reviewed. The radiographs were evaluated for predictors of paralysis (a posterior atlantodental …

Serial Serum Procalcitonin Changes In The Prognosis Of Acute Stroke, Spyridon Miyakis, Petros Georgakopoulos, Maria Kiagia, Angelos Pefanis, Theodoros D. Mountokalakis, Olga Papadopoulou, Aristomenis Gonis

Faculty of Science, Medicine and Health - Papers: part A

Inflammatory response is a principal early component in the pathophysiology of stroke [1]. Serum procalcitonin (PCT)-a marker of septicemia and infection severity [2]-has also been proposed as an indicator of systemic inflammatory response in noninfectious situations [3,4]. As no data exist thus far on PCT in stroke, this study aimed to evaluate serum PCT changes in the acute stroke setting, and to correlate them with clinical and laboratory parameters and patient's outcome.