Medicine and Health Sciences Commons^™

Shorter Cwr Cycling Tests As Proxies For Longer Tests In Highly Trained Cyclists [Dataset], Chantelle Du Plessis, Mark Andrews, Lachlan J.G. Mitchell, Jodie Cochrane Wilkie, Trish King, Anthony J. Blazevich

Research Datasets

Severe-intensity constant work rate (CWR) cycling tests simulate the high-intensity competition environment and are useful for monitoring training progression and adaptation, yet impose significant physiological and psychological strain, require substantial recovery, and may disrupt athlete training or competition preparation. A brief, minimally fatiguing test providing comparable information is desirable.

Purpose: To determine whether physiological variables measured during, and functional decline in maximal power output immediately after, a 2-min CWR test can act as a proxy for 4-min test outcomes.

Methods: Physiological stress (V̇O₂ kinetics, heart rate, blood lactate concentrations ([La^-]_b)) was monitored and …

Data Supporting Development And Validation Of Liquid Chromatography Tandem Mass Spectrometry Method For The Quantitative Determination Of Bile Acids In Feces [Dataset], Armaghan Shafaei, Joanna Rees, Claus Christophersen, Amanda Devine, David Broadhurst, Mary C. Boyce

Research Datasets

The data presented here support the optimization of feces sample extraction for sensitive quantification of bile acids in human feces using LC-MS/MS. The dataset includes: Comparison between recovery of bile acids from (a) dried feces, (b) dried feces spiked with deuterated internal standards prior to drying, and (c) wet feces Short-term stability data for bile acids standard solutions and fecal extracts containing bile acids after 24 h storage at room temperature and at 6°C, Data for multiple freeze-thaw cycles on bile acids recovery in both standard solutions and fecal samples, Bile acids recovery from cold and warm extractions data

A Geospatiotemporal And Causal Inference Epidemiological Exploration Of Substance And Cannabinoid Exposure As Drivers Of Rising Us Pediatric Cancer Rates [Dataset], Albert Stuart Reece

Research Datasets

Background. Age-adjusted US total pediatric cancer incidence rates (TPCIR) rose 49% 1975-2015 for unknown reasons. Prenatal cannabis exposure has been linked with several pediatric cancers which together comprise the majority of pediatric cancer types. We investigated whether cannabis use was related spatiotemporally and causally to TPCIR.

Methods. State-based age-adjusted TPCIR data was taken from the CDC Surveillance, Epidemiology and End Results cancer database 2003-2017. Drug exposure was taken from the nationally-representative National Survey of Drug Use and Health, response rate 74.1%. Drugs included were: tobacco, alcohol, cannabis, opioid analgesics and cocaine. This was supplemented by cannabinoid concentration data from the …

Contemporary Epidemiology Of Rising Atrial Septal Defect Trends Across Usa 1991-2016: A Combined Ecological Geotemporospatial And Causal Inferential Study [Dataset], Albert Stuart Reece

Research Datasets

Background: Cardiovascular anomalies are the largest group of congenital anomalies and the major cause of death in young children, with a range of data linking rising atrial septal defect incidence (ASDI) with prenatal cannabis exposure. Objectives / Hypotheses. Is cannabis associated with ASDI in USA? Is this relationship causal?

Methods: Geospatiotemporal cohort study, 1991-2016. Census populations of adults, babies, congenital anomalies, income and ethnicity. Drug exposure data on cigarettes, alcohol abuse, past month cannabis use, analgesia abuse and cocaine taken from National Survey of Drug Use and Health (78.9% response rate). Cannabinoid concentrations from Drug Enforcement Agency. Inverse probability weighted …

Broad Spectrum Epidemiological Contribution Of Cannabis, Tobacco And Alcohol To The Teratological Profile Of Northern New South Wales: Geospatial And Causal Inference Analysis [Dataset], Albert Stuart Reece

Research Datasets

Background. Whilst cannabis commercialization is occurring rapidly guided by highly individualistic public narratives, evidence that all congenital anomalies (CA) increase alongside cannabis use in Canada, a link with 21 CA’s in Hawaii, and rising CA’s in Colorado indicate that transgenerational effects can be significant and impact public health. It was therefore important to study Northern New South Wales (NNSW) a known cannabis use centre.

Methods. Design: Cohort. 2008-2015. Setting: NNSW and Queensland (QLD), Australia. Participants. Whole populations. Exposures. Tobacco, Risky Alcohol, Annual cannabis. Source: National Drug Strategy Household Surveys 2010, 2013. Main Outcomes. CA Rates. NNSW-QLD comparisons. Geospatial and causal …

Co-Occurrence Across Time And Space Of Drug- And Cannabinoid- Exposure And Adverse Mental Health Outcomes In The National Survey Of Drug Use And Health Dataset 2: Combined Ecological Geotemporospatial And Causal Inference Analysis [Dataset], Albert Stuart Reece

Research Datasets

Background: Whilst many studies have linked increased drug and cannabis exposure to adverse mental health (MH) outcomes their effects on whole populations and geotemporospatial relationships are not well understood.

Objectives: Determine: (1) if cannabis use is associated with major MH outcomes ascross space and time, (2) if such impacts are robust to multivariable adjustment and (3) if the relationship is causal.

Methods. Ecological cohort study of National Survey of Drug Use and Health (NSDUH) geographically-linked substate-shapefiles 2010-2012 and 2014-2016 supplemented by five-year US American Community Survey. Drugs: cigarettes, alcohol abuse, last-month cannabis use and last-year cocaine use. MH: any mental …

Cannabis Consumption Patterns Explain The East-West Gradient In Canadian Neural Tube Defect Incidence: An Ecological Study [Dataset], Albert Stuart Reece, Gary Kenneth Hulse

Research Datasets

While a known link between prenatal cannabis exposure and anencephaly exists, the relationship of prenatal cannabis exposure with neural tube defects (NTDs) generally has not been defined. Published data from Canada Health and Statistics Canada were used to assess this relationship. Both cannabis use and NTDs were shown to follow an east-west and north-south gradient. Last year cannabis consumption was significantly associated (P < .0001; cannabis use–time interaction P < .0001). These results were confirmed when estimates of termination for anomaly were used. Canada Health population data allowed the calculation of an NTD odds ratio) of 1.27 (95% confidence interval = 1.19-1.37; P < 10−11) for high-risk provinces versus the remainder with an attributable fraction in exposed populations of 16.52% (95% confidence interval = 12.22-20.62). Data show a robust positive statistical association between cannabis consumption as both a qualitative and quantitative variable and NTDs on a background of declining NTD incidence. In the context of multiple mechanistic pathways these strong statistical findings implicate causal mechanisms.