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Full-Text Articles in Medicine and Health Sciences
Searching For Binding Partners For The Novel Phkg1 Variant, Phkγ 181, Kishore Polireddy
Searching For Binding Partners For The Novel Phkg1 Variant, Phkγ 181, Kishore Polireddy
Student Research Conference Select Presentations
Phopshorylase kinase (PhK) is a hexadecameric holoenzyme made up of four different subunits in the arrangement (αβγδ)4 and has total molecular mass of 1.3MDa. Alpha and β are regulatory subunits, γ is catalytic, and δ is an intrinsic molecule of calmodulin. PhK is a serine threonine kinase with glycogenolytic regulatory functions. Our lab has recently discovered that the γ subunit can be alternatively processed to produce a truncated form of 181 residues (γ-181). This variant of γ contains a phosphorylation site for PK-C, and its activity is influenced by this phosphorylation. We are using a LexA based yeast two hybrid …
Photochemical Studies Of Nutraceuticals In The Presence Of Cyclodextrins, Zlata Tofzikovskaya, Christine O'Connor, Mary Mcnamara
Photochemical Studies Of Nutraceuticals In The Presence Of Cyclodextrins, Zlata Tofzikovskaya, Christine O'Connor, Mary Mcnamara
Conference Papers
The photostability studies of Folic acid and Menadione Sodium Bisulfite, also known as vitamin K3, were carried out in their aqueous solutions at room temperature. Solutions of Folic acid ( 4.8 x 10-5 M) and Menadione Sodium Bisulfite (4.0 x 10-4 M) were exposed to ultraviolet radiation at a wavelength of 365 nm. During exposure absorbance of both solutions was measured using a Perkin Elmer Lamda 900 UV/VIS/NIR Spectrometer. During the stability tests it was noted that addition of β Cyclodextrin (1:1 ratio) to aqueous solutions containing the vitamin slowed down the photodegradation process. The unique shape of Cyclodextrins allows …