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Articles 1 - 14 of 14
Full-Text Articles in Medicine and Health Sciences
The Association Of Calcium Intake And Other Risk Factors With Cardiovascular Disease Among Obese Adults In Usa, Yang Chen, Sheryl Strasser, Katie Callahan, David Blackley, Yan Cao, Liang Wang, Shimin Zheng
The Association Of Calcium Intake And Other Risk Factors With Cardiovascular Disease Among Obese Adults In Usa, Yang Chen, Sheryl Strasser, Katie Callahan, David Blackley, Yan Cao, Liang Wang, Shimin Zheng
Shimin Zheng
In this study, we used a cross-sectional study design to examine the relationship between the calcium intake and risk factors for CVD among obese adults by using continuous waves of National Health and Nutrition Examination Survey (NHANES) data 1999-2010. The association between calcium intake and risk factors of CVD (hypertension, total cholesterol, HDL, glycohemoglobin), CRP, albuminuria) is assessed among obese adults in USA. The incidence of Cardiovascular Disease (CVD) is high among obese people. The potential effects of inadequate calcium intake on CVD are receiving increased epidemiologic attention. Understanding the association between risk factors for CVD and calcium intake among …
Zona Pellucida-Induced Acrosome Reaction In Human Sperm: Dependency On Activation Of Pertussis Toxin-Sensitive G(I) Protein And Extracellular Calcium, And Priming Effect Of Progesterone And Follicular Fluid., Alessandro Schuffner, Hadley Bastiaan, E. Duran, Zin-Yong Lin, Mahmood Morshedi, Daniel Franken, Sergio Oehninger
Zona Pellucida-Induced Acrosome Reaction In Human Sperm: Dependency On Activation Of Pertussis Toxin-Sensitive G(I) Protein And Extracellular Calcium, And Priming Effect Of Progesterone And Follicular Fluid., Alessandro Schuffner, Hadley Bastiaan, E. Duran, Zin-Yong Lin, Mahmood Morshedi, Daniel Franken, Sergio Oehninger
Eyup Hakan Duran
In these studies, we aimed to characterize the effects of the physiological, homologous agonists of the acrosome reaction, i.e. the zona pellucida (ZP) and progesterone/follicular fluid, on human sperm. The specific aims of our studies were: (i) to examine the dependency of the solubilized ZP-induced acrosome reaction on G(i) protein activation and presence of extracellular calcium; and (ii) to determine whether progesterone/follicular fluid exert a priming or synergist effect on the solubilized ZP-induced acrosome reaction. Highly motile sperm from fertile donors were exposed to the agonists in a microassay and the acrosomal status of live sperm was determined by indirect …
Partial Replacement Of Nacl Can Be Achieved With Potassium, Magnesium And Calcium Salts In Brown Bread, Karen Charlton, Naomi Levitt, Krisela Steyn, Elizabeth Macgregor, Nonnie Vorster
Partial Replacement Of Nacl Can Be Achieved With Potassium, Magnesium And Calcium Salts In Brown Bread, Karen Charlton, Naomi Levitt, Krisela Steyn, Elizabeth Macgregor, Nonnie Vorster
Karen E. Charlton
Objectives: To develop a reduced sodium bread in which salt (NaCl) is partially replaced with K, Mg, and Ca salts. Methods: Experimental bread was compared against standard brown bread, after a drop test (to assess whether bread quality deteriorates with abuse) and after usual baking practices for baking properties (volume, crust colour, crumb colour and cell structure), sensory properties and nutritional composition. Plant production feasibility was evaluated in an industrial plant. Breads produced there were subjected to sensory evaluation using triangulation tests in a panel of 122 consumers. Twenty-four samples of both standard and experimental bread were laboratory-analysed for Na, …
Calcium And Vitamin D For The Reproductive Female, Rachel A. Maassen
Calcium And Vitamin D For The Reproductive Female, Rachel A. Maassen
Rachel A Maassen
The importance of calcium as well as its interdependence upon vitamin D is well established. Vitamin D acts via the vitamin D receptor, which is found in 37 different human tissues. Because of its rather ubiquitous localization, vitamin D is the topic of a great deal of associative research. However, caution must be exercised in interpreting these initial studies until clear evidence for causality becomes available. The purpose of this article is to review some of the known vitamin D and calcium associations as well as the current guidelines for calcium and vitamin D supplementation.
Relative Safety Of Hyperinsulinaemia/Euglycaemia Therapy In The Management Of Calcium Channel Blocker Overdose: A Prospective Observational Study, S Greene, I Gawarammana, David Wood, Alison Jones, Paul Dargan
Relative Safety Of Hyperinsulinaemia/Euglycaemia Therapy In The Management Of Calcium Channel Blocker Overdose: A Prospective Observational Study, S Greene, I Gawarammana, David Wood, Alison Jones, Paul Dargan
Alison L Jones
Objective: To examine the clinical safety of hyperinsulinaemia/ euglycaemia therapy (HIET) in calcium channel blocker (CCB) poisoning. Design: A prospective observational study examining biochemical and clinical outcomes of a HIET protocol administered under local poisons centre guidance. Setting: Critical care settings. Patients: Seven patients with significant CCB toxicity [systolic blood pressure (BP) < 90 mmHg] treated with HIET. Interventions: HIET was commenced after correction of any pre-existing hypoglycaemia ([blood glucose]< 65 mg/dl) or hypokalaemia ([K+] < 3.5 mmol/l). A quantity of 50 ml of 50% intravenous dextrose was followed by a loading dose (1 unit/kg) of intravenous short-acting insulin and an insulin maintenance infusion (0.5–2.0 units/kg/h). Euglycaemia was maintained using 5–10% dextrose infusions. Potassium was maintained within low normal range (3.8–4.0 mmol/l). Measurements and results: Six patients survived. All patients received fluids, calcium, and conventional inotropes. Three patients (who all ingested diltiazem) received an insulin-loading dose; all experienced a significant sustained rise in systolic BP (> 10 mmHg) during the first hour of HIET. Systolic BP did not increase significantly in four patients who did not receive insulin loading. Single episodes of non-clinically significant biochemical hypoglycaemia and hypokalaemia were recorded in one and two patients respectively. Hypoglycaemia was not recorded in any patient administered …
Calcium Salts, Alison Jones, Robert Flanagan
Role Of E-Cadherin In The Response Of Tumor Cell Aggregates To Lymphatic, Venous And Arterial Flow: Measurement Of Cell-Cell Adhesion Strength, Stephen W. Byers, Connie L. Sommers, Becky Hoxter, Arthur M. Mercurio, Aydin Tozeren
Role Of E-Cadherin In The Response Of Tumor Cell Aggregates To Lymphatic, Venous And Arterial Flow: Measurement Of Cell-Cell Adhesion Strength, Stephen W. Byers, Connie L. Sommers, Becky Hoxter, Arthur M. Mercurio, Aydin Tozeren
Arthur M. Mercurio
Defects in the expression or function of the calcium dependent cell-cell adhesion molecule E-cadherin are common in invasive, metastatic carcinomas. In the present study the response of aggregates of breast epithelial cells and breast and colon carcinoma cells to forces imposed by laminar flow in a parallel plate flow channel was examined. Although E-cadherin negative tumor cells formed cell aggregates in the presence of calcium, these were significantly more likely than E-cadherin positive cell aggregates to disaggregate in response to low shear forces, such as those found in a lymphatic vessel or venule (< 3.5 dyn/cm2). E-cadherin positive normal breast epithelial cells and E-cadherin positive breast tumor cell aggregates could not be disaggregated when exposed to shear forces in excess of those found in arteries (> 100 dyn/cm2). E-cadherin negative cancer cells …
Regulation Of Cellular Interactions With Laminin By Integrin Cytoplasmic Domains: The A And B Structural Variants Of The Alpha 6 Beta 1 Integrin Differentially Modulate The Adhesive Strength, Morphology, And Migration Of Macrophages, Leslie M. Shaw, Arthur M. Mercurio
Regulation Of Cellular Interactions With Laminin By Integrin Cytoplasmic Domains: The A And B Structural Variants Of The Alpha 6 Beta 1 Integrin Differentially Modulate The Adhesive Strength, Morphology, And Migration Of Macrophages, Leslie M. Shaw, Arthur M. Mercurio
Arthur M. Mercurio
Several integrin alpha subunits have structural variants that are identical in their extracellular and transmembrane domains but that differ in their cytoplasmic domains. The functional significance of these variants, however, is unknown. In the present study, we examined the possibility that the A and B variants of the alpha 6 beta 1 integrin laminin receptor differ in function. For this purpose, we expressed the alpha 6A and alpha 6B cDNAs, as well as a truncated alpha 6 cDNA (alpha 6-delta CYT) in which the cytoplasmic domain sequence was deleted after the GFFKR pentapeptide, in P388D1 cells, an alpha 6 deficient …
Membrane Cytoskeleton: Pip(2) Pulls The Strings, Thomas Nebl, Sang Oh, Elizabeth Luna
Membrane Cytoskeleton: Pip(2) Pulls The Strings, Thomas Nebl, Sang Oh, Elizabeth Luna
Elizabeth J. Luna
A recent application of optical tweezers has shown that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) levels control adhesion of the membrane bilayer to the underlying cytoskeleton, by regulated direct binding of PIP(2) to cytoskeletal proteins and/or indirect effects on cytoskeleton structure.
Antioxidant Effect Of Zinc And Zinc-Metallothionein In The Acute Cytotoxicity Of Hydrogen Peroxide In Ehrlich Ascites Tumour Cells, Zacharias Suntres, Ed Lui
Antioxidant Effect Of Zinc And Zinc-Metallothionein In The Acute Cytotoxicity Of Hydrogen Peroxide In Ehrlich Ascites Tumour Cells, Zacharias Suntres, Ed Lui
Edmund M. K. Lui
This study was concerned with the role of zinc (Zn) and zinc-metallothionein (Zn-MT) in oxidative stress. Hydrogen peroxide-induced oxidative injury was examined in Ehrlich ascites tumour cells isolated from control host mice, mice pretreated with 10 mg/kg ZnSO4 (i.p.) to increase cellular Zn/Zn-MT levels, and mice exposed to Zn-deficient diet to reduce the cellular Zn/Zn-MT levels. The results of the present study showed that Ehrlich cells with seven-fold differences in Zn-MT concentrations could be obtained by manipulating the Zn status of host mice and that high Zn and Zn-MT levels can make Ehrlich cells more resistant to H2O2-induced oxidative injury …
Prooxidative Effect Of Copper-Metallothionein In The Acute Cytotoxicity Of Hydrogen Peroxide In Ehrlich Ascites Tumour Cells, Zacharias Suntres, Ed Lui
Prooxidative Effect Of Copper-Metallothionein In The Acute Cytotoxicity Of Hydrogen Peroxide In Ehrlich Ascites Tumour Cells, Zacharias Suntres, Ed Lui
Edmund M. K. Lui
This study was concerned with the role of copper (Cu) and Cu-metallothionein (Cu-MT) in oxidative stress. Hydrogen peroxide (H(2)O(2))-induced oxidative injury was examined in Ehrlich ascites tumour cells isolated from host mice pretreated with 0, 1 or 2mg of CuSO(4) (ip) 24h earlier. Control Ehrlich cells contained low levels of Cu and Cu treatment produced dose-related increases in cellular Cu and Cu-MT levels and corresponding increases in sensitivity to oxidative toxicity of H(2)O(2) (LC(50), cell blebbing, lipid peroxidation, GSH depletion, and increase in intracellular free [Ca(2+)](i)). Hydrogen peroxide treatment also resulted in the oxidation of MT thiolates, reduction in the …
Educational Materials Review: Calcium: Are You Getting Enough?, Abigail Field, Christina Pruemer, Melanie Burns
Educational Materials Review: Calcium: Are You Getting Enough?, Abigail Field, Christina Pruemer, Melanie Burns
Melanie Burns
No abstract provided.
Low Calcium Diet And 1,25-Dihydroxyvitamin D3 Infusion Modulate Immune Responses During Mycobacterium Paratuberculosis Infection In Geige Mice, Judith R. Stabel, Jesse P. Goff, Diana L. Whipple, Mark R. Ackermann, Timothy A. Reinhardt
Low Calcium Diet And 1,25-Dihydroxyvitamin D3 Infusion Modulate Immune Responses During Mycobacterium Paratuberculosis Infection In Geige Mice, Judith R. Stabel, Jesse P. Goff, Diana L. Whipple, Mark R. Ackermann, Timothy A. Reinhardt
Mark R. Ackermann
A 12-month study was conducted to evaluate the effects of feeding a low calcium (Ca) diet or 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) infusion on the persistence of Mycobacterium paratuberculosis infection using a mouse model. Male beige mice 6–8 weeks of age were assigned to one of the following treatments: (1) non-infected, (2) infected, (3) non-infected/1,25(OH)2D3, (4) infected/1,25(OH)2D3, and (5) infected/low Ca (0.15%) diet. Infected mice were inoculated intravenously with live M. paratuberculosis. At 1, 6 and 12 months postinfection, mice in Treatments 3 and 4 were implanted subcutaneously with mini-osmotic pumps to deliver 1,25(OH)2D3. Infusion with 1,25(OH)2D3 exacerbated M. paratuberculosis infection in …
Vitamin D And Parotid Gland Function In The Rat, C. Peterfy, A. Tenenhouse, E. Yu
Vitamin D And Parotid Gland Function In The Rat, C. Peterfy, A. Tenenhouse, E. Yu
Edward Yu
1. We previously reported that parotid gland secretion is decreased in rats deprived of vitamin D (Glijer, Peterfy & Tenenhouse, 1985). In the present study we examine whether this effect is a direct result of the absence of vitamin D or due to the secondary systemic effects of vitamin D deficiency. 2. Offspring of rats maintained on a calcium-supplemented (1.2%), vitamin-D-deficient diet were weaned onto the same diet and examined after 8 weeks. Using this method it was possible to maintain serum calcium and parathyroid hormone concentrations within normal limits. Serum 25-hydroxyvitamin D (25(OH)D3) was not detectable, but 1,25-dihydroxyvitamin D …