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Full-Text Articles in Medicine and Health Sciences
Measuring Plasma Salicylate Concentrations In All Patients With Drug Overdose Or Altered Consciousness: Is It Necessary?, David Wood, Paul Dargan, Alison Jones
Measuring Plasma Salicylate Concentrations In All Patients With Drug Overdose Or Altered Consciousness: Is It Necessary?, David Wood, Paul Dargan, Alison Jones
Alison L Jones
Background: Salicylate self poisoning is potentially fatal. Plasma salicylate concentrations can be used to guide management when taken in the context of clinical features of toxicity and acid base status. Previous studies in the USA and Hong Kong have shown that routine measurement of plasma salicylate concentrations in all overdose patients is inappropriate, but there have been no previous studies in the UK. Methods: A retrospective case note study from 1 February 2001 to 31 January 2002 was undertaken at the emergency department of St. Thomas’ Hospital, London. Records were reviewed and information on demographic data, history, details of salicylate …
Plasma Salicylate Concentrations Following Overdose; Are They Worth It ?, David Muir Wood, Alison Jones, Paul Dargan
Plasma Salicylate Concentrations Following Overdose; Are They Worth It ?, David Muir Wood, Alison Jones, Paul Dargan
Alison L Jones
Treatment following salicylate ingestion is determined by clinical evidence of toxicity. Previous studies have shown that routine measurement of plasma salicylate concentrations in all overdose patients is unnecessary except in those with clinical features suggestive of salicylate poisoning or in those who are unable to give an accurate history [1]. This retrospective study evaluates whether plasma salicylate concentrations are appropriately measured. A retrospective study of all plasma salicylate concentrations measured in St Thomas’ Hospital Accident and Emergency department from 1 February 2001 to 31 January 2002 was conducted. Admission record cards were surveyed for history of salicylate ingestion, clinical features …
Analysis Of Serial Serum Alpha-Fetoprotein Concentrations In Patients With Cirrhosis, Alison Jones, J Plevris, C Shearing, I.A.D Bouchier, P Hayes
Analysis Of Serial Serum Alpha-Fetoprotein Concentrations In Patients With Cirrhosis, Alison Jones, J Plevris, C Shearing, I.A.D Bouchier, P Hayes
Alison L Jones
No abstract provided.
Propafenone Poisoning: A Case Report With Plasma Propafenone Concentrations, Hanna Ovaska, Andrew Ludman, Edgar Spencer, David Wood, Alison Jones, Paul Dargan
Propafenone Poisoning: A Case Report With Plasma Propafenone Concentrations, Hanna Ovaska, Andrew Ludman, Edgar Spencer, David Wood, Alison Jones, Paul Dargan
Alison L Jones
Propafenone is an anti-arrhythmic drug used in the management of supraventricular and ventricular arrhythmias. It is metabolised through cytochrome P450 2D6 pathways; the major metabolites possess antiarrhythmic activity. The cytochrome P450 CYP2D6 is coded by more than 70 alleles resulting in great genetic polymorphism of CYP2D6 isoenzymes, and up to 7% of Caucasian population are poor metabolisers. This case report describes a patient with severe overdose of propafenone who presented with coma, seizures and cardiotoxicity. The patient was managed with intravenous glucagon, hypertonic sodium bicarbonate, hypertonic saline and inotropic support. The propafenone and its 5-hydroxypropafenone (5-OHP) metabolite were measured by …
Soluble Adhesion Molecules And Interleukin-2 Receptor Concentrations In Patients With Autoimmune Chronic Hepatitis, K Simpson, Alison Jones, A. Howie Forbes, P Hayes
Soluble Adhesion Molecules And Interleukin-2 Receptor Concentrations In Patients With Autoimmune Chronic Hepatitis, K Simpson, Alison Jones, A. Howie Forbes, P Hayes
Alison L Jones
To test the hypothesis that elevated serum levels of intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), (s)E-selectin, (s)P-selectin and soluble interleukin-2 receptor (sIL-2R) occur in patients with biochemically inactive autoimmune hepatitis (AICH) compared with controls. Such a finding would suggest continued immune activation, which in the long-term would contribute to the development of cirrhosis in such patients.