Medicine and Health Sciences | Open Access Articles

Use Of Veterinary Records To Teach Laboratory Thinking Skills In Biology, Christopher Woolverton

Christopher J. Woolverton

No abstract provided.

Welcome To The Journal Of Evolution And Health, Aaron Blaisdell, Paul Jaminet, David C. Pendergrass

Aaron P Blaisdell

Welcome to the first issue of the Journal of Evolution and Health! The Journal of Evolution and Health is the peer-reviewed, open-access journal of the Ancestral Health Society, a community of scientists, healthcare professionals, and laypersons who collaborate to understand health challenges from an evolutionary perspective.

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Iqcb1 And Pde6b Mutations Cause Similar Early Onset Retinal Degenerations In Two Closely Related Terrier Dog Breeds, Orly Goldstein, Jason G. Mezey, Peter A. Schweitzer, A. Boyko, Chuan Gao, Carlos D. Bustamante, Julie Ann Jordan, Gustavo D. Aguirre, Gregory M. Acland

Gustavo D. Aguirre, VMD, PhD

Purpose.: To identify the causative mutations in two early-onset canine retinal degenerations, crd1 and crd2, segregating in the American Staffordshire terrier and the Pit Bull Terrier breeds, respectively.

Methods.: Retinal morphology of crd1- and crd2-affected dogs was evaluated by light microscopy. DNA was extracted from affected and related unaffected controls. Association analysis was undertaken using the Illumina Canine SNP array and PLINK (crd1 study), or the Affymetrix Version 2 Canine array, the “MAGIC” genotype algorithm, and Fisher's Exact test for association (crd2 study). Positional candidate genes were evaluated for each disease.

Results.: Structural photoreceptor abnormalities were observed in crd1 …

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Anesthetizing The Public Conscience: Lethal Injection And Animal Euthanasia, Ty Alper

Ty Alper

No abstract provided.

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Transient Photoreceptor Deconstruction By Cntf Enhances Raav-Mediated Cone Functional Rescue In Late Stage Cngb3-Achromatopsia, Andras Komaromy, Jessica S. Rowlan, Amanda T. Parton Corr, Shelby L. Reinstein, Sanford L. Boye, Ann E. Cooper, Amaliris Gonzalez, Britt Levy, Rong Wen, William W. Hauswirth, William A. Beltran, Gustavo D. Aguirre

Gustavo D. Aguirre, VMD, PhD

Achromatopsia is a genetic disorder of cones, and one of the most common forms is a channelopathy caused by mutations in the β-subunit, CNGB3, of the cone cyclic nucleotide-gated (CNG) channel. Recombinant adeno-associated virus of serotype 5 (rAAV5)-mediated gene transfer of human CNGB3 cDNA to mutant dog cones results in functional and structural rescue in dogs <0.5 years of age, but treatment is minimally effective in dogs >1 year. We now test a new therapeutic concept by combining gene therapy with the administration of ciliary neurotrophic factor (CNTF). Intravitreal CNTF causes transient dedifferentiation of photoreceptors, a process called deconstruction, whereby …

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Full-Text Articles in Medicine and Health Sciences

Use Of Veterinary Records To Teach Laboratory Thinking Skills In Biology, Christopher Woolverton

Christopher J. Woolverton

Welcome To The Journal Of Evolution And Health, Aaron Blaisdell, Paul Jaminet, David C. Pendergrass

Aaron P Blaisdell

Iqcb1 And Pde6b Mutations Cause Similar Early Onset Retinal Degenerations In Two Closely Related Terrier Dog Breeds, Orly Goldstein, Jason G. Mezey, Peter A. Schweitzer, A. Boyko, Chuan Gao, Carlos D. Bustamante, Julie Ann Jordan, Gustavo D. Aguirre, Gregory M. Acland

Gustavo D. Aguirre, VMD, PhD

Anesthetizing The Public Conscience: Lethal Injection And Animal Euthanasia, Ty Alper

Ty Alper

Gustavo D. Aguirre, VMD, PhD