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Low Calcium Diet And 1,25-Dihydroxyvitamin D3 Infusion Modulate Immune Responses During Mycobacterium Paratuberculosis Infection In Geige Mice, Judith R. Stabel, Jesse P. Goff, Diana L. Whipple, Mark R. Ackermann, Timothy A. Reinhardt
Low Calcium Diet And 1,25-Dihydroxyvitamin D3 Infusion Modulate Immune Responses During Mycobacterium Paratuberculosis Infection In Geige Mice, Judith R. Stabel, Jesse P. Goff, Diana L. Whipple, Mark R. Ackermann, Timothy A. Reinhardt
Mark R. Ackermann
A 12-month study was conducted to evaluate the effects of feeding a low calcium (Ca) diet or 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) infusion on the persistence of Mycobacterium paratuberculosis infection using a mouse model. Male beige mice 6–8 weeks of age were assigned to one of the following treatments: (1) non-infected, (2) infected, (3) non-infected/1,25(OH)2D3, (4) infected/1,25(OH)2D3, and (5) infected/low Ca (0.15%) diet. Infected mice were inoculated intravenously with live M. paratuberculosis. At 1, 6 and 12 months postinfection, mice in Treatments 3 and 4 were implanted subcutaneously with mini-osmotic pumps to deliver 1,25(OH)2D3. Infusion with 1,25(OH)2D3 exacerbated M. paratuberculosis infection in …