Medicine and Health Sciences Commons^™

Rehabilitation Is Associated With Lower Mortality In Patients With Dengue Fever In Intensive Care Units: A Retrospective Study, Hsin-Han Cheng, Chin-Ming Chen, Willy Chou

Rehabilitation Practice and Science

Objective: The study aimed to examine the effect of rehabilitation on mortality in patients with dengue in intensive care units (ICUs). Design: This was a retrospective cohort study. In this study, 142 patients with dengue from ICUs were enrolled from August to December, 2015. They were divided into two groups: patients with or without rehabilitation. The relationship between rehabilitative therapy and the risk of dengue-related mortality was assessed using a multivariate Cox regression model after adjustment for related variables. Results: Of the 142 patients, 70 (49.3%) were men, and the mean age was 69.97 ± 15.93 years. The average length …

Profile Of Patients Neutropenia Fever Unrelated To Chemotherapy In Dr. Cipto Mangunkusumo General Hospital, Gantira Danasasmita, Lie Khie Chen, Robert Sinto, Pringgodigdo Nugroho

Jurnal Penyakit Dalam Indonesia

Introduction. The condition of neutropenia increases the risk of infection. The causes of neutropenia are widely discussed as side effects of chemotherapy, but patients with neutropenia who are not due to side effects of chemotherapy are increasing in number. This study aims to provide an overview of the characteristics of neutropenic fever population unrelated to chemotherapy. Method. The study was conducted retrospectively on the medical records of neutropenic fever patients who were not chemotherapy-related in the National Hospital Dr. Cipto Mangunkusumo in January 2018-November 2019. Variables studied included demographic, clinical characteristics, classification of multinational association of supportive care in cancer …

The Effect Of Hydroxychloroquine On In-Hospital Mortality In Covid-19, Samar Aboulenain, Nakeya Dewaswala, Fergie Ramos, Pedro Torres, Ahmed Abdallah, Mohamed Abdul Qader, Baher Al-Abbasi, Charles R. Bornmann, Karolina N. Dziadkowiec, Kai Chen, Jesus E. Pino, Robert Chait, Kleper De Almeida

HCA Healthcare Journal of Medicine

Background: Hydroxychloroquine (HCQ) is an antimalarial medication that has been tested against various viral illnesses. The available evidence regarding the role of HCQ in the coronavirus disease 2019 (COVID-19) remains controversial.

Methods: This is a comparative retrospective cohort study that aims to evaluate the efficacy and safety of HCQ in hospitalized patients with COVID-19. The primary outcome was all-cause in-hospital mortality. Secondary outcomes included ICU admission rate, mechanical ventilation, prolonged length of stay (LOS), QTc prolongation and cardiac arrest.

Results: A cohort of 175 hospitalized patients with COVID-19 were included with a median (interquartile range [IQR]) age of 66 [48–79] …

Age, Comorbidities, And Mortality Correlation In Covid-19 Patients: A Review, Vidyulata Salunkhe, Amr Aboelnasr, Parul Pahal, Nida Qadir, Simra Kiran, Balaji Sekaran, Omar Fahmy, Farah Daas, Syed Shah

The University of Louisville Journal of Respiratory Infections

Background: The risk of death due to COVID-19 among hospitalized patients is known to be higher in older adults and those with underlying health conditions. Understanding the proportion of patients who are at increased risk of death due to COVID-19 and how this varies between age groups will inform the healthcare community as to how to evaluate the risk of COVID-19 and better design healthcare and economic policies.

Methods: We conducted a literature search for studies published between December 2019 and May 16, 2020 in PubMed, Embase, and Cochrane (CENTRAL). Descriptive statistics were performed.

Results: We reviewed 14 studies, of …

Assessing The Impact Of A Community-Based Pro-Active Monitoring Program Addressing The Need For Care Of Community-Dwelling Citizens Aged More Than 80: Protocol For A Prospective Pragmatic Trial And Results Of The Baseline Assessment, Elisa Terracciano

Translational Medicine @ UniSa

The aim of this paper is to describe the protocol of a study assessing the impact of a Communitybased pro-Active Monitoring Program, by measuring the effect in counteracting the adverse outcomes related to frailty. Methods: a prospective pragmatic trial will be carried out to describe the impact of an intervention on people aged>80, adjusted for relevant parameters: demographic variables, comorbidities, disability and bio-psycho-social frailty. They have been assessed with the Functional Geriatric Evaluation questionnaire that is a validated tool. Mortality, Acute Hospital Admission rates, Emergency Room Visit rates and Institutionalization rates are the main outcomes to be evaluated annually, …

Prediction Model Of 30-Day Mortality In Elderly Patients Admitted To Geriatric Acute Ward Using Comprehensive Geriatric Assessment Domain, Noto Dwimartutie, Slti Setiati, Edy Rizal Wahyudi, Kuntjoro Harimurti

Jurnal Penyakit Dalam Indonesia

No abstract provided.

The Prognostic Impact Of Pulse Pressure In Acute Heart Failure: Insights From The Hearts Registry, Alwaleed Aljohar, Khalid Alhabib, Hussam Alfaleh, Ahmad Hersi, Waleed Al Habeeb, Anhar Ullah, Abdelfatah Elasfar, Ali Almasood, Abdullah Ghabashi, Layth Mimish, Saleh Alghamdi Alghamdi, Ahmed Abuosa, Asif Malik, Gamal Abdin Hussein, Mushabab Al Murayeh, Tarek Kashour

Journal of the Saudi Heart Association

Background: Low pulse pressure predicts long-term mortality in chronic heart failure, but its prognostic value in acute heart failure is less understood. The present study was designed to examine the prognostic value of pulse pressure in acute heart failure.

Methods: Pulse pressure was tested for its impact on short- and long-term mortality in all patients admitted with acute heart failure from October 2009 to December 2010 in eighteen tertiary centers in Saudi Arabia (n ¼ 2609). All comparisons were based on the median value (50 mmHg). Heart failure with reduced ejection fraction was defined as less than 40%.

Results: Low …

Outcomes Of Patients Hospitalized With Community-Acquired Pneumonia With Liver Disease Or Cirrhosis., Bibodh Jung Karki, Sravan K. Ponnekanti, Vidyulata Salunkhe, Nishita Tripathi, Mahder A. Tella, Stephen P. Furmanek, Forest W. Arnold

The University of Louisville Journal of Respiratory Infections

Introduction: Liver disease and cirrhosis are common causes of mortality worldwide. Community-acquired pneumonia is recognized as a significant cause of morbidity and mortality in this population of adults. There is a lack of data regarding outcomes or prognosis in patients with liver dysfunction who develop CAP. The objective of this study was to evaluate the clinical characteristics, incidence, and outcomes of hospitalized patients with CAP and liver disease.

Methods: This was a secondary analysis of the University of Louisville Pneumonia Study, which was a prospective population-based cohort study of adults hospitalized with community-acquired pneumonia. All patients were divided into three …

Systemic Immune-Inflammation Index Predicts Mortality In Infective Endocarditis, Hicaz Z. Agus, Serkan Kahraman, Cagdas Arslan, Ceren Yildirim, Mehmet Erturk, Ali K. Kalkan, Mustafa Yildiz

Journal of the Saudi Heart Association

Objectives: The aim of our study was to evaluate the usefulness of systemic immune-inflammation index (SII) at admission in predicting in-hospital mortality in patients with infective endocarditis. Methods: 133 definite IE patients (≥18 years) according to modified Duke criteria, treated in our tertiary care hospital between December 2009 and May 2019, were retrospectively analysed. Symptoms, comorbidities, predisposing valvular diseases, prosthetic valve, device, history of injectable drug use, blood culture results, echocardiography findings, and complications were collected. We calculated the SII as follows: SII¼platelet count£neutrophil count/lymphocyte count at admission. Results: The median age of the patients was 56 (40e66) years. Prosthetic …

Diabetes Mellitus And Necrotizing Fasciitis – A Deadly Combination; Case Report, Alexandra Toma, Laura Mazilu, Andra Iulia Suceveanu, Florentina Gherghiceanu, Camelia Sandu, Cristina Bica, Liliana Florina Andronache, Ioana Paunica, Lavinia Alexandra Moroianu

Journal of Mind and Medical Sciences

Necrotizing fasciitis is a rapidly destructive affliction of soft tissues, with a mortality rate that may reach 73% of the cases. It is characterized by a progressive inflammation and extended necrosis of the subcutaneous tissue and the fascia. Necrotizing fasciitis was first described in 1848, and later in 1920 Meleney identified 20 patients in China in which the infection was presumably triggered by hemolytic streptococcus, linking pathological bacteria to the condition. In 1952, Wilson coined the term necrotizing fasciitis although without successfully identifying the specific pathological bacteria involved. In most cases, both risk and aggravating factors are present, the main …

Prevalence Of Glucose Level Abnormalities In Neonatal Sepsis And Its Association With Mortality, Abd El Hameed R A. Issa, Dalia M. Ellahony, Muhammad S. El-Mekkawy

Menoufia Medical Journal

Objective To determine the prevalence of plasma glucose abnormalities among infants with neonatal sepsis and their association with mortality and morbidity. Background Plasma glucose abnormalities were previously noted in neonatal sepsis, but data in full-term neonates is limited and the association with mortality and morbidity is not established. Patients and methods This was a prospective observational study including 114 full-term neonates with culture-proven and probable sepsis. Plasma glucose level was measured within 2 h of neonatal intensive care unit admission and the patients were monitored till discharge or mortality. The patients were divided into three groups according to their plasma …

Association Of Drowning Mortality With Preventive Interventions: A Quarter Of A Million Deaths Evaluation In Brazil, David Szpilman, Danielli B. Mello, Ana Catarina Queiroga, Rogerio Ferreira Emygdio Rfe

International Journal of Aquatic Research and Education

In 2015, drowning in Brazil was responsible for 6,043 deaths and was the second leading cause of death in children. Although several prevention strategies have been promoted to reduce drowning, most are still based on low levels of evidence. This study evaluated the effectiveness of prevention and water safety interventions in reducing drowning mortality. Data obtained from the National Mortality System for 36 years were split in two time periods to allow the comparison of drowning mortality numbers before and after implementation of SOBRASA’s drowning prevention and water safety programs and to check for any positive effects attributable to such …

Risk Indices That Predict In-Hospital Mortality Of Elderly Patients, Di̇lek Dülger, Özgür Albuz

Turkish Journal of Medical Sciences

Background/aim: Mortality in the elderly population tends to be higher than in all other age groups; the risk factors that predict mortality among those in this age cohort are not fully understood. This large-scale clinical study aimed to identify effective risk factors that predict mortality in the elderly population with a particular focus on age and hospitalization status. Material and methods: We retrospectively analyzed outcomes from patients with clinical follow-up between July 2015 and January 2020 at 29 Mayıs State Hospital, Ankara, Turkey. Patient records with missing or ambiguous data were excluded. Age, sex, length of hospital stay, comorbidities, consultation …

Embryonic Mortality In Sheep: A Review, Pavitra Chundekkad, Barbara Blaszczyk, Tomasz Stankiewicz

Turkish Journal of Veterinary & Animal Sciences

Despite extensive research on the reproductive health of domestic animals, embryonic mortality continues to be a problem that brings about significant losses for both commercial breeding and scientific research. This review paper discusses the genetic and environmental factors that affect embryo mortality rates in sheep along with the different techniques developed to overcome this issue. Additionally, one of the objectives of this study is to emphasize the importance of the use of time-lapse cinematography and color Doppler ultrasonography as quick and reliable methods for early detection of pregnancy and embryonic death.

Assessment Of The Molluscicidal Activity Of Wormwood (Artemisia Dubia, Wallich) Leaves Ethanolic Extract On Oncomelania Hupensis Quadrasi, Möllendorff, Claudine C. Terciño, Carl Leonard M. Pradera, Melvin A. Bagot

Turkish Journal of Veterinary & Animal Sciences

This study assessed the in vitro molluscicidal activity of Artemisia dubia (wormwood) leaf ethanolic extract against adult and juvenile Oncomelania hupensis quadrasi and profiled its qualitative phytochemical content. The plants and snails were collected locally. There were 8 concentrations used for adult and juvenile snails: distilled water and 1% ethanol as negative controls; niclosamide (2 mg/L) as a positive control; and different concentrations of wormwood ethanolic extracts for adult snails including 3.98% (T1), 4.46% (T2), 5% (T3), 5.61% (T4), and 6.30% (T5) and for juvenile snails including 7.94% (T1), 8.91% (T2), 10% (T3), 11.22% (T4), and 12.59% (T5). Each treatment …

Statistical Analysis Of The Relationship Between Mortality And Nosocomial Factors Inpatients With Septicemia And The Importance Of Pseudomonas Aeruginosa, Di̇lek Dülger

Turkish Journal of Veterinary & Animal Sciences

The ongoing evolution of sepsis as a condition constitutes a global health concern and necessitates continuous monitoring and investigation of incidence rates, mortality factors, and disease patterns. This study sought to elucidate the frequency of bacterial cultures in patients with septicemia at our hospital and identify the factors influencing mortality. Zoonotic risk factors with reference to the literature were also taken into account.Independent variables of all patients diagnosed with sepsis were retrospectively screened to reveal factors affecting mortality. Incomplete or unclear data were not included. Continuous variables are represented as means and standard deviations, whereas binary variables are represented as …

An Epidemiologic Study Of Physician-Diagnosed Chronic Obstructive Pulmonary Disease In The Turkish Population: Copdturkey-1, Tarkan Özdemi̇r, Ni̇lgün Yilmaz Demi̇rci̇, Hati̇ce Kiliç, Orhan Koç, Akin Kaya, Can Öztürk

Turkish Journal of Medical Sciences

Background/aim: Chronic obstructive pulmonary disease (COPD) is a common disease characterized by persistent airflow limitation and respiratory symptoms. It is a leading cause of morbidity and mortality all over the world. Our data on COPD in Turkey are limited. This study was intended to examine the epidemiologic characteristics of COPD in the Turkish population, between 2012 and 2016. Materials and methods: This population-based, descriptive, surveillance study examined physician-diagnosed COPD prevalence, incidence, and mortality in Turkey.The database of the Social Security System of Turkey was scanned and ICD-10 J44.0-J44.9 codes for diagnostic and/or therapeutic purposes were evaluated retrospectively. Results: In 2016, …

Long-Term Clinical Outcomes Of Peritoneal Dialysis Patients: 9-Year Experience Of A Singlecentre In Turkey, Ni̇han Tekkarişmaz, Di̇lek Torun

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to evaluate the clinical outcomes and identify the predictors of mortality in peritoneal dialysis patients. Materials and methods: Medical records of all incident peritoneal dialysis (PD) patients followed up between January 2011 and May 2019 were reviewed retrospectively. All patients were followed up until death, renal transplantation, transfer to haemodialysis or the end of the study. Results: A total of 242 patients were included in the study. The incidence of peritonitis was 0.18 (ranging from 0 to 14.9) episodes per patient year. Death occurred in 28% (n: 68) of cases. Age, diabetes mellitus, …

Value Of Prognostic Scores In Antineutrophil Cytoplasmic Antibody (Anca) Associated Vasculitis Patients In Intensive Care Unit: A Multicenter Retrospective Cohort Study From Turkey, Uğur Özdemi̇r, Nazmi̇ye Ebru Ortaç Ersoy, Recep Ci̇van Yüksel, Erhan Kaya, Şahender Gülbi̇n Aygencel Bikmaz, Melda Türkoğlu, Arzu Topeli̇ İski̇t, Muhammet Güven, Murat Sungur, Neri̇man Defne Altintaş

Turkish Journal of Medical Sciences

Background/aim: There is a need for a scoring system for predicting ICU prognosis of patients with ANCA-associated vasculitis (AAV), but there are limited data on it in the literature. Therefore, we aimed to determine the scores that can estimate the prognosis of patients with AAV during intensive care follow up.Materials and methods: All adult patients admitted to the medical ICUs of 4 reference university hospitals in Turkey due to AAV activation and/or disease/treatment complications in the last 10 years were included in this study. Demographic data, treatments before ICU, the Birmingham Vasculitis Activity Score (BVAS) score at the time of …

Is 48 H A Critical Cut-Off Point For Mortality In Geriatric Hip Fractures?, Ahmet Emre Paksoy, Keri̇m Öner, Ferdi̇ Polat, Serhat Durusoy

Turkish Journal of Medical Sciences

Background/aim: In this study, our objective was to evaluate the mortality in geriatric hip fracture patients who were operated within 48 h after admission or after the 48th h. Materials and methods: A total of 194 patients who had undergone surgery for hip fracture between 2016 and 2018 were retrospectively evaluated. Patient information was obtained from the hospital?s database using the ICD codes 81.52, 82.00?82.09, and 82.10. Radiological examination reports were collected from the patient files. Information on mortality was obtained from the Death Notification System of the Turkish Ministry of Health. First-year mortality rates of patients operated within 48 …

Covid-19 Experience Of The Major Pandemic Response Center In The Capital: Results Ofthe Pandemic's First Month In Turkey, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Bi̇rcan Kayaaslan, Adalet Aypak, Ayşe Kaya Kalem, Fatma Eser, Burcu Özdemi̇r, Eli̇f Muki̇me Saricaoğlu, Müge Ayhan, Yeşi̇m Aybar Bi̇li̇r, Işil Özkoçak Turan, Deni̇z Erdem, Nevzat Mehmet Mutlu, Turan Buzğan, Bedi̇a Di̇nç

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to evaluate the epidemiological and clinical characteristics and parameters that determined the clinical course and prognosis of the COVID-19 patients admitted to Ankara City Hospital during the first month of the pandemic in Turkey. Materials and methods: SARS-CoV-2 PCR positive patients who were hospitalized between March 10 and April 10, 2020 were included. Results: Among 222 patients, mean age was higher in severe acute respiratory illness (SARI)/critical disease group (P < 0.001). Median time from illness onset to admission and presence of comorbidity, especially coronary artery disease and chronic obstructive pulmonary disease, were significantly higher in the SARI/critical disease group (P < 0.05). Cough and fever were the most common symptoms, while anosmia and loss of taste were observed in 8.6% and 7.7% patients, respectively. The mortality rate was 5.4%. A high neutrophil/lymphocyte ratio; low lymphocyte, monocyte, and platelet count; elevated liver enzymes; low GFR; and high levels of muscle enzymes, ferritin, and IL-6 on admission were found to be associated with SARI/critical disease (P < 0.05). Bilateral ground-glass opacity and patchy infiltration were more frequently seen in the SARI/critical disease group (P < 0.001). Patients older than 65 years had an 8-fold increased risk for development of SARI/critical disease. Conclusion: This cohort study regarding COVID-19 cases in Turkey reveals that older age, presence of comorbidity, bilateral infiltration on CT, high neutrophil/lymphocyte ratio, low monocyte and platelet count, elevated liver enzymes, low GFR, high levels of muscle enzymes, and high levels of ferritin and IL-6 on admission are predictors of SARI and severe disease.

Sars-Cov-2 Epidemiology And Control, Different Scenarios For Turkey, Eskild Petersen, Ayşe Deni̇z Gökengi̇n

Turkish Journal of Medical Sciences

Background/aim: Coronavirus Infectious Disease 2019 (COVID-19) is now a pandemic spreading in most countries including Turkey. Materials and methods: The current knowledge of COVID-19 and the virus causing it, SARS-CoV-2, was reviewed. The epidemiology and control in different countries was compared and the differences discussed. Results: The population attack rates and case fatality rates vary from country to country with Lombardy in northern Italy reporting an attack rate in the general population of 0.37% compared to 0.004% in Hong Kong. The differences are caused by different testing strategies and reporting systems. Conclusion: Turkey is early in the outbreak. Different control …