Medicine and Health Sciences Commons^™

Animal Models For Human Disease – Reflections From An Animal Researcher’S Perspective, Imke Tammen

Between the Species

Neuronal ceroid lipofuscinoses (NCL) are a group of lethal inherited neurodegenerative disorders in humans and many animal species. Critical reflections on a range of ethical issues concerning NCL have been instigated by my research on sheep and cattle affected with NCL, the claim that these sheep and cattle are useful models for the disease in humans, and engagement with families and support groups. My reflections on moral status of animals and validity of animal models are outlined in this paper.

Does Lack Of Enrichment Invalidate Scientific Data Obtained From Rodents By Compromising Their Welfare?, Ann L. Baldwin Phd

Between the Species

In countries where major animal research is conducted, comprehensive laws exist to ensure that the animals’ physical needs are satisfactorily met. However, animals also require an environment that allows them to fulfill their behavioral needs; this will be the focus of the article. Two studies are described in detail, one on rats and the other on genetically modified mice, which were performed by the author to compare the effects of enriched and un-enriched cage environments on rodent physiology. Evidence is presented showing that if research rodents are housed in cages lacking structures that allow them to perform their normal behaviors, …